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Drug

alpha-Linolenic Acid

In clinical development
Emerging researchLate-stage development
Also known as ALA, LINOLENIC ACID, Octadecatrienoic acid, Alpha linolenic acid+8 more

ALA, LINOLENIC ACID, Octadecatrienoic acid, Alpha linolenic acid, (9,12,15)-linolenic acid, (9Z,12Z,15Z)-Octadecatrienoic acid, (Z,Z,Z)-9,12,15-octadecatrienoic acid, 9,12,15-Octadecatrienoic acid, 9-cis,12-cis,15-cis-octadecatrienoic acid, all-cis-9,12,15-Octadecatrienoic acid, cis,cis,cis-9,12,15-Octadecatrienoic acid, cis-delta(9,12,15)-Octadecatrienoic acid.

RxNorm52071ChEMBLCHEMBL8739UNII0RBV727H71
1
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Alteration of the Immune Microenvironment in Basal Cell Carcinoma (BCC) Following Photodynamic Therapy (PDT)

Clinical trial2026-06-01Results expected Q3 2027 · ClinicalTrials.gov

Aminolevulinic Acid-photodynamic Therapy for Facial Actinic Keratosis Treatment and Prevention: A Long-term (3 Years) Follow-up of Prospective, Randomized, Multicenter-clinical Trial

Clinical trial2025-06-01Primary completion · ClinicalTrials.gov

Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome.

Research2024-04-30International journal of molecular sciences

A Randomized Controlled Trial Evaluating 5-aminolevulinic Acid Photodynamic Therapy With Different Incubation Times for the Treatment of Actinic Keratosis

Clinical trial2023-08-30Completed · ClinicalTrials.gov

A Phase 2 Study of the Effect of Microneedle Lesion Preparation, Incubation Time and Light Power Density on Photodynamic Therapy With Levulan Kerastick (Aminolevulinic Acid HCl) for Topical Solution, 20% + Blue Light for the Field Treatment of Actinic Keratoses on the Face

Clinical trial2018-01-18Results posted · ClinicalTrials.gov

A RANDOMIZED, VEHICLE-CONTROLLED PHASE 3 STUDY TO PROVE THE SAFETY AND EFFICACY OF LEVULAN KERASTICK (AMINOLEVULINIC ACID HCl) FOR TOPICAL SOLUTION, 20% AND 10 J/CM2 OF BLUE LIGHT DELIVERED AT 10 MW/CM2 OR 20 MW/CM2 BY A NEW LIGHT SOURCE FOR THE TREATMENT OF ACTINIC KERATOSES ON THE FACE OR SCALP

Clinical trial2018-01-01Withdrawn · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
alpha-Linolenic Acid
Aliases & brands
ALALINOLENIC ACIDOctadecatrienoic acidAlpha linolenic acid(9,12,15)-linolenic acid(9Z,12Z,15Z)-Octadecatrienoic acid(Z,Z,Z)-9,12,15-octadecatrienoic acid9,12,15-Octadecatrienoic acid9-cis,12-cis,15-cis-octadecatrienoic acidall-cis-9,12,15-Octadecatrienoic acidcis,cis,cis-9,12,15-Octadecatrienoic acidcis-delta(9,12,15)-Octadecatrienoic acid
RxNorm CUI
52071
ChEMBL ID
CHEMBL8739
UNII
0RBV727H71

Clinical trials

5 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
5
registered trials across all phases
LATEST COMPLETION 2023
1
Active studies
3
Late-stage (III+)
2
Completed
2
Discontinued
PHASE DISTRIBUTIONn = 5
Phase 22Phase 31Phase 41Phase N / A1

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Major research themes2
alpha-Linolenic Acid1Metabolic Syndrome1
Journals, researchers & institutions
Top journals
  • International journal of molecular sciences1
Leading researchers
  • Girek Z1
  • Jovanović P1
  • Jovanović V1
  • Pavlović S1
  • Ranković S1
  • Šarac I1
  • Takić M1
Leading institutions
free-text, unnormalised
  • Centre of Research Excellence in Nutrition and Metabolism1
  • Department of Biochemistry and Centre of Excellence for Molecular Food Sciences1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials