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Drug

Ceftriaxone

Regulatory activity · MHRA
Emerging researchLate-stage development

Also known as Rocephin, Ceftriaxona, CefTRIAXone Sodium, Ceftriaxonum.

RxNorm2193ChEMBLCHEMBL161UNII75J73V1629
1
Research papers
9
Active clinical trials
1
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Phase 1/2, Randomized, Double-Blind, Placebo-Controlled Trial of Pulse Dosed Ceftriaxone for Post-Treatment Lyme Disease

Clinical trial2026-05-14Withdrawn · ClinicalTrials.gov

Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery: A Double Blinded Randomized Controlled Trial

Clinical trial2026-05-01Results expected Q4 2026 · ClinicalTrials.gov

Comparison of Intravenous Ciprofloxacin and Intravenous Ceftriaxone in the Management of Spontaneous Bacterial Peritonitis in Cirrhosis of Liver

Clinical trial2026-04-14Completed · ClinicalTrials.gov

Phase 1, Randomized, Double-Blind, Placebo-Controlled Trial of Pulse Dosed Ceftriaxone for Post-Treatment Lyme Disease

Clinical trial2026-03-19Results expected Q4 2026 · ClinicalTrials.gov

Division of Microbiology and Infectious Diseases, (DMID) 21-0018: Efficacy of Immunization With 4C-MenB in Preventing Experimental Urethral Infection With Neisseria Gonorrhoeae

Clinical trial2026-02-05Completed · ClinicalTrials.gov

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Clinical trial2026-02-01Primary completion · ClinicalTrials.gov

Improvement of PPROM Management With Prophylactic Antimicrobial Therapy

Clinical trial2026-01-27Results expected Q4 2026 · ClinicalTrials.gov

Comparison of Enhanced Molecular-Level Microbiological Surveillance and Ceftriaxone Prophylaxis in Patients Undergoing Hematopoietic Cell Transplantation: A Randomized, Prospective Medical Experiment

Clinical trial2025-12-29Results expected Q2 2027 · ClinicalTrials.gov

Clearance of Asymptomatic Pharyngeal Carriage of Neisseria Gonorrhoeae With or Without Ceftriaxone Treatment: Randomized Non-inferiority Study

Clinical trial2025-12-01Primary completion · ClinicalTrials.gov

Assessing the Longitudinal Outcomes of Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA): a Randomized Controlled Trial

Clinical trial2025-10-20Completed · ClinicalTrials.gov

Drug Safety Update: Ceftriaxone (rocephin): incompatible with solutions containing calcium

Regulatory2014-12-11MHRA

Safety and pharmacokinetics of subcutaneous ceftriaxone administered with or without recombinant human hyaluronidase (rHuPH20) versus intravenous ceftriaxone administration in adult volunteers.

Research2010-02-01Current medical research and opinion

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Ceftriaxone
Aliases & brands
RocephinCeftriaxonaCefTRIAXone SodiumCeftriaxonum
RxNorm CUI
2193
ChEMBL ID
CHEMBL161
UNII
75J73V1629
Regulatory jurisdictions
mhra

Regulatory timeline

1 event

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Authorities
MHRA
Total events
1
mhraMedicines and Healthcare products Regulatory Agency· 1 event
2014-12-11Safety communicationSafety
Drug Safety Update: Ceftriaxone (rocephin): incompatible with solutions containing calcium
Evidence ↗

Contains public sector information from the Medicines and Healthcare products Regulatory Agency (MHRA) licensed under the Open Government Licence (OGL v3).

Clinical trials

98 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
98
registered trials across all phases
LATEST COMPLETION 2026
9
Active studies
8
Recruiting
73
Late-stage (III+)
58
Completed
31
Discontinued
PHASE DISTRIBUTIONn = 98
Early Phase 11Phase 14Phase 1 / 23Phase 217Phase 2 / 35Phase 326Phase 428Phase N / A14

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Screen-and-treat Strategy for Vaginal Flora Abnormalities by Multiplex Molecular Biology Using POC Technology in Pregnant Women at High Risk of Preterm Birth: A Multicentre, Randomized Study (AUTOP2)

Not yet recruitingPH IVKey trialAssistance Publique Hopitaux De Marseillen=1,2922028

Improvement of PPROM Management With Prophylactic Antimicrobial Therapy

RecruitingPH IVOhio State Universityn=562026

Treatment Responses of Early Syphilis to Single-dose Ceftriaxone Plus Doxycycline Versus Single-dose Benzathine Penicillin G Plus Doxycycline in People Living With HIV (PLWH)

TerminatedPH IVNational Taiwan University Hospitaln=1092025

The Effect of the Combination of Mecobalamin and Ceftriaxone Sodium on Liver Injury in Sepsis and Clinical Prognosis Observation

Unknown statusPH IVSichuan Provincial People's Hospitaln=402025

Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis: a Prospective Randomized Placebo-controlled Double-blind Multicenter Trial

TerminatedPH IVUniversity Hospital, Lillen=1032024

Recent completions

Trials that read out recently, adding to the completed evidence base.

Comparison of Intravenous Ciprofloxacin and Intravenous Ceftriaxone in the Management of Spontaneous Bacterial Peritonitis in Cirrhosis of Liver

CompletedN/AShahida Islam Medical Complexn=3102026

Division of Microbiology and Infectious Diseases, (DMID) 21-0018: Efficacy of Immunization With 4C-MenB in Preventing Experimental Urethral Infection With Neisseria Gonorrhoeae

CompletedPH IIUniversity of North Carolina, Chapel Hilln=652026

Assessing the Longitudinal Outcomes of Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA): a Randomized Controlled Trial

CompletedPH IIMcMaster Children's Hospitaln=162025

Comparison Between Effect of Empirical Antibiotic Prophylaxis Versus Enhanced Prophylactic Measures on Rate of Urinary Tract Infection After Flexible Ureteroscopy in Children With Pyuria

CompletedPH II/IIIAin Shams Universityn=1402025

Supportive Care and Antibiotics for Severe Pneumonia Among Hospitalized Children (SEARCH): A Pragmatic Randomised Controlled Trial

CompletedPH IIIKey trialUniversity of Oxfordn=4,3922024

Antibiotic Instillation in Acute Complex Appendicitis for Prevention of Deep Space Surgical Site Infections

CompletedPH IIJohns Hopkins All Children's Hospitaln=1902024

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Journals, researchers & institutions
Top journals
  • Current medical research and opinion1
Leading researchers
  • Battikha J1
  • Harb G1
  • Lebel F1
  • Thackara JW1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.