Disease

Xerostomia

Late-stage therapeutic developmentEmerging research

MeSHXerostomia

Publications

Clinical trials

2011

Latest publication

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial.

Research2011-01-12The Lancet. Oncology

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low

Key developments

3 clinical trials expected to report results, the earliest in Q3 2027.

Upcoming Milestones

Major developments

Upcoming trial readoutHigh impact

A Phase I/IIa, Dose Escalation Study Evaluating the Safety, Tolerability, and Preliminary Efficacy of Intraductal Administration of RXRG001 to Parotid Gland(s) in Adults With Radiation-Induced Xerostomia and Hyposalivation

Results expected Q3 20272026-06-26

Upcoming trial readoutImportant

Clinical Investigation to Measure the Changes in the Oral Environment Resulting From a 12 Weeks Exposure to an Arginine Containing Toothpaste

Results expected Q4 20272026-02-10

Clinical Milestones5View

Results expected 3

2026-06-26A Phase I/IIa, Dose Escalation Study Evaluating the Safety, Tolerability, and Preliminary Efficacy of Intraductal Administration of RXRG001 to Parotid Gland(s) in Adults With Radiation-Induced Xerostomia and HyposalivationResults expected Q3 2027
2026-06-22UW23129: A Phase I Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical XerostomiaResults expected Q4 2028
2026-02-10Clinical Investigation to Measure the Changes in the Oral Environment Resulting From a 12 Weeks Exposure to an Arginine Containing ToothpasteResults expected Q4 2027

Recently completed 2

2026-06-08A Trial of Spermidine for the Prevention of Radiation-Induced XerostomiaPrimary completion
2025-12-09A Phase I Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Xerostomia After Radiation Therapy for Head and Neck CancerPrimary completion

Activity timeline5

2026-06-26ClinicalA Phase I/IIa, Dose Escalation Study Evaluating the Safety, Tolerability, and Preliminary Efficacy of Intraductal Administration of RXRG001 to Parotid Gland(s) in Adults With Radiation-Induced Xerostomia and HyposalivationResults expected Q3 2027
2026-06-22ClinicalUW23129: A Phase I Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical XerostomiaResults expected Q4 2028
2026-06-08ClinicalA Trial of Spermidine for the Prevention of Radiation-Induced XerostomiaPrimary completion
2026-02-10ClinicalClinical Investigation to Measure the Changes in the Oral Environment Resulting From a 12 Weeks Exposure to an Arginine Containing ToothpasteResults expected Q4 2027
2025-12-09ClinicalA Phase I Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Xerostomia After Radiation Therapy for Head and Neck CancerPrimary completion

Clinical trials

17 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme

All trials

Active

Late-stage

Completed

Late-stage studies

Clinical Investigation to Measure the Changes in the Oral Environment Resulting From a 12 Weeks Exposure to an Arginine Containing Toothpaste

Phase 3 · Active, not recruiting · Tufts University

A Phase II/III Study Comparing Acupuncture-like Transcutaneous Electrical Nerve Stimulation (ALTENS) Versus Pilocarpine in Treating Early Radiation-Induced Xerostomia

Phase 2/3 · Completed · Radiation Therapy Oncology Group

The Efficacy of Thyme Honey Mouth Rinse on Polypharmacy-induced Xerostomia (A Randomized Controlled Clinical Trial With a Biochemical Assessment)

Phase 4 · Completed · Ain Shams University

Comparison of Gum® HydralTM Moisturizing Gel and Biotene® Oral Gel in Dry Mouth Sensation Reduction: a Randomized Clinical Trial

Phase 3 · Completed · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Use of Biotene Moisturizing Mouth Spray for Xerostomia Associated With Oral Oxybutynin Use

Phase 4 · Withdrawn · University of Southern California

Quality of Life in a Portuguese Population With Primary Sjögren Syndrome

Phase 4 · Completed · Grupo de Investigação em Bioquímica e Biologia Oral

Recruiting

Phase 1/2 · Recruiting · RiboX Therapeutics Ltd.

A Trial of Spermidine for the Prevention of Radiation-Induced Xerostomia

Phase 1/2 · Recruiting · West China Hospital

UW23129: A Phase I Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia

Phase 1 · Recruiting · University of Wisconsin, Madison

A Phase I Study of d-Limonene With Concurrent Radiation and Platinum Based Chemotherapy for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)

Phase 1 · Recruiting · Stanford University

Recently completed

The Efficacy of Thyme Honey Mouth Rinse on Polypharmacy-induced Xerostomia (A Randomized Controlled Clinical Trial With a Biochemical Assessment)

Phase 4 · Completed · Ain Shams University

Comparison of Gum® HydralTM Moisturizing Gel and Biotene® Oral Gel in Dry Mouth Sensation Reduction: a Randomized Clinical Trial

Phase 3 · Completed · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Quality of Life in a Portuguese Population With Primary Sjögren Syndrome

Phase 4 · Completed · Grupo de Investigação em Bioquímica e Biologia Oral

A Phase II/III Study Comparing Acupuncture-like Transcutaneous Electrical Nerve Stimulation (ALTENS) Versus Pilocarpine in Treating Early Radiation-Induced Xerostomia

Phase 2/3 · Completed · Radiation Therapy Oncology Group

Effectiveness of Malic Acid 1% in Patients With Xerostomia Induced by Drugs. Determination of Salivary Mucins and Buffering Capacity

Phase 2/3 · Completed · Universidad de Granada

Comparison Study of BioXtra Spray and Mouth Rinse in Patient With Radiation-induced Xerostomia

Phase 2 · Completed · Qazvin University Of Medical Sciences

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial.

The Lancet. Oncology · 2011 · 1,166 cites

Recent publications

Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial.

The Lancet. Oncology · 2011 · 1,166 cites

Major themes1

Parotid Gland1

Leading journals1

The Lancet. Oncology1

Leading researchers8

A'Hern RP1
Adab F1
Bhide SA1
Clark C1
Emson M1
Hall E1
Harrington KJ1
Jefferies SJ1

Affiliations (unnormalised)1

Royal Marsden Hospitals NHS Foundation Trust1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Decreased salivary flow.

Identifiers

MeSHXerostomia

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
Related entities are derived from literature co-mention (studied together) — associative, not causal.