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Drug

Citric Acid

In clinical development
Emerging researchLate-stage development
Also known as 2-Hydroxytricarballylic acid, Acidum citricum, Alka-Seltzer, Bicitra+28 more

2-Hydroxytricarballylic acid, Acidum citricum, Alka-Seltzer, Bicitra, Bromo Seltzer Antacid Pain Reliever, Citronensäure, Clenpiq, Cytra 2, Cytra-2, Cytra-3, Cytra-K, E-Z-Gas II, K+Care ET, Liqui-Dualcitra, Oracit, Phexx, Phexxi, Picot, Polycitra, Polycitra-K, Polycitra-LC, Prepopik, Renacidin, Urologic G, ácido cítrico, 2-hydroxy-1,2,3-propanetricarboxyic acid, 3-carboxy-3-hydroxypentane-1,5-dioic acid, Citric Acid-Potassium Citrate, Citric Acid-Sodium Citrate, Potassium Citrate-Citric Acid, Potassium Citrate-Sodium Citrate-Citric Acid, Sodium Citrate Dihydrate.

RxNorm21183ChEMBLCHEMBL2107737UNII2968PHW8QP
2
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Leaching mechanism and behavior of rare earth elements from roasted coal gangue using citric acid

Industry2026-07-31Nature — Environmental Sciences

Citric Acid: Properties, Microbial Production, and Applications in Industries.

Research2023-12-19Molecules (Basel, Switzerland)

A Cross-sectional Study to Measure Cough in Severe Asthma

Clinical trial2023-11-22Results posted · ClinicalTrials.gov

Effect of Low Level Laser Therapy on Prevention of Radiotherapy Induced Xerostomia in Cancer Patients.

Clinical trial2020-11-01Primary completion · ClinicalTrials.gov

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.

Research2020-02-04Nature communications

The Effect of Citric Acid as the Test Meal on the Diagnostic Accuracy of the 13C-Urea Breath Test in Korean, Randomized Controlled, Open Label Prospective Study

Clinical trial2018-12-31Completed · ClinicalTrials.gov

The Influence of Citric Acid Bone Surface Etching and Bone Substitute Intra-osseous Defect Fill on Crevicular Fluid BMP-2 Release Profile (Randomized Clinical Trial)

Clinical trial2018-11-01Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Citric Acid
Aliases & brands
2-Hydroxytricarballylic acidAcidum citricumAlka-SeltzerBicitraBromo Seltzer Antacid Pain RelieverCitronensäureClenpiqCytra 2Cytra-2Cytra-3Cytra-KE-Z-Gas IIK+Care ETLiqui-DualcitraOracitPhexxPhexxiPicotPolycitraPolycitra-KPolycitra-LCPrepopikRenacidinUrologic Gácido cítrico2-hydroxy-1,2,3-propanetricarboxyic acid3-carboxy-3-hydroxypentane-1,5-dioic acidCitric Acid-Potassium CitrateCitric Acid-Sodium CitratePotassium Citrate-Citric AcidPotassium Citrate-Sodium Citrate-Citric AcidSodium Citrate Dihydrate
RxNorm CUI
21183
ChEMBL ID
CHEMBL2107737
UNII
2968PHW8QP

Clinical trials

4 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
4
registered trials across all phases
LATEST COMPLETION 2019
4
Late-stage (III+)
3
Completed
1
Discontinued
PHASE DISTRIBUTIONn = 4
Phase 41Phase N / A3

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

The Influence of Citric Acid Bone Surface Etching and Bone Substitute Intra-osseous Defect Fill on Crevicular Fluid BMP-2 Release Profile (Randomized Clinical Trial)

CompletedPH IVAin Shams Universityn=202018

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20202023
Major research themes2
Aspergillus niger1Citric Acid1
Journals, researchers & institutions
Top journals
  • Molecules (Basel, Switzerland)1
  • Nature communications1
Leading researchers
  • Baseler WA1
  • Cassel T1
  • Davies LC1
  • Fan TW1
  • Ghesquière B1
  • Gonzalez-Cotto M1
  • Higashi RM1
  • Książek E1
Leading institutions
free-text, unnormalised
  • Department of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry1
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development1
  • Metabolomics Expertise Center1
  • National Cancer Institute1
  • School of Cellular and Molecular Medicine1
  • School of Medicine1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Nitric Oxide

Studied across the same disease area as Citric Acid in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials