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Drug

Cannabidiol

Approved · FDA / EMA
ClassCannabinoid CB1 receptor negative allosteric modulatorEmerging researchLate-stage developmentRising momentum
Also known as (-)-trans-cannabidiol, .DELTA.1(2)-TRANS-CANNABIDIOL, CBD, CBD-A+4 more

(-)-trans-cannabidiol, .DELTA.1(2)-TRANS-CANNABIDIOL, CBD, CBD-A, Epidiolex, cannabidiol (CBD), (-)-trans-2-p-mentha-1,8-dien-3-yl-5-pentylresorcinol, (1'R,2'R)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydrobiphenyl-2,6-diol.

4
Research papers
55
Active clinical trials
Cannabinoid receptor 1
Primary target
18
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Evaluating the Impact of a Novel Cannabinoid Product for Endometriosis

Clinical trial2026-07-21Results expected Q4 2026 · ClinicalTrials.gov

Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving

Clinical trial2026-07-10Results expected Q4 2030 · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Cannabidiol
Aliases & brands
(-)-trans-cannabidiol.DELTA.1(2)-TRANS-CANNABIDIOLCBDCBD-AEpidiolexcannabidiol (CBD)(-)-trans-2-p-mentha-1,8-dien-3-yl-5-pentylresorcinol(1'R,2'R)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydrobiphenyl-2,6-diol
RxNorm CUI
2045371
ChEMBL ID
CHEMBL190461
ATC codes
N03AX24
UNII
19GBJ60SN5
Primary mechanism
Cannabinoid CB1 receptor negative allosteric modulator
Regulatory jurisdictions
emafda

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

NEGATIVE ALLOSTERIC MODULATORCannabinoid CB1 receptor negative allosteric modulator

Regulatory timeline

18 events

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Approval / market entry confirmed across FDA and EMA (2018-06-252019-09-19)
Earliest approval
2018-06-25
Latest approval
2023-10-20
Authorities
FDA · EMA
Total events
18
fdaU.S. Food and Drug Administration· 17 events
2026-06-05Label change
Label change: CANNABIDIOL (NDA210365)
Evidence ↗
2026-06-05Label change
Label change: CANNABIDIOL (NDA210365)
Evidence ↗
2026-06-05Label change
Label change: CANNABIDIOL (NDA210365)
Evidence ↗
emaEuropean Medicines Agency· 1 event
2019-09-19ApprovalMulti-authority
Approval: Epidyolex (EMA)
Indication: Epidyolex is indicated for use as adjunctive therapy of seizures associated with Lennox Gastaut syndrome (LGS) or Dravet syndrome (DS), in conjunction with clobazam, for patientsShow full indication

Epidyolex is indicated for use as adjunctive therapy of seizures associated with Lennox Gastaut syndrome (LGS) or Dravet syndrome (DS), in conjunction with clobazam, for patients 2 years of age and older.

Evidence ↗

Data from the U.S. Food and Drug Administration (U.S. Food and Drug Administration), public domain (CC0).

Contains information from the European Medicines Agency (European Medicines Agency), © EMA, reused under CC BY 4.0.

Clinical trials

181 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
181
registered trials across all phases
LATEST COMPLETION 2026
55
Active studies
49
Recruiting
41
Late-stage (III+)
74
Completed
52
Discontinued
PHASE DISTRIBUTIONn = 181
Early Phase 112Phase 132Phase 1 / 217Phase 279Phase 2 / 311Phase 312Phase 45Phase N / A13

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

4 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20222024
Major research themes8
Cannabidiol4Cannabinoids2Epilepsy2Mental Disorders2Alzheimer Disease1Cannabis1Medical Marijuana1Multiple Sclerosis1
Journals, researchers & institutions
Top journals
  • Basic & clinical pharmacology & toxicology1
  • Behavioural neurology1
  • Pharmacology1
  • Pharmacopsychiatry1
Leading researchers
  • Bhushan B1
  • Chanchal DK1
  • Coimbra NC1
  • Dammann I1
  • de Fátima Dos Santos Sampaio M1
  • de Paiva YB1
  • Kumar G1
  • Kumar S1
Leading institutions
free-text, unnormalised
  • Behavioural Neurosciences Institute (INeC)1
  • Brain and Mind Centre1
  • Center for Agropastoralism Sciences and Technology (CCTA)1
  • Central Institute of Mental Health1
  • Dr. Bhimrao Ambedkar University1
  • Glocal School of Pharmacy1

Related diseases

2 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Active research areas

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 4 of the same disease areas as Cannabidiol in the shared literature.

4 shared diseases2 shared papers
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.