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Drug

Bismuth

In clinical development
Emerging researchLate-stage development

Also known as Bi - Bismuth.

RxNorm1599UNIIU015TT5I8H
2
Research papers
2
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Efficacy and Safety of Tegoprazan-Based Dual, Triple, and Quadruple Therapies as First-Line Regimens for Helicobacter Pylori Eradication: A Prospective Randomized Controlled Trial

Clinical trial2026-03-10Completed · ClinicalTrials.gov

Efficacy and Safety of Saccharomyces Boulardii Combined With Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Treatment: A Prospective, Multicenter, Randomized Controlled Trial

Clinical trial2025-12-02Results expected Q3 2026 · ClinicalTrials.gov

Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial

Clinical trial2025-10-01Primary completion · ClinicalTrials.gov

Study on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line Eradication

Clinical trial2025-06-25Completed · ClinicalTrials.gov

Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.

Clinical trial2024-11-01Primary completion · ClinicalTrials.gov

Rescue Therapy for Helicobacter Pylori Eradication: A Randomized and Non-inferiority Trail of Vonorazon and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy

Clinical trial2024-08-30Completed · ClinicalTrials.gov

Capacitive and Efficient Near-Infrared Stimulation of Neurons via an Ultrathin AgBiS<sub>2</sub> Nanocrystal Layer.

Research2024-05-29ACS applied materials & interfaces

Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology

Clinical trial2024-03-10Completed · ClinicalTrials.gov

An Open-label, Fixed-sequence Study to Evaluate the Drug-drug Interactions Between Tegoprazan Tablets and Bismuth Potassium Citrate Capsules, Amoxicillin Capsules, and Clarithromycin Tablets in Healthy Subjects

Clinical trial2023-04-28Completed · ClinicalTrials.gov

Study on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line Eradication

Clinical trial2022-06-30Completed · ClinicalTrials.gov

Efficacy and Safety of Berberine Hydrochloride, Amoxicillin and Rabeprazole Triple Therapy in the First Eradication of Helicobacter Pylori

Clinical trial2021-12-20Completed · ClinicalTrials.gov

Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report.

Research2016-10-05Gut

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Bismuth
Aliases & brands
Bi - Bismuth
RxNorm CUI
1599
UNII
U015TT5I8H

Clinical trials

24 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
24
registered trials across all phases
LATEST COMPLETION 2026
2
Active studies
2
Recruiting
21
Late-stage (III+)
19
Completed
3
Discontinued
PHASE DISTRIBUTIONn = 24
Phase 13Phase 416Phase N / A5

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Efficacy and Safety of Saccharomyces Boulardii Combined With Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Treatment: A Prospective, Multicenter, Randomized Controlled Trial

RecruitingPH IVKey trialYongquan Shin=1,2482026

Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial

RecruitingPH IVYongquan Shin=4002025

Study on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line Eradication

CompletedPH IVXijing Hospital of Digestive Diseasesn=5582025

Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.

Unknown statusPH IVXijing Hospital of Digestive Diseasesn=5482024

Rescue Therapy for Helicobacter Pylori Eradication: A Randomized and Non-inferiority Trail of Vonorazon and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy

CompletedPH IVYongquan Shin=6882024

Recent completions

Trials that read out recently, adding to the completed evidence base.

Efficacy and Safety of Tegoprazan-Based Dual, Triple, and Quadruple Therapies as First-Line Regimens for Helicobacter Pylori Eradication: A Prospective Randomized Controlled Trial

CompletedN/AZhongshan Hospital (Xiamen), Fudan Universityn=6402026

Study on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line Eradication

CompletedPH IVXijing Hospital of Digestive Diseasesn=5582025

Rescue Therapy for Helicobacter Pylori Eradication: A Randomized and Non-inferiority Trail of Vonorazon and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy

CompletedPH IVYongquan Shin=6882024

Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology

CompletedPH IVXijing Hospital of Digestive Diseasesn=1242024

An Open-label, Fixed-sequence Study to Evaluate the Drug-drug Interactions Between Tegoprazan Tablets and Bismuth Potassium Citrate Capsules, Amoxicillin Capsules, and Clarithromycin Tablets in Healthy Subjects

CompletedPH IShandong Luoxin Pharmaceutical Group Stock Co., Ltd.n=222023

Study on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line Eradication

CompletedPH IVXijing Hospital of Digestive Diseasesn=3002022

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20172024
Major research themes4
Bismuth1Helicobacter pylori1Neurons1Sulfides1
Journals, researchers & institutions
Top journals
  • ACS applied materials & interfaces1
  • Gut1
Leading researchers
  • Atherton J1
  • Axon AT1
  • Balamur R1
  • Bazzoli F1
  • El-Omar EM1
  • Gasbarrini A1
  • Gisbert JP1
  • Graham DY1
Leading institutions
free-text, unnormalised
  • Erasmus University Medical Center1
  • General Infirmary Leeds1
  • Henry Dunant Hospital1
  • Hospital Universitario de La Princesa1
  • ICFO-Institut de Ciencies Fotoniques1
  • Institut für Medizinische Mikrobiologie1

Related drugs

4 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Amoxicillin

Studied across 4 of the same disease areas as Bismuth in the shared literature.

4 shared diseases1 shared paper
Clarithromycin

Studied across 4 of the same disease areas as Bismuth in the shared literature.

4 shared diseases1 shared paper
Silver

Frequently co-studied with Bismuth in the research literature.

1 shared paper
Silver Compounds

Frequently co-studied with Bismuth in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials