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Drug

Aluminum Hydroxide

In clinical development
Emerging researchLate-stage development
Also known as Acid Gone, Acid Gone Antacid, Alamag, Alamag Plus+69 more

Acid Gone, Acid Gone Antacid, Alamag, Alamag Plus, Alenic Alka, Alginic Compound, Almacone, Aloh-Gel, Alternagel, Alu-Cap, Alu-Tab, Aluminio hidróxido, Amphojel, Balanta, Balox Plus, Basaljel, Comfort Gel, Derma Gran, Di-Gel, Dialume, Dixlanta, Foamicon, Gaviscon, Gaviscon Chewable, Gaviscon-2, Gelusil, Gen-Alox, Gen-Lanta, Genaton, Genaton Chewable, Kudrox, M.A.H., Maalox, Maalox Max, Maalox Plus, Magaant, Magagel, Magagel Plus, Magalox Plus, Magnalox, Maldroxal, Maldroxal Plus, Masanti, Mi-Acid, Milantex, Mintox, Mintox Plus, Mygel, Mygel II, Mylagel, Mylagel II, Mylagen, Mylagen-II, Nephrox, Ri-Mox, Ri-Mox Plus, Simaal Gel, Tempo, Uni-Antacid, Uni-Lan, Urban, Urban DS, Valu-Foam, Valumag Plus, alumina hydrate, hydrated alumina, ALUMINUM (AS HYDROXIDE), Aluminium hydroxide, Aluminum Hydroxide Gel, Al hydroxide/Mg hydroxide/Simethicone, Aluminum Hydroxide-Magnesium Hydroxide, Aluminum Hydroxide/Magnesium Hydroxide/Simethicone, Low Sodium Plus.

RxNorm612ChEMBLCHEMBL1200706ATCA02AB01UNII5QB0T2IUN0
1
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Phase I Trial of the Safety and Immunogenicity of MN rsgp120/HIV-1 With the Adjuvants QS-21 and Alum Compared to MN rsgp120/HIV-1 and QS-21 in Infants Born to HIV-Infected Women

Clinical trial2021-10-29Withdrawn · ClinicalTrials.gov

Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes: Interim Analysis of 2 Randomized Clinical Trials.

Research2020-09-01JAMA

Effects of Recombinant Human Glutamic Acid Decarboxylase (rhGAD65) Formulated in Alum (GAD-alum) on the Progression of Type 1 Diabetes in New Onset Subjects

Clinical trial2020-05-07Results posted · ClinicalTrials.gov

Phase I Study of the Safety and Immunogenicity of Recombinant Staphylococcal Enterotoxin B Vaccine (STEBVax) in Healthy Adults

Clinical trial2015-03-01Completed · ClinicalTrials.gov

Phase I, Double-Blinded, Placebo-Controlled Dosage Escalation Study of the Safety and Immunogenicity of Adjuvanted and Non-Adjuvanted Inactivated SARS Coronavirus (SARS-CoV) Vaccine Administered by the Intramuscular Route

Clinical trial2012-01-01Withdrawn · ClinicalTrials.gov

Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial

Clinical trial2009-03-10Completed · ClinicalTrials.gov

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Clinical Trial of the Safety, Reactogenicity, and Immunogenicity of Intramuscular Immunization With Inactivated, Vero Cell-Culture Derived Influenza A/H5N1 Vaccine Given Alone or With Aluminum Hydroxide to Healthy Young Adults

Clinical trial2007-09-01Completed · ClinicalTrials.gov

A Phase I-II, Randomized, Controlled, Dose-Ranging Study of the Safety, Reactogenicity, and Immunogenicity of Intramuscular Inactivated Influenza A/H5N1 Vaccine Given Alone or With Aluminum Hydroxide to Healthy Elderly Adults

Clinical trial2007-03-01Completed · ClinicalTrials.gov

A Phase I-II, Randomized, Controlled, Dose-Ranging Study of the Safety, Reactogenicity, and Immunogenicity of Intramuscular Inactivated Influenza A/H5N1 Vaccine Given Alone or With Aluminum Hydroxide to Healthy Adults

Clinical trial2006-12-01Completed · ClinicalTrials.gov

A Randomized, Placebo-Controlled, Phase I/II, Dose-Ranging Study of the Safety, Reactogenicity, and Immunogenicity of Intramuscular Inactivated Influenza A/H5N1 Vaccine Given Alone or Combined With Adjuvants in Healthy Adults

Clinical trial2006-11-01Completed · ClinicalTrials.gov

Parathyroid Hormone Levels in Relation to the Phosphorus Content of Meals

Clinical trial2005-06-24Completed · ClinicalTrials.gov

Phase I/II Trial to Evaluate the Safety and Immunogenicity of AIDSVAX B/B and B/E Vaccines in the United States

Clinical trial2005-06-24Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Aluminum Hydroxide
Aliases & brands
Acid GoneAcid Gone AntacidAlamagAlamag PlusAlenic AlkaAlginic CompoundAlmaconeAloh-GelAlternagelAlu-CapAlu-TabAluminio hidróxidoAmphojelBalantaBalox PlusBasaljelComfort GelDerma GranDi-GelDialumeDixlantaFoamiconGavisconGaviscon ChewableGaviscon-2GelusilGen-AloxGen-LantaGenatonGenaton ChewableKudroxM.A.H.MaaloxMaalox MaxMaalox PlusMagaantMagagelMagagel PlusMagalox PlusMagnaloxMaldroxalMaldroxal PlusMasantiMi-AcidMilantexMintoxMintox PlusMygelMygel IIMylagelMylagel IIMylagenMylagen-IINephroxRi-MoxRi-Mox PlusSimaal GelTempoUni-AntacidUni-LanUrbanUrban DSValu-FoamValumag Plusalumina hydratehydrated aluminaALUMINUM (AS HYDROXIDE)Aluminium hydroxideAluminum Hydroxide GelAl hydroxide/Mg hydroxide/SimethiconeAluminum Hydroxide-Magnesium HydroxideAluminum Hydroxide/Magnesium Hydroxide/SimethiconeLow Sodium Plus
RxNorm CUI
612
ChEMBL ID
CHEMBL1200706
ATC codes
A02AB01
UNII
5QB0T2IUN0

Clinical trials

19 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
19
registered trials across all phases
LATEST COMPLETION 2015
3
Late-stage (III+)
17
Completed
2
Discontinued
PHASE DISTRIBUTIONn = 19
Phase 111Phase 1 / 24Phase 21Phase 31Phase N / A2

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial

CompletedPH IIIEl Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarezn=492009

Recent completions

Trials that read out recently, adding to the completed evidence base.

Phase I Study of the Safety and Immunogenicity of Recombinant Staphylococcal Enterotoxin B Vaccine (STEBVax) in Healthy Adults

CompletedPH INational Institute of Allergy and Infectious Diseases (NIAID)n=292015

Effects of Recombinant Human Glutamic Acid Decarboxylase (rhGAD65) Formulated in Alum (GAD-alum) on the Progression of Type 1 Diabetes in New Onset Subjects

CompletedPH IINational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)n=1452012

Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial

CompletedPH IIIEl Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarezn=492009

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Clinical Trial of the Safety, Reactogenicity, and Immunogenicity of Intramuscular Immunization With Inactivated, Vero Cell-Culture Derived Influenza A/H5N1 Vaccine Given Alone or With Aluminum Hydroxide to Healthy Young Adults

CompletedPH INational Institute of Allergy and Infectious Diseases (NIAID)n=3082007

A Phase I-II, Randomized, Controlled, Dose-Ranging Study of the Safety, Reactogenicity, and Immunogenicity of Intramuscular Inactivated Influenza A/H5N1 Vaccine Given Alone or With Aluminum Hydroxide to Healthy Elderly Adults

CompletedPH I/IINational Institute of Allergy and Infectious Diseases (NIAID)n=6002007

A Phase I-II, Randomized, Controlled, Dose-Ranging Study of the Safety, Reactogenicity, and Immunogenicity of Intramuscular Inactivated Influenza A/H5N1 Vaccine Given Alone or With Aluminum Hydroxide to Healthy Adults

CompletedPH I/IINational Institute of Allergy and Infectious Diseases (NIAID)n=6002006

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Major research themes1
Immunogenicity, Vaccine1
Journals, researchers & institutions
Top journals
  • JAMA1
Leading researchers
  • Chen W1
  • Du J1
  • Duan K1
  • Gao X1
  • Guo J1
  • Guo W1
  • Huang L1
  • Huang S1
Leading institutions
free-text, unnormalised
  • Chinese Academy of Sciences Key Laboratory of Special Pathogens1
  • College of Public Health1
  • Henan Center for Disease Control and Prevention1
  • Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubation)1
  • National Engineering Technology Research Center for Combined Vaccines1
  • National Medical Center for Major Public Health Events1

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

COVID-19 Vaccines

Studied across 3 of the same disease areas as Aluminum Hydroxide in the shared literature.

3 shared diseases1 shared paper
Propiolactone

Studied across 3 of the same disease areas as Aluminum Hydroxide in the shared literature.

3 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials