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Drug

Acetylglucosamine

In clinical development
Emerging researchLate-stage development
Also known as 2-Acetamido-2-deoxy-D-glucose, D-GlcNAc, N-ACETYLGLUCOSAMINE, N-Acetyl-D-glucosamine+3 more

2-Acetamido-2-deoxy-D-glucose, D-GlcNAc, N-ACETYLGLUCOSAMINE, N-Acetyl-D-glucosamine, N-Acetylchitosamine, aldehydo-N-acetyl-D-glucosamine, ACETYL GLUCOSAMINE.

RxNorm1362871ChEMBLCHEMBL4303483UNIIV956696549
2
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

The NAGIC Study: Multi-center, Randomized, Double-blind, Placebo-controlled Cross-over Study of Oral N-acetylglucosamine in Ileal/Ileocolonic Crohn's Disease

Clinical trial2026-05-12Results expected Q3 2028 · ClinicalTrials.gov

Regulation of protein O-GlcNAcylation by circadian, metabolic, and cellular signals.

Research2023-12-29The Journal of biological chemistry

N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial.

Research2023-09-13Journal of neuroinflammation

Immunologic Effects of Supplemental Monosaccharide and Nucleoside Derivatives in Patients With Inherited Disorders of Glycosylation

Clinical trial2017-01-24Terminated · ClinicalTrials.gov

Multicenter Randomized Double-blind Placebo-controlled Clinical Trials to Evaluate the Clinical Efficacy and Safety of N-acetyl Glucosamine Capsule for Irritable Bowel Syndrome With Diarrhea (IBS-D) Treatment

Clinical trial2016-12-01Primary completion · ClinicalTrials.gov

Multicenter Randomized Withdrawal Clinical Trials of N-acetyl Glucosamine Capsule for Irritable Bowel Syndrome With Diarrhea (IBS-D) Treatment

Clinical trial2016-12-01Primary completion · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Acetylglucosamine
Aliases & brands
2-Acetamido-2-deoxy-D-glucoseD-GlcNAcN-ACETYLGLUCOSAMINEN-Acetyl-D-glucosamineN-Acetylchitosaminealdehydo-N-acetyl-D-glucosamineACETYL GLUCOSAMINE
RxNorm CUI
1362871
ChEMBL ID
CHEMBL4303483
UNII
V956696549

Clinical trials

4 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
4
registered trials across all phases
1
Active studies
1
Recruiting
2
Late-stage (III+)
3
Discontinued
PHASE DISTRIBUTIONn = 4
Phase 11Phase 21Phase 2 / 31Phase 31

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Multicenter Randomized Double-blind Placebo-controlled Clinical Trials to Evaluate the Clinical Efficacy and Safety of N-acetyl Glucosamine Capsule for Irritable Bowel Syndrome With Diarrhea (IBS-D) Treatment

Unknown statusPH IIIThird Military Medical Universityn=7202017

Multicenter Randomized Withdrawal Clinical Trials of N-acetyl Glucosamine Capsule for Irritable Bowel Syndrome With Diarrhea (IBS-D) Treatment

Unknown statusPH II/IIIThird Military Medical Universityn=1802017

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20232024
Major research themes5
Circadian Clocks1Encephalitis1Multiple Sclerosis1Protein Processing, Post-Translational1Signal Transduction1
Journals, researchers & institutions
Top journals
  • Journal of neuroinflammation1
  • The Journal of biological chemistry1
Leading researchers
  • Brandt AU1
  • Cai YD1
  • Chiu JC1
  • Cordon A1
  • Demetriou M1
  • Dennis JW1
  • Hayama KL1
  • Kuhle J1
Leading institutions
free-text, unnormalised
  • College of Agricultural and Environmental Sciences1
  • Donald Bren School of Information and Computer Sciences1
  • Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB)1
  • Samuel Lunenfeld Research Institute1
  • University Hospital Basel1
  • University of California Irvine1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Glatiramer Acetate

Studied across 3 of the same disease areas as Acetylglucosamine in the shared literature.

3 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials