Back to discover
Drug

2,4-Thiazolidinedione

In clinical development
Emerging researchLate-stage development

Also known as Thiazolidinedione.

RxNorm84338ChEMBLCHEMBL85398UNIIAA68LXK93C
1
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A 52-Week, Open-Label, Multicenter Study to Determine the Long Term Safety and Efficacy of Albiglutide in Combination With Monotherapy of Oral Antihyperglycemic Medications in Japanese Patients With Type 2 Diabetes Mellitus

Clinical trial2017-05-03Results posted · ClinicalTrials.gov

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Phase 3 Trial to Evaluate the Safety and Efficacy of Dapagliflozin in Combination With Thiazolidinedione Therapy in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control on Thiazolidinedione Therapy Alone

Clinical trial2017-02-23Results posted · ClinicalTrials.gov

A Multi-center, Randomized, Open-label, Active Controlled, Parallel Arm Study to Compare the Efficacy of 12 Weeks of Treatment With Vildagliptin 100 mg, qd to Thiazolidinedione (TZD) as add-on Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy in a Community-based Practice Setting.

Clinical trial2016-11-18Completed · ClinicalTrials.gov

A Randomized, Placebo-controlled, 2-arm Parallel-group, Multicenter Study With a 24-week Double-blind Treatment Period Assessing the Efficacy and Safety of Lixisenatide in Patients With Type 2 Diabetes Insufficiently Controlled With Insulin Glargine and Metformin

Clinical trial2016-10-11Results posted · ClinicalTrials.gov

A 52-Week, Open-Label, Long-Term Safety Study of LY2189265 in Combination With Monotherapy of Oral Antihyperglycemic Medications in Patients With Type 2 Diabetes Mellitus

Clinical trial2015-01-29Results posted · ClinicalTrials.gov

Integrating the Genetic and Metabolic Faces of Obesity

Clinical trial2012-10-01Completed · ClinicalTrials.gov

Islet Transplantation in Type 1 Diabetic Patients Using a Steroid-free Immunosuppression Protocol and Thiazolidinedione Insulin Sensitizers

Clinical trial2011-10-01Completed · ClinicalTrials.gov

Substituting Lantus®(Insulin Glargine[rDNAorigin]Inj) for a Thiazolidinedione vs. a 3rd Oral Agent as add-on Therapy in Patients Failing a Thiazolidinedione & Sulfonylurea or Metformin Combination

Clinical trial2004-12-01Completed · ClinicalTrials.gov

PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.

Research2001-09-01Diabetes

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
2,4-Thiazolidinedione
Aliases & brands
Thiazolidinedione
RxNorm CUI
84338
ChEMBL ID
CHEMBL85398
UNII
AA68LXK93C

Clinical trials

8 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
8
registered trials across all phases
LATEST COMPLETION 2015
6
Late-stage (III+)
8
Completed
PHASE DISTRIBUTIONn = 8
Phase 12Phase 36

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

A 52-Week, Open-Label, Multicenter Study to Determine the Long Term Safety and Efficacy of Albiglutide in Combination With Monotherapy of Oral Antihyperglycemic Medications in Japanese Patients With Type 2 Diabetes Mellitus

CompletedPH IIIGlaxoSmithKlinen=3742015

A 52-Week, Open-Label, Long-Term Safety Study of LY2189265 in Combination With Monotherapy of Oral Antihyperglycemic Medications in Patients With Type 2 Diabetes Mellitus

CompletedPH IIIEli Lilly and Companyn=3942013

A Randomized, Placebo-controlled, 2-arm Parallel-group, Multicenter Study With a 24-week Double-blind Treatment Period Assessing the Efficacy and Safety of Lixisenatide in Patients With Type 2 Diabetes Insufficiently Controlled With Insulin Glargine and Metformin

CompletedPH IIISanofin=4462011

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Phase 3 Trial to Evaluate the Safety and Efficacy of Dapagliflozin in Combination With Thiazolidinedione Therapy in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control on Thiazolidinedione Therapy Alone

CompletedPH IIIAstraZenecan=9722010

A Multi-center, Randomized, Open-label, Active Controlled, Parallel Arm Study to Compare the Efficacy of 12 Weeks of Treatment With Vildagliptin 100 mg, qd to Thiazolidinedione (TZD) as add-on Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy in a Community-based Practice Setting.

CompletedPH IIIKey trialNovartis Pharmaceuticalsn=2,6652007

Recent completions

Trials that read out recently, adding to the completed evidence base.

A 52-Week, Open-Label, Multicenter Study to Determine the Long Term Safety and Efficacy of Albiglutide in Combination With Monotherapy of Oral Antihyperglycemic Medications in Japanese Patients With Type 2 Diabetes Mellitus

CompletedPH IIIGlaxoSmithKlinen=3742015

A 52-Week, Open-Label, Long-Term Safety Study of LY2189265 in Combination With Monotherapy of Oral Antihyperglycemic Medications in Patients With Type 2 Diabetes Mellitus

CompletedPH IIIEli Lilly and Companyn=3942013

Integrating the Genetic and Metabolic Faces of Obesity

CompletedPH IStanford Universityn=882012

Islet Transplantation in Type 1 Diabetic Patients Using a Steroid-free Immunosuppression Protocol and Thiazolidinedione Insulin Sensitizers

CompletedPH IUniversity of Wisconsin, Madisonn=142011

A Randomized, Placebo-controlled, 2-arm Parallel-group, Multicenter Study With a 24-week Double-blind Treatment Period Assessing the Efficacy and Safety of Lixisenatide in Patients With Type 2 Diabetes Insufficiently Controlled With Insulin Glargine and Metformin

CompletedPH IIISanofin=4462011

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Phase 3 Trial to Evaluate the Safety and Efficacy of Dapagliflozin in Combination With Thiazolidinedione Therapy in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control on Thiazolidinedione Therapy Alone

CompletedPH IIIAstraZenecan=9722010

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Major research themes2
Intercellular Signaling Peptides and Proteins1Thiazolidinediones1
Journals, researchers & institutions
Top journals
  • Diabetes1
Leading researchers
  • Funahashi T1
  • Hotta K1
  • Kihara S1
  • Kishida K1
  • Komuro R1
  • Kuriyama H1
  • Maeda N1
  • Matsuda M1
Leading institutions
free-text, unnormalised
  • Graduate School of Medicine1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials