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Drug

Clobetasol

In clinical development
Emerging researchLate-stage development
Also known as Byqlovi, Clobetasol 17 Propionate, Clobetasol Propionate, Clobevate+9 more

Byqlovi, Clobetasol 17 Propionate, Clobetasol Propionate, Clobevate, Clobex, Clodan, Cormax, Embeline, Impeklo, Impoyz, Olux, Temovate, Tovet.

RxNorm2590ChEMBLCHEMBL1201362UNIIADN79D536H
1
Research papers
4
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Phase 2, Open-Label, Randomized Trial Evaluating the Impact of Enhanced Versus Standard Dermatologic Management on Selected Dermatologic Adverse Events Among Patients With Locally Advanced or Metastatic EGFR-Mutated NSCLC Treated First-Line With Amivantamab + Lazertinib

Clinical trial2026-07-06Results expected Q2 2027 · ClinicalTrials.gov

Influence of Dermocorticoids on Bone Mineral Density in Patients With Bullous Pemphigoid

Clinical trial2026-03-04Completed · ClinicalTrials.gov

A Phase 3, Multicenter, Randomized, Evaluator-blinded Clinical Trial to Assess the Safety and Efficacy of Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% Compared to Prednisolone Acetate, 1% in the Treatment of Inflammation After Cataract Surgery in Pediatric Population 0 to 3 Years of Age (CLOSE-3)

Clinical trial2025-12-31Primary completion · ClinicalTrials.gov

Early Intervention in Plaque Psoriasis: is Bimekizumab Able to Delay Chronic Inflammation? Prospective Multicenter Interventional Study

Clinical trial2025-11-25Results expected Q3 2028 · ClinicalTrials.gov

Regorafenib Dose Optimization Study (ReDOS): A Phase II Randomized Study of Lower Dose Regorafenib Compared to Standard Dose Regorafenib in Patients With Refractory Metastatic Colorectal Cancer (mCRC)

Clinical trial2025-06-18Results posted · ClinicalTrials.gov

A Comparison of Photodynamic Therapy and Topical Clobetasol in Treatment of Oral Lichen Planus: a Split-Mouth Randomised Controlled Study

Clinical trial2024-10-01Completed · ClinicalTrials.gov

Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus. A Multicenter Placebo-controlled Randomized Clinical Trial.

Clinical trial2024-07-03Primary completion · ClinicalTrials.gov

Randomized Clinical Trial, Controlled to Conventional Treatment, to Evaluate the Efficacy of Plasma Rich in Growth Factors (PRGF) for the Treatment of Lichen Sclerosus Atrophicus of the Vulva

Clinical trial2024-02-15Withdrawn · ClinicalTrials.gov

Evaluation of Topical Rebamipide Versus Topical Clobetasol in Management of Methotrexate-Induced Oral Ulceration in Rheumatoid Arthritis Patients: Randomized-Controlled Clinical Trial

Clinical trial2023-12-30Primary completion · ClinicalTrials.gov

A Phase 3, Multicenter, Randomized, Double-Masked Clinical Trial to Assess the Efficacy and Safety of Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% Compared to Placebo in the Treatment of Inflammation and Pain Associated With Cataract Surgery

Clinical trial2022-12-22Results posted · ClinicalTrials.gov

A Phase 3, Multicenter, Randomized, Double-Masked Clinical Trial to Assess the Efficacy and Safety of Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% Compared to Placebo in the Treatment of Inflammation and Pain Associated With Cataract Surgery

Clinical trial2022-12-22Results posted · ClinicalTrials.gov

Dermatitis Herpetiformis: Novel Perspectives.

Research2019-06-11Frontiers in immunology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Clobetasol
Aliases & brands
ByqloviClobetasol 17 PropionateClobetasol PropionateClobevateClobexClodanCormaxEmbelineImpekloImpoyzOluxTemovateTovet
RxNorm CUI
2590
ChEMBL ID
CHEMBL1201362
UNII
ADN79D536H

Clinical trials

26 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
26
registered trials across all phases
LATEST COMPLETION 2026
4
Active studies
2
Recruiting
16
Late-stage (III+)
14
Completed
8
Discontinued
PHASE DISTRIBUTIONn = 26
Phase 14Phase 26Phase 2 / 32Phase 37Phase 44Phase N / A3

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Influence of Dermocorticoids on Bone Mineral Density in Patients With Bullous Pemphigoid

CompletedPH IVCentre Hospitalier Universitaire, Amiensn=472026

Combined Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata A Randomized Controlled Trial

CompletedPH IVCairo Universityn=402017

An Open Label Study to Evaluate Safety, Efficacy and Tolerability of Clobetasol Propionate for the Condition of Chronic Hand Dermatitis

CompletedPH IVStiefel, a GSK Companyn=302009

Comparison of Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Experimentally Induced Skin Irritation

Unknown statusPH IVOdense University Hospitaln=362008

A Phase 3, Multicenter, Randomized, Evaluator-blinded Clinical Trial to Assess the Safety and Efficacy of Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% Compared to Prednisolone Acetate, 1% in the Treatment of Inflammation After Cataract Surgery in Pediatric Population 0 to 3 Years of Age (CLOSE-3)

RecruitingPH IIISalvatn=602025

Recent completions

Trials that read out recently, adding to the completed evidence base.

Influence of Dermocorticoids on Bone Mineral Density in Patients With Bullous Pemphigoid

CompletedPH IVCentre Hospitalier Universitaire, Amiensn=472026

A Comparison of Photodynamic Therapy and Topical Clobetasol in Treatment of Oral Lichen Planus: a Split-Mouth Randomised Controlled Study

CompletedPH IIWroclaw Medical Universityn=292024

Regorafenib Dose Optimization Study (ReDOS): A Phase II Randomized Study of Lower Dose Regorafenib Compared to Standard Dose Regorafenib in Patients With Refractory Metastatic Colorectal Cancer (mCRC)

CompletedPH IIAcademic and Community Cancer Research Unitedn=1232023

A Phase 3, Multicenter, Randomized, Double-Masked Clinical Trial to Assess the Efficacy and Safety of Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% Compared to Placebo in the Treatment of Inflammation and Pain Associated With Cataract Surgery

CompletedPH IIISalvatn=2502021

A Phase 3, Multicenter, Randomized, Double-Masked Clinical Trial to Assess the Efficacy and Safety of Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% Compared to Placebo in the Treatment of Inflammation and Pain Associated With Cataract Surgery

CompletedPH IIISalvatn=2152021

A Randomized, Double-blind, Placebo-controlled, Parallel Group Clinical Study to Assess the Safety and Efficacy of Three Doses of Clobetasol Propionate When Administered Intra-orally Twice Daily in Patients With Oral Lichen Planus (OLP) Using Rivelin®-CLO Patches

CompletedPH IIDermtreatn=1402019

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Dermatitis Herpetiformis: Novel Perspectives.

Frontiers in immunology · 2019 · 51 cites
Recent papers

Dermatitis Herpetiformis: Novel Perspectives.

Frontiers in immunology · 2019 · 51 cites
Major research themes2
Dermatitis Herpetiformis1Diet, Gluten-Free1
Journals, researchers & institutions
Top journals
  • Frontiers in immunology1
Leading researchers
  • Antiga E1
  • Bonciani D1
  • Bonciolini V1
  • Caproni M1
  • Maglie R1
  • Quintarelli L1
  • Verdelli A1
Leading institutions
free-text, unnormalised
  • University of Florence1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Dapsone

Studied across 2 of the same disease areas as Clobetasol in the shared literature.

2 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials