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Drug

Acetaminophen

Approved · FDA
Emerging researchLate-stage developmentSteady momentum
Also known as 4'-hydroxyacetanilide, 4-(Acetylamino)phenol, 4-acetamidophenol, APAP+342 more

4'-hydroxyacetanilide, 4-(Acetylamino)phenol, 4-acetamidophenol, APAP, Acenol, Acephen, Aceta, Acetadryl, Acetaminophen-Benzhydrocodone, Acetaminophen-Butalbital, Acetaminophen-Caffeine, Acetaminophen-Pentazocine, Acetaminophen-Pseudoephedrine, Actamin, Acuflex, Adprin B, Alagesic, Ali-Flex, Alidrin, Allay, Allzital, Alpain, Altenol, Americet, Amidrine, Anabar, Anacin AF, Anacin Advanced Headache Formula, Anacin-3 Maximum Strength, Anexsia, Anolor 300, Anolor DH5, Anoquan, Apacet, Apadaz, Apagesic, Apapgesic, Apara, Apra, Arcet, Arthriten, Arthriten Inflammatory Pain, Axocet, BP Poly-650, Backaid, Backaid IPF, Backprin, Bactimicina, Balacet, Bancap HC, Bromo Seltzer, Bucet, Bupap, Butex Forte, By Ache, By-Ache, Cafgesic, Calpol Six Plus, Capacet, Cephadyn, Ceta Plus, Cetafen, Co-Gesic, Cocet, Colrex, Combiflex, Combiflex ES, Combogesic, Comtrex Sore Throat Relief, Conacetol, Contragesic, Cotabflu, CounterAct Pain, Dolacet, Dolagesic, Dolgic, Dolgic LQ, Dolgic Plus, Dolmar, Dologesic, Dologesic DF, Dolono, Dolono Infant, Dolorex, Dolorex Forte, Duocet, Duogesic, Durabac, Durabac Forte, Duradrin, Dvorah, EZ III, Ed Flex, Ed-Flex, Endocet, Endolor, Epidrin, Esgic, Ex-Pain, Exaprin, Exaprin Plus, Excedrin, Excedrin Back and Body, Excedrin Extra Strength Geltab, Excedrin Migraine Geltab, Excedrin Mild Headache, Excedrin PM, Excedrin PM Triple Action, Excedrin Quick Tab, Excedrin Tension Headache, Ezol, Femcet, Feverall, Fioricet, Fioricet with Codeine, Fiorpap, Flextra Plus, Fortolin, Frenadol, G-1, Genace, Genapap, Genapap Extra Strength, Genapap PM, Genasec, Genebs, Geone, Gericet, Halenol, Hy-Phen, Hycet, Hyco-pap, Hycomed, Hycomine Compound, Hydrocet, Hydrogesic, I.D.A., Ide-cet, Infadrops, Infantaire, Iso-Acetazone, Isocet, Isocom, Lagesic, Legatrin PM, Levacet, Liquicet, Liquiprin, Little Fevers, Lobac, Lopap, Lorcet, Lortab, Lurline PMS, Magnacet, Major-gesic, Mapap, Mapap Junior Strength, Mapap PM, Mardol, Margesic, Margesic #3, Margesic-H, Marten-Tab, Masophen, Masophen PM, Maxidone, Maxiflu CD, Meda Cap, Medigesic, Medinol Paediatric, Medipain 5, Midchlor, Midrin, Migquin, MigraTen, Migrapap, Migratine, Migrazone, Migrex, Minotal, Mitride, Mygracet, N-acetyl-p-aminophenol, Nalocet, Narvox, Neopap Supprettes, Ninjacof A, Ninjacof-A, Nodolor, Nonbac, Norco, Nortemp, Ofirmev, Oncet, Orbivan, Orbivan CF, PANADOL, Pacaps, Pain-Eze, Pain-Gesic, Paldesic, Pamprin Cramp Formula, Pamprin Max Formula, Pamprin Multi-Symptom, Panacet, Panadol Childrens, Panadol Extra, Panadol PM, Panex, Panex 500, Panlor, Panlor DC, Panlor SS, Panlor Tablet, Panritis Forte, Paracetamol, Paracetamolum, Paracets, Paramol, Pediapap, Pediaphen, Percocet, Percogesic, Percogesic Reformulated Jan 2011, Perisine, Perloxx, Pharbetol, Pharmagesic, Phenagesic, Phenaphen with Codeine, Phenylgesic, Phrenilin, Phrenilin Forte, Phrenilin with Caffeine and Codeine, Polygesic, Premsyn PMS, Primalev, Primlev, Procet, Prodrin, Prolate, Promacet, Prominol, Q-Gesic, Q-Nol, Redutemp, Relagesic, Repan, Repan CF, RhinoFlex, Rid-A-Pain, Ridenol, Ringl, Roxicet, Roxilox, S-T Febrol, Saleto, Sed-Max, Sedapap, St. Joseph Aspirin-Free, Staflex, Staflex (phenyltoloxamine), Stagesic, Supac, T-Gesic, T-Painol, T-Panol, Tactinal, Talacen, Tempra, Tempra 1, Tempra 2, Tempra 3, Tempra Quicklets, Tenake, Tencet, Tencon, Trezix, Triad, Triaprin, Two-Dyne, Tycolene, Tylenol, Tylenol Cold Relief Nighttime Caplet, Tylenol Gelcap Extra Strength, Tylenol PM, Tylenol Womens Menstrual Relief, Tylenol with Codeine, Tylophen, Tylox, Ugesic, Ultracet, Uni-Ace, Uni-Ace Child, Uni-Case, Uni-Perr, Uniserts, Unisom with Pain Relief, Uricalm Intensive, Va-zone, Valorin Extra, Vanacet, Vanatol, Vanatol LQ, Vanatol S, Vanquish, Vendone, Verdrocet, Vicodin, Vistra, Vitapap, Vitoxapap, Vopac, Vtol, Wygesic, XS No Aspirin PR, XS Pain Reliever, Xodol, Xolox, Zamicet, Zebutal, Zerlor, Zgesic, Zolvit, Zydone, p-Acetylaminophenol, p-acetamidophenol, p-acetaminophenol, p-hydroxy-acetanilid, p-hydroxyacetanilide, Acetaminophen-Ibuprofen, Acetaminofén, APAP/Dichloralphenazone/Isometheptene, Acetaminophen-Propoxyphene Hydrochloride, Acetaminophen/Aspirin/Caffeine, Acetaminophen/Butalbital/Caffeine, Acetaminophen/Butalbital/Caffeine/Codeine, Elixsure Fever/Pain, Percocet 10/325, Percocet 10/650, Percocet 2.5/325, Percocet 5/325, Percocet 7.5/325, Percocet 7.5/500, Phenyltoloxamine/APAP.

12
Research papers
17
Active clinical trials
888
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Acetaminophen
Aliases & brands
4'-hydroxyacetanilide4-(Acetylamino)phenol4-acetamidophenolAPAPAcenolAcephenAcetaAcetadrylAcetaminophen-BenzhydrocodoneAcetaminophen-ButalbitalAcetaminophen-CaffeineAcetaminophen-PentazocineAcetaminophen-PseudoephedrineActaminAcuflexAdprin BAlagesicAli-FlexAlidrinAllayAllzitalAlpainAltenolAmericetAmidrineAnabarAnacin AFAnacin Advanced Headache FormulaAnacin-3 Maximum StrengthAnexsiaAnolor 300Anolor DH5AnoquanApacetApadazApagesicApapgesicAparaApraArcetArthritenArthriten Inflammatory PainAxocetBP Poly-650BackaidBackaid IPFBackprinBactimicinaBalacetBancap HCBromo SeltzerBucetBupapButex ForteBy AcheBy-AcheCafgesicCalpol Six PlusCapacetCephadynCeta PlusCetafenCo-GesicCocetColrexCombiflexCombiflex ESCombogesicComtrex Sore Throat ReliefConacetolContragesicCotabfluCounterAct PainDolacetDolagesicDolgicDolgic LQDolgic PlusDolmarDologesicDologesic DFDolonoDolono InfantDolorexDolorex ForteDuocetDuogesicDurabacDurabac ForteDuradrinDvorahEZ IIIEd FlexEd-FlexEndocetEndolorEpidrinEsgicEx-PainExaprinExaprin PlusExcedrinExcedrin Back and BodyExcedrin Extra Strength GeltabExcedrin Migraine GeltabExcedrin Mild HeadacheExcedrin PMExcedrin PM Triple ActionExcedrin Quick TabExcedrin Tension HeadacheEzolFemcetFeverallFioricetFioricet with CodeineFiorpapFlextra PlusFortolinFrenadolG-1GenaceGenapapGenapap Extra StrengthGenapap PMGenasecGenebsGeoneGericetHalenolHy-PhenHycetHyco-papHycomedHycomine CompoundHydrocetHydrogesicI.D.A.Ide-cetInfadropsInfantaireIso-AcetazoneIsocetIsocomLagesicLegatrin PMLevacetLiquicetLiquiprinLittle FeversLobacLopapLorcetLortabLurline PMSMagnacetMajor-gesicMapapMapap Junior StrengthMapap PMMardolMargesicMargesic #3Margesic-HMarten-TabMasophenMasophen PMMaxidoneMaxiflu CDMeda CapMedigesicMedinol PaediatricMedipain 5MidchlorMidrinMigquinMigraTenMigrapapMigratineMigrazoneMigrexMinotalMitrideMygracetN-acetyl-p-aminophenolNalocetNarvoxNeopap SupprettesNinjacof ANinjacof-ANodolorNonbacNorcoNortempOfirmevOncetOrbivanOrbivan CFPANADOLPacapsPain-EzePain-GesicPaldesicPamprin Cramp FormulaPamprin Max FormulaPamprin Multi-SymptomPanacetPanadol ChildrensPanadol ExtraPanadol PMPanexPanex 500PanlorPanlor DCPanlor SSPanlor TabletPanritis ForteParacetamolParacetamolumParacetsParamolPediapapPediaphenPercocetPercogesicPercogesic Reformulated Jan 2011PerisinePerloxxPharbetolPharmagesicPhenagesicPhenaphen with CodeinePhenylgesicPhrenilinPhrenilin FortePhrenilin with Caffeine and CodeinePolygesicPremsyn PMSPrimalevPrimlevProcetProdrinProlatePromacetProminolQ-GesicQ-NolRedutempRelagesicRepanRepan CFRhinoFlexRid-A-PainRidenolRinglRoxicetRoxiloxS-T FebrolSaletoSed-MaxSedapapSt. Joseph Aspirin-FreeStaflexStaflex (phenyltoloxamine)StagesicSupacT-GesicT-PainolT-PanolTactinalTalacenTempraTempra 1Tempra 2Tempra 3Tempra QuickletsTenakeTencetTenconTrezixTriadTriaprinTwo-DyneTycoleneTylenolTylenol Cold Relief Nighttime CapletTylenol Gelcap Extra StrengthTylenol PMTylenol Womens Menstrual ReliefTylenol with CodeineTylophenTyloxUgesicUltracetUni-AceUni-Ace ChildUni-CaseUni-PerrUnisertsUnisom with Pain ReliefUricalm IntensiveVa-zoneValorin ExtraVanacetVanatolVanatol LQVanatol SVanquishVendoneVerdrocetVicodinVistraVitapapVitoxapapVopacVtolWygesicXS No Aspirin PRXS Pain RelieverXodolXoloxZamicetZebutalZerlorZgesicZolvitZydonep-Acetylaminophenolp-acetamidophenolp-acetaminophenolp-hydroxy-acetanilidp-hydroxyacetanilideAcetaminophen-IbuprofenAcetaminofénAPAP/Dichloralphenazone/IsomethepteneAcetaminophen-Propoxyphene HydrochlorideAcetaminophen/Aspirin/CaffeineAcetaminophen/Butalbital/CaffeineAcetaminophen/Butalbital/Caffeine/CodeineElixsure Fever/PainPercocet 10/325Percocet 10/650Percocet 2.5/325Percocet 5/325Percocet 7.5/325Percocet 7.5/500Phenyltoloxamine/APAP
RxNorm CUI
161
ChEMBL ID
CHEMBL112
UNII
362O9ITL9D
Regulatory jurisdictions
fda

Regulatory timeline

888 events

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
1981-08-21
Latest approval
2026-06-18
Authorities
FDA
Total events
888
fdaU.S. Food and Drug Administration· 888 events
2026-06-18Supplemental approval
Supplemental approval: BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (ANDA076560)
Evidence ↗
2026-06-18Supplemental approval
Supplemental approval: HYDROCODONE BITARTRATE AND ACETAMINOPHEN (ANDA040746)
Evidence ↗
2026-06-18Supplemental approval
Supplemental approval: BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (NDA020232)
Evidence ↗

Data from the U.S. Food and Drug Administration (U.S. Food and Drug Administration), public domain (CC0).

Clinical trials

188 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
188
registered trials across all phases
LATEST COMPLETION 2026
17
Active studies
11
Recruiting
131
Late-stage (III+)
120
Completed
51
Discontinued
PHASE DISTRIBUTIONn = 188
Early Phase 14Phase 118Phase 1 / 26Phase 229Phase 2 / 34Phase 323Phase 471Phase N / A33

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

12 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19992023
Most influential
Recent papers
Major research themes8
Analgesics, Non-Narcotic2Laparoscopy2Administration, Oral1Administration, Rectal1Analgesia, Obstetrical1Analgesia, Patient-Controlled1Anesthesia, General1Cesarean Section1
Journals, researchers & institutions
Top journals
  • Pain practice : the official journal of World Institute of Pain2
  • Acta anaesthesiologica Scandinavica1
  • British journal of anaesthesia1
  • Canadian journal of anaesthesia = Journal canadien d'anesthesie1
  • Clinical therapeutics1
  • Frontiers in pharmacology1
Leading researchers
  • Royal MA3
  • Singla NK2
  • Aijazi H1
  • Alhashemi JA1
  • Alotaibi QA1
  • Ang R1
  • Ang RY1
  • Artime CA1
Leading institutions
free-text, unnormalised
  • Albany Medical College1
  • and Pain Medicine University of Texas1
  • Group Health Research Institute1
  • King Abdulaziz University1
  • Lotus Clinical Research LLC1
  • McGovern Medical School1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.