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Drug

Abciximab

Approved medicine
ClassIntegrin alpha-IIb/beta-3 inhibitorResearchOngoing clinical research

Also known as Reopro, c7E3.

RxNorm83929ChEMBLCHEMBL1201584ATCB01AC13UNIIX85G7936GV
2
Research papers
3
Protein targets
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Exploratory Phase II Clinical Trial to Evaluate the Efficacy and Safety of Clotinab® (Abciximab) in Acute Myocardial Infarction Patients: Multicenter, Randomized, Double Blind, Placebo-controlled and Parallel Group Trial

Clinical trial2016-12-14Primary completion · ClinicalTrials.gov

Stroke Prevention With Abciximab in Carotid Endarterectomy

Clinical trial2015-12-18Withdrawn · ClinicalTrials.gov

Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis

Clinical trial2015-03-01Withdrawn · ClinicalTrials.gov

A Phase IIIb, Randomised, Open Label Trial With 3 Parallel Groups: Full Dose TNK-tPA Together With Heparin Sodium, Full Dose TNK-tPA Together With Enoxaparin, and Half Dose TNK-tPA Together With Abciximab and Heparin Sodium in Patients With Acute Myocardial Infarction: ASSENT 3 (Assessment of the Safety and Efficacy of New Thrombolytic Regimens)

Clinical trial2014-07-14Completed · ClinicalTrials.gov

A Randomized Control Trial of Intracoronary Reopro to Improve Coronary Microvascular Function

Clinical trial2014-06-01Primary completion · ClinicalTrials.gov

A Randomized Trial of Early Discharge After Trans-Radial Stenting of Coronary Arteries in Acute Myocardial Infarction and RESCUE-PCI: The EASY-RESCUE Pilot Study

Clinical trial2013-05-01Completed · ClinicalTrials.gov

A Randomized Trial to Compare Four Different Intracoronary Modalities to Reduce Thrombus Burden and Improve Microcirculatory Function in Patients With ST-elevation Myocardial Infarction: Rationale and Design of the COCTAIL II Study

Clinical trial2012-12-01Primary completion · ClinicalTrials.gov

Eptifibatide Versus Abciximab in Primary PCI for Acute ST Elevation Myocardial Infarction

Clinical trial2012-11-27Results posted · ClinicalTrials.gov

The Effect of Point-of-care Platelet Function Assay Guided Antiplatelet Therapy on the Periprocedural Increase of Cardiac Enzymes.

Clinical trial2011-10-01Completed · ClinicalTrials.gov

IntraCoronary Abciximab With the ClearWay Catheter To Improve Outcomes With Lysis

Clinical trial2011-06-01Terminated · ClinicalTrials.gov

Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: Abciximab in Emergency Treatment of Stroke Trial (AbESTT-II).

Research2007-11-21Stroke

Sustained suppression of ischemic complications of coronary intervention by platelet GP IIb/IIIa blockade with abciximab: one-year outcome in the EPILOG trial. Evaluation in PTCA to Improve Long-term Outcome with abciximab GP IIb/IIIa blockade.

Research1999-04-01Circulation

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Abciximab
Aliases & brands
Reoproc7E3
RxNorm CUI
83929
ChEMBL ID
CHEMBL1201584
ATC codes
B01AC13
UNII
X85G7936GV
Primary mechanism
Integrin alpha-IIb/beta-3 inhibitor

Pharmacology & targets

3 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

Integrin beta-3
ITGB3 · P05106
INHIBITORIntegrin alpha-IIb/beta-3 inhibitor
Integrin alpha-IIb
ITGA2B · P08514
INHIBITORIntegrin alpha-IIb/beta-3 inhibitor
Integrin alpha-V
ITGAV · P06756
INHIBITORIntegrin alpha-V/beta-3 inhibitor

Clinical trials

31 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
31
registered trials across all phases
LATEST COMPLETION 2013
26
Late-stage (III+)
17
Completed
14
Discontinued
PHASE DISTRIBUTIONn = 31
Phase 1 / 21Phase 24Phase 2 / 31Phase 310Phase 412Phase N / A3

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

A Randomized Trial of Early Discharge After Trans-Radial Stenting of Coronary Arteries in Acute Myocardial Infarction and RESCUE-PCI: The EASY-RESCUE Pilot Study

CompletedPH IVOlivier F. Bertrandn=742013

A Randomized Trial to Compare Four Different Intracoronary Modalities to Reduce Thrombus Burden and Improve Microcirculatory Function in Patients With ST-elevation Myocardial Infarction: Rationale and Design of the COCTAIL II Study

Unknown statusPH IVCLI Foundationn=1282013

The Effect of Point-of-care Platelet Function Assay Guided Antiplatelet Therapy on the Periprocedural Increase of Cardiac Enzymes.

CompletedPH IVSeoul National University Bundang Hospitaln=1302011

A Comparison of Drug Eluting and Bare Metal Stents With or Without Abciximab in ST Segment Elevation Myocardial Infarction The Eindhoven Reperfusion Study

CompletedPH IVCatharina Ziekenhuis Eindhovenn=9072009

Routine Upfront Abciximab Versus Standard Peri-Procedural Therapy in Patients Undergoing Percutaneous Coronary Intervention for Cardiogenic Shock PRAGUE-7 Trial.

CompletedPH IVCharles University, Czech Republicn=802009

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Randomized Trial of Early Discharge After Trans-Radial Stenting of Coronary Arteries in Acute Myocardial Infarction and RESCUE-PCI: The EASY-RESCUE Pilot Study

CompletedPH IVOlivier F. Bertrandn=742013

The Effect of Point-of-care Platelet Function Assay Guided Antiplatelet Therapy on the Periprocedural Increase of Cardiac Enzymes.

CompletedPH IVSeoul National University Bundang Hospitaln=1302011

Intravenous vs. Intracoronary Use of Abciximab

CompletedN/AUniversity Hospital, Gentofte, Copenhagenn=3552009

A Comparison of Drug Eluting and Bare Metal Stents With or Without Abciximab in ST Segment Elevation Myocardial Infarction The Eindhoven Reperfusion Study

CompletedPH IVCatharina Ziekenhuis Eindhovenn=9072009

Routine Upfront Abciximab Versus Standard Peri-Procedural Therapy in Patients Undergoing Percutaneous Coronary Intervention for Cardiogenic Shock PRAGUE-7 Trial.

CompletedPH IVCharles University, Czech Republicn=802009

A Randomized Trial Comparing the Efficacy on Myocardial Infarct Size Reduction of Early vs. Late Abciximab Administration During Primary Percutaneous Coronary Angioplasty

CompletedPH IVUniversity of Pisan=1102008

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19992008
Major research themes1
Angioplasty, Balloon, Coronary1
Journals, researchers & institutions
Top journals
  • Circulation1
  • Stroke1
Leading researchers
  • Adams HP Jr1
  • Anderson KM1
  • Balog C1
  • Barnathan ES1
  • Booth JE1
  • Cabot CF1
  • Califf RM1
  • Dávalos A1
Leading institutions
free-text, unnormalised
  • Carver College of Medicine1
  • The Cleveland Clinic Foundation1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials