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Drug

Calcitonin

Regulatory activity · MHRA
Emerging researchLate-stage development

Also known as CT - Calcitonin, Thyrocalcitonin.

RxNorm1311287
1
Research papers
3
Active clinical trials
1
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

The Prophylactic Value of Subcutaneous Calcitonin in Acute Herpes Zoster Patients: A Randomized Controlled Trial

Clinical trial2026-07-06Results expected Q2 2027 · ClinicalTrials.gov

Improving the Sensitivity of Sestamibi SPECT-CT Parathyroid Scan with Calcitonin Pre-treatment for Primary Hyperparathyroidism

Clinical trial2026-06-01Primary completion · ClinicalTrials.gov

Effect of Early Calcitonin Therapy on Incidence and Severity of Neuropathic Pain After Spinal Cord Injury

Clinical trial2026-05-14Results expected Q2 2027 · ClinicalTrials.gov

Assessing Quality of Life Changes Using Calcitonin in Patients With Hypothyroidism on Biochemical Replacement With Levothyroxine

Clinical trial2022-02-21Results posted · ClinicalTrials.gov

Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus

Clinical trial2018-02-12Results posted · ClinicalTrials.gov

The Pre-emptive Value of Epidural Calcitonin in Patients With Lower Limb Amputation. A Double Blinded Randomized Study

Clinical trial2016-08-01Completed · ClinicalTrials.gov

Evaluation of FGF-23 Suppressibility by Calcitonin in Healthy Men - Pilot Study

Clinical trial2016-06-28Completed · ClinicalTrials.gov

Drug Safety Update: Calcitonin (Miacalcic): increased risk of cancer with long-term use

Regulatory2014-12-11MHRA

A Randomized, Double-Blind, Multiple Dose, Placebo-Controlled, Parallel Group, 48-Week, Study of Oral Recombinant Salmon Calcitonin (rsCT) Compared to Salmon Calcitonin (sCT) Nasal Spray in Postmenopausal Osteoporotic Women

Clinical trial2013-11-19Results posted · ClinicalTrials.gov

A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) trial.

Research2012-08-01Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Phase II Study of Calcitonin for Tumoral Calcinosis

Clinical trial2005-06-24Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Calcitonin
Aliases & brands
CT - CalcitoninThyrocalcitonin
RxNorm CUI
1311287
Regulatory jurisdictions
mhra

Regulatory timeline

1 event

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Authorities
MHRA
Total events
1
mhraMedicines and Healthcare products Regulatory Agency· 1 event
2014-12-11Safety communicationSafety
Drug Safety Update: Calcitonin (Miacalcic): increased risk of cancer with long-term use
Evidence ↗

Contains public sector information from the Medicines and Healthcare products Regulatory Agency (MHRA) licensed under the Open Government Licence (OGL v3).

Clinical trials

9 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
9
registered trials across all phases
LATEST COMPLETION 2019
3
Active studies
3
Recruiting
8
Late-stage (III+)
6
Completed
PHASE DISTRIBUTIONn = 9
Phase 21Phase 32Phase 42Phase N / A4

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Improving the Sensitivity of Sestamibi SPECT-CT Parathyroid Scan with Calcitonin Pre-treatment for Primary Hyperparathyroidism

RecruitingPH IVJoseph Sferran=372026

Assessing Quality of Life Changes Using Calcitonin in Patients With Hypothyroidism on Biochemical Replacement With Levothyroxine

CompletedPH IVUniversity of Maryland, Baltimoren=112019

The Prophylactic Value of Subcutaneous Calcitonin in Acute Herpes Zoster Patients: A Randomized Controlled Trial

RecruitingPH IIITanta Universityn=1682027

A Randomized, Double-Blind, Multiple Dose, Placebo-Controlled, Parallel Group, 48-Week, Study of Oral Recombinant Salmon Calcitonin (rsCT) Compared to Salmon Calcitonin (sCT) Nasal Spray in Postmenopausal Osteoporotic Women

CompletedPH IIITarsa Therapeutics, Inc.n=5652011

Recent completions

Trials that read out recently, adding to the completed evidence base.

Assessing Quality of Life Changes Using Calcitonin in Patients With Hypothyroidism on Biochemical Replacement With Levothyroxine

CompletedPH IVUniversity of Maryland, Baltimoren=112019

The Pre-emptive Value of Epidural Calcitonin in Patients With Lower Limb Amputation. A Double Blinded Randomized Study

CompletedN/ATanta Universityn=602016

Evaluation of FGF-23 Suppressibility by Calcitonin in Healthy Men - Pilot Study

CompletedN/ARijnstate Hospitaln=492012

Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus

CompletedN/AUniversity of Colorado, Denvern=42012

A Randomized, Double-Blind, Multiple Dose, Placebo-Controlled, Parallel Group, 48-Week, Study of Oral Recombinant Salmon Calcitonin (rsCT) Compared to Salmon Calcitonin (sCT) Nasal Spray in Postmenopausal Osteoporotic Women

CompletedPH IIITarsa Therapeutics, Inc.n=5652011

Phase II Study of Calcitonin for Tumoral Calcinosis

CompletedPH IINational Center for Research Resources (NCRR)n=9

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) trial.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012 · 110 cites
Recent papers

A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) trial.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012 · 110 cites
Journals, researchers & institutions
Top journals
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1
Leading researchers
  • Binkley N1
  • Bolognese M1
  • Buben CE1
  • Gilligan JP1
  • Krause DS1
  • Miller C1
  • Sidorowicz-Bialynicka A1
  • Trout R1
Leading institutions
free-text, unnormalised
  • Osteoporosis Clinical Center and Research Program1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.