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Drug

Captopril

In clinical development
ClassAngiotensin-converting enzyme inhibitorEmerging researchLate-stage development
Also known as CP, Capoten, Captopril-Hydrochlorothiazide, D-2-methyl-3-mercaptopropanoyl-L-proline+3 more

CP, Capoten, Captopril-Hydrochlorothiazide, D-2-methyl-3-mercaptopropanoyl-L-proline, D-3-mercapto-2-methylpropanoyl-L-proline, L-Captopril, Captoprilum.

RxNorm1998ChEMBLCHEMBL1560ATCC09AA01UNII9G64RSX1XD
2
Research papers
2
Active clinical trials
Angiotensin-converting enzyme
Primary target
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Pilot Randomized Clinical Trial to Assess Feasibility, Safety, and Efficacy of Rapid, Simultaneous Therapy Initiation in Chronic Kidney Disease and Type 2 Diabetes: RAPID-CKD

Clinical trial2026-05-08Results expected Q1 2029 · ClinicalTrials.gov

Application of Autologous Stem Cells From Adipose Tissue in the Regeneration of Knee Joint Cartilage

Clinical trial2026-02-12Results expected Q3 2026 · ClinicalTrials.gov

Effect of Virtual Reality and Classical Music Therapy on Blood Pressure and Anxiety in Patients With Hypertensive Urgency

Clinical trial2025-09-30Completed · ClinicalTrials.gov

Efficacy and Safety of Roselle in Patients With Grade 1 Essential Hypertension: A Phase III, Randomized, Double-Blind, Double-Dummy, Active-Controlled Clinical Trial

Clinical trial2025-04-01Primary completion · ClinicalTrials.gov

Phase I/II Prospective Trial Investigating the Safety and Efficacy of Captopril Use on the Degree of Marrow Fibrosis in Patients With Primary or Secondary Bone Marrow Fibrosis/Myeloproliferative Neoplasms

Clinical trial2024-10-01Withdrawn · ClinicalTrials.gov

Intermediate Term Effect of Captopril on Left Ventricle Global Longitudinal Strain in Patients With Duchenne Myodystrophy

Clinical trial2024-09-30Primary completion · ClinicalTrials.gov

An Open-label, Fixed-sequence, 3-period Crossover Exploratory Study to Investigate the Effect of Urine Acid-base Disequilibrium on the Pharmacokinetics of Captopril in Healthy Male Volunteers

Clinical trial2024-04-01Completed · ClinicalTrials.gov

Oxidative Stress in Children and Adolescents With Diabetic Nephropathy and the Role of Adjuvant Alpha-lipoic Acid as an Antioxidant

Clinical trial2024-01-31Primary completion · ClinicalTrials.gov

The Role of TGF-β in Abdominal Radiation Injury and Taking Medicine to Block TGF-β for Protecting Normal Organization

Clinical trial2022-06-25Primary completion · ClinicalTrials.gov

An Open-label, Randomized Three Period, Three Sequence, Partially Replicated Crossover Bioequivalence Study of Two Oral Formulations of Captopril 50 mg Film Coated Tablets in Healthy Adult Participants Under Fasting Conditions

Clinical trial2022-03-25Withdrawn · ClinicalTrials.gov

Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction.

Research2004-09-01The New England journal of medicine

Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both.

Research2003-11-10The New England journal of medicine

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Captopril
Aliases & brands
CPCapotenCaptopril-HydrochlorothiazideD-2-methyl-3-mercaptopropanoyl-L-prolineD-3-mercapto-2-methylpropanoyl-L-prolineL-CaptoprilCaptoprilum
RxNorm CUI
1998
ChEMBL ID
CHEMBL1560
ATC codes
C09AA01
UNII
9G64RSX1XD
Primary mechanism
Angiotensin-converting enzyme inhibitor

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Angiotensin-converting enzyme
ACE · P12821
INHIBITORAngiotensin-converting enzyme inhibitor

Clinical trials

28 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
28
registered trials across all phases
LATEST COMPLETION 2025
2
Active studies
1
Recruiting
14
Late-stage (III+)
12
Completed
14
Discontinued
PHASE DISTRIBUTIONn = 28
Early Phase 11Phase 15Phase 1 / 24Phase 24Phase 2 / 31Phase 33Phase 48Phase N / A2

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

A Pilot Randomized Clinical Trial to Assess Feasibility, Safety, and Efficacy of Rapid, Simultaneous Therapy Initiation in Chronic Kidney Disease and Type 2 Diabetes: RAPID-CKD

Not yet recruitingPH IVBaylor Research Instituten=642029

Application of Autologous Stem Cells From Adipose Tissue in the Regeneration of Knee Joint Cartilage

Active, not recruitingPH IVClinical Center of Vojvodinan=602027

Evaluation of the Efficacy of Captopril Versus Propranolol and Timolol as a Treatment of Infantile Capillary Hemangioma

Unknown statusPH IVAin Shams Universityn=1002021

Comparative Effecacy of Metformin and Vildagliptin on Cardiometabolic Risk Factors, Metabolic Syndrome, and Diabetic Nephropathy Progression

Unknown statusPH IVCairo Universityn=392020

Randomized Clinical Trial for Effectiveness of Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure

CompletedPH IVInstituto Materno Infantil Prof. Fernando Figueiran=902013

Recent completions

Trials that read out recently, adding to the completed evidence base.

Effect of Virtual Reality and Classical Music Therapy on Blood Pressure and Anxiety in Patients With Hypertensive Urgency

CompletedN/AAnkara City Hospital Bilkentn=1302025

An Open-label, Fixed-sequence, 3-period Crossover Exploratory Study to Investigate the Effect of Urine Acid-base Disequilibrium on the Pharmacokinetics of Captopril in Healthy Male Volunteers

CompletedPH ISeoul National University Hospitaln=122024

A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma

CompletedPH I/IIUniversity of Ulmn=102020

Prediction and Prevention of Asymptomatic Cardiovascular Insult in Type 1 Diabetic Children: Comparative Effectiveness of Cardio-protective Drugs

CompletedN/ATanta Universityn=1502019

The Pathophysiology and Treatment of Supine Hypertension in Patients With Autonomic Failure

CompletedPH IVanderbilt Universityn=1522017

Randomized Clinical Trial for Effectiveness of Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure

CompletedPH IVInstituto Materno Infantil Prof. Fernando Figueiran=902013

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20032004
Major research themes2
Angiotensin II Type 1 Receptor Blockers1Angiotensin Receptor Antagonists1
Journals, researchers & institutions
Top journals
  • The New England journal of medicine2
Leading researchers
  • Califf RM2
  • Leimberger JD2
  • McMurray JJ2
  • Pfeffer MA2
  • Rouleau JL2
  • Solomon SD2
  • Velazquez EJ2
  • Zelenkofske S2
Leading institutions
free-text, unnormalised
  • Brigham and Women's Hospital2

Related diseases

2 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Valine

Studied across 6 of the same disease areas as Captopril in the shared literature.

6 shared diseases2 shared papers
Valsartan

Studied across 6 of the same disease areas as Captopril in the shared literature.

6 shared diseases2 shared papers
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials