Drug

Albuterol

In clinical development

Emerging researchLate-stage developmentRising momentum

Also known as Accuneb, Airet, Airsupra, Combivent+9 more

Accuneb, Airet, Airsupra, Combivent, DuoNeb, ProAir, ProAir HFA, Proventil, Salbutamol, Salbutamolum, Ventolin, Volmax, Albuterol Sulfate.

RxNorm435 ChEMBLCHEMBL714UNIIQF8SVZ843E

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Randomized, Double-Blind, Multicenter, Active-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Fixed-Dose Combination on Severe Asthma Exacerbations in Patients With Asthma

Clinical trial2026-07-24Results expected Q4 2026 · ClinicalTrials.gov

Lung Anatomic, Physiologic, and Inflammatory Changes With Chronic Exposure to Secondhand Tobacco Smoke

Clinical trial2026-06-04Results expected Q4 2026 · ClinicalTrials.gov

A Double-blind Placebo-controlled Crossover Study to Assess the Effects of Bronchodilation on Dyspnea, Ventilatory Responses, and Exercise Tolerance in Adults With Cystic Fibrosis

Clinical trial2026-05-15Results expected Q4 2027 · ClinicalTrials.gov

The Role Intraoperative Salbutamol Inhaler Usage as Part of Intraoperative Regimen in Preventing Atelectasis Following Thoracic, Abdominal and Spinal Surgery in Diabetics Population

Clinical trial2026-05-15Results expected Q4 2026 · ClinicalTrials.gov

48-week, Multicentre, Multinational, Randomized, Double-blind, 2-arm Parallel Group, Comparing the Efficacy of FOSTER for Maintenance & Reliever Versus Fixed-dose FOSTER for Maintenance + Salbutamol as Reliever in Asthmatics ≥ 18 Years of Age

Clinical trial2026-05-07Results posted · ClinicalTrials.gov

Ventilation and Perfusion in Individuals With Asthma

Clinical trial2026-05-05Results expected Q2 2028 · ClinicalTrials.gov

Dose Escalation Clinical Trial of High-dose Oral Montelukast to Inform Future RCT in Children With Acute Asthma Exacerbations

Clinical trial2026-03-26Completed · ClinicalTrials.gov

CONNected Electronic Inhalers Asthma Control Trial 1 ("CONNECT 1"), a 12-Week Treatment, Multicenter, Open-Label, Randomized, Parallel Group Comparison, Feasibility Study to Evaluate the Effectiveness of the Albuterol eMDPI Digital System, to Optimize Outcomes in Patients at Least 13 Years of Age or Older With Asthma

Clinical trial2026-03-19Results posted · ClinicalTrials.gov

Beclometasone-formoterol as maintenance and reliever treatment in patients with asthma: a double-blind, randomised controlled trial.

Research2013-03-04The Lancet. Respiratory medicine

Effects of an inhaled β2-agonist on cardiovascular function and sympathetic activity in healthy subjects.

Research2011-08-01Pharmacotherapy

Influence of genetic variation of the β2-adrenergic receptor on lung diffusion in patients with cystic fibrosis.

Research2011-06-15Pulmonary pharmacology & therapeutics

Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial.

Research2011-02-14Lancet (London, England)

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Albuterol

Aliases & brands

AccunebAiretAirsupraCombiventDuoNebProAirProAir HFAProventilSalbutamolSalbutamolumVentolinVolmaxAlbuterol Sulfate

RxNorm CUI

435

ChEMBL ID

CHEMBL714

UNII

QF8SVZ843E

Clinical trials

169 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

169

registered trials across all phases

LATEST COMPLETION 2026

Active studies

Recruiting

128

Late-stage (III+)

117

Completed

Discontinued

PHASE DISTRIBUTIONn = 169

Early Phase 13Phase 118Phase 1 / 21Phase 219Phase 2 / 33Phase 332Phase 445Phase N / A48

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Ventilation and Perfusion in Individuals With Asthma

RecruitingPH IVUniversity of Miamin=402028

Lung Anatomic, Physiologic, and Inflammatory Changes With Chronic Exposure to Secondhand Tobacco Smoke

Active, not recruitingPH IVUniversity of California, San Franciscon=1072026

InSaKa Trial: Insulin Dextrose Infusion Versus Nebulized Salbutamol Versus Combination of Salbutamol and Insulin Dextrose in Acute Hyperkalemia: a Randomized Clinical Trial

CompletedPH IVNantes University Hospitaln=4192025

Comparison of Preoperative Inhaled Budesonide With Salbutamol on the Respiratory Adverse Effects in Children Undergoing Tonsillectomy

Unknown statusPH IVAssiut Universityn=872025

5 Versus 10 Units of Insulin in Hyperkalemia Management: Multi-center, Prospective, Double-blind, Non-inferiority, Randomized Control Trial.

CompletedPH IVOman Medical Speciality Boardn=3842025

Recent completions

Trials that read out recently, adding to the completed evidence base.

Dose Escalation Clinical Trial of High-dose Oral Montelukast to Inform Future RCT in Children With Acute Asthma Exacerbations

CompletedPH IIVanderbilt University Medical Centern=902026

InSaKa Trial: Insulin Dextrose Infusion Versus Nebulized Salbutamol Versus Combination of Salbutamol and Insulin Dextrose in Acute Hyperkalemia: a Randomized Clinical Trial

CompletedPH IVNantes University Hospitaln=4192025

5 Versus 10 Units of Insulin in Hyperkalemia Management: Multi-center, Prospective, Double-blind, Non-inferiority, Randomized Control Trial.

CompletedPH IVOman Medical Speciality Boardn=3842025

Cardiovascular Consequences of Prolonged Inhaled Short-acting Beta-agonist Use in Healthy Participants

CompletedPH IUniversity of Albertan=812025

The Effect of Adding Nebulized Epinephrine in Asthma Exacerbation Management in Pediatric Age Group Compared to Standard of Care: Superiority Trial

CompletedPH IVOman Medical Speciality Boardn=302025

COMPIS- Congenital Myopathy Intervention Study. An Open-label, Cross Over, Randomised, Controlled Study Using Oral Salbutamol

CompletedN/AVastra Gotaland Regionn=182025

Research activity

5 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20082013

Most influential

Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial.

Lancet (London, England) · 2011 · 232 cites

Beclometasone-formoterol as maintenance and reliever treatment in patients with asthma: a double-blind, randomised controlled trial.

The Lancet. Respiratory medicine · 2013 · 107 cites

Population pharmacodynamic model of bronchodilator response to inhaled albuterol in children and adults with asthma.

Chest · 2008 · 27 cites

Effects of an inhaled β2-agonist on cardiovascular function and sympathetic activity in healthy subjects.

Pharmacotherapy · 2011 · 24 cites

Influence of genetic variation of the β2-adrenergic receptor on lung diffusion in patients with cystic fibrosis.

Pulmonary pharmacology & therapeutics · 2011 · 3 cites