Drug

Aceclofenac

Approved medicine

ClassCyclooxygenase-2 inhibitorResearchOngoing clinical research

Also known as Aceclofenaco, Aceclofenacum.

RxNorm16689 ChEMBLCHEMBL93645 ATCM01AB16 ATCM02AA25UNIIRPK779R03H

Prostaglandin G/H synthase 2

Primary target

Regulatory events

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Randomized, Open-label, Multiple-dose, Crossover Clinical Trial to Investigate the Pharmacokinetic Drug Interactions and Safety After Co-administration of Ilaprazole and Aceclofenac in Healthy Adults

Clinical trial2022-12-22Completed · ClinicalTrials.gov

A Randomized, Open-label, Multiple-dose, Crossover Clinical Trial to Investigate the Pharmacokinetic Drug Interactions and Safety After Co-administration of Ilaprazole and NSAID in Healthy Adults

Clinical trial2022-07-27Completed · ClinicalTrials.gov

An Open-label, Randomized, Crossover Study to Evaluate the Pharmacokinetic Interaction Between Tegoprazan and Non-steroidal Anti-inflammatory Drugs (NSAIDs) After Multiple Oral Dosing in Healthy Male Volunteers

Clinical trial2020-07-29Completed · ClinicalTrials.gov

Effect of Pre-operative Aceclofenac on the Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial

Clinical trial2017-07-01Completed · ClinicalTrials.gov

Pretreatment Aceclofenac Effect on Pain and Analgesic Intake After Endodontic Treatment: A Randomized, Double-blind, Placebo-controlled Trial

Clinical trial2017-07-01Completed · ClinicalTrials.gov

A Randomized, Open-label, Single Dose, 3-way Crossover Study to Evaluate the Drug-drug Interaction Between Aceclofenac 200 mg and Esomeprazole 20 mg in Healthy Male Volunteers

Clinical trial2017-04-16Primary completion · ClinicalTrials.gov

Drug Safety Update: Aceclofenac (Preservex): updated cardiovascular advice in line with diclofenac and COX-2 inhibitors

Regulatory2015-01-22MHRA

A Comparison of Tramadol/Acetaminophen Tablets Maintenance Versus NSAID Maintenance After Tramadol/Acetaminophen and NSAID Combination Therapy in Knee Osteoarthritis Patients: Multicenter, Randomized, Open Comparative Study

Clinical trial2013-07-22Results posted · ClinicalTrials.gov

Comparison of Lower Dosage of Etoricoxib Versus Aceclofenac in the Treatment of Patients With Rheumatoid Arthritis: A Single-center, Parallel-group, Randomized Controlled Pilot Study

Clinical trial2007-07-31Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Aceclofenac

Aliases & brands

AceclofenacoAceclofenacum

RxNorm CUI

16689

ChEMBL ID

CHEMBL93645

ATC codes

M01AB16M02AA25

UNII

RPK779R03H

Primary mechanism

Cyclooxygenase-2 inhibitor

Regulatory jurisdictions

mhra

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Prostaglandin G/H synthase 2

PTGS2 · P35354

INHIBITORCyclooxygenase-2 inhibitor

Regulatory timeline

1 event

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Authorities

MHRA

Total events

mhraMedicines and Healthcare products Regulatory Agency· 1 event

2015-01-22Safety communicationSafety

Drug Safety Update: Aceclofenac (Preservex): updated cardiovascular advice in line with diclofenac and COX-2 inhibitors

Evidence ↗

Contains public sector information from the Medicines and Healthcare products Regulatory Agency (MHRA) licensed under the Open Government Licence (OGL v3).