Drug

Clonidine

Established medicine

ClassAdrenergic receptor alpha-2 agonistResearchOngoing clinical research

Also known as Catapres, Chlorthalidone-Clonidine, Clorpres, Combipres+12 more

Catapres, Chlorthalidone-Clonidine, Clorpres, Combipres, Duraclon, Javadin, Kapvay, Nexiclon, Onyda, Clonidin, Clonidina, 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine, 2-((2,6-Dichlorophenyl)imino)imidazolidine, CloNIDine HCl, CloNIDine Hydrochloride, Clonidinum.

RxNorm2599 ChEMBLCHEMBL134 ATCC02AC01 ATCN02CX02 ATCS01EA04UNIIMN3L5RMN02

Active clinical trials

Protein targets

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Treating Nightmares in Posttraumatic Stress Disorder With the α-adrenergic Agents Clonidine and Doxazosin: A Randomized-Controlled Feasibility Study (ClonDoTrial)

Clinical trial2026-07-31Suspended · ClinicalTrials.gov

Efficacy of Ropivacaine Epinephrine Clonidine Ketorolac (R.E.C.K) vs Exparel in Robotic Nephrectomy: a Randomized, Prospective Trial

Clinical trial2026-07-13Results expected Q4 2027 · ClinicalTrials.gov

Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study

Clinical trial2026-07-02Results expected Q1 2028 · ClinicalTrials.gov

Efficacy of Clonidine in Reducing Craving in Inpatients With Cocaine and Crack Use Disorder: a Randomized Clinical Trial.

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery.

Clinical trial2026-06-01Primary completion · ClinicalTrials.gov

Clonidine to Prevent Postictal Delirium After ElectroConvulsive Therapy: a Randomised, Placebo-controlled, Triple-blind, Single-centre Trial.

Clinical trial2026-05-16Completed · ClinicalTrials.gov

Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery

Clinical trial2026-05-05Results expected Q2 2028 · ClinicalTrials.gov

The Effect of Local Anesthetic and Clonidine on the Cutaneous Silent Period During and After Spinal Anesthesia

Clinical trial2026-05-04Results expected Q3 2027 · ClinicalTrials.gov

A Phase II Randomized Study of Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients Receiving Adjuvant Hormonal Therapy

Clinical trial2026-03-05Results expected Q3 2027 · ClinicalTrials.gov

The PREVENT AGITATION Trial II - Children ≤1 Year

Clinical trial2026-01-31Primary completion · ClinicalTrials.gov

Treatment of Orthostatic Intolerance

Clinical trial2025-10-08Results expected Q4 2029 · ClinicalTrials.gov

Efficacy of Intrathecal Clonidine Versus Neostigmine as Adjuvants to Bupivacaine on Postoperative Maternal and Fetal Outcomes After Elective Cesarean Section: A Randomized Double Blind Controlled Trial

Clinical trial2025-09-30Primary completion · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Clonidine

Aliases & brands

CatapresChlorthalidone-ClonidineClorpresCombipresDuraclonJavadinKapvayNexiclonOnydaClonidinClonidina2,6-Dichloro-N-2-imidazolidinylidenebenzenamine2-((2,6-Dichlorophenyl)imino)imidazolidineCloNIDine HClCloNIDine HydrochlorideClonidinum

RxNorm CUI

2599

ChEMBL ID

CHEMBL134

ATC codes

C02AC01N02CX02S01EA04

UNII

MN3L5RMN02

Primary mechanism

Adrenergic receptor alpha-2 agonist