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Drug

Copper

In clinical development
Emerging researchLate-stage developmentSteady momentum
Also known as CI 77400, Cu - copper, Kupfer, Miudella+4 more

CI 77400, Cu - copper, Kupfer, Miudella, ParaGard, cobre, cuivre, cuprum.

15
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer.

Research2025-05-09Signal transduction and targeted therapy

Common and Trace Metals in Alzheimer's and Parkinson's Diseases.

Research2023-10-29International journal of molecular sciences

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Copper
Aliases & brands
CI 77400Cu - copperKupferMiudellaParaGardcobrecuivrecuprum
RxNorm CUI
2837
ChEMBL ID
CHEMBL55643
UNII
789U1901C5

Clinical trials

5 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
5
registered trials across all phases
LATEST COMPLETION 2024
1
Active studies
1
Recruiting
2
Late-stage (III+)
2
Completed
2
Discontinued
PHASE DISTRIBUTIONn = 5
Phase 11Phase 22Phase 2 / 31Phase 31

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Research activity

15 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20192025
Most influential

Copper homeostasis and cuproptosis in health and disease.

Signal transduction and targeted therapy · 2022 · 907 cites

Cuproptosis: mechanisms and links with cancers.

Molecular cancer · 2023 · 510 cites

Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy.

Journal of experimental & clinical cancer research : CR · 2022 · 235 cites

The essential elements of Alzheimer's disease.

The Journal of biological chemistry · 2021 · 211 cites
Recent papers
Major research themes8
Neoplasms8Copper6Apoptosis2Hepatolenticular Degeneration2Neurodegenerative Diseases2Trace Elements2Alzheimer Disease1Autoimmunity1
Journals, researchers & institutions
Top journals
  • International journal of molecular sciences3
  • Journal of hematology & oncology2
  • Signal transduction and targeted therapy2
  • Archives of toxicology1
  • Autophagy1
  • Journal of experimental & clinical cancer research : CR1
Leading researchers
  • Chen X2
  • Liu J2
  • Zhang Z2
  • Zhao H2
  • Alhazza IM1
  • Alwasel SH1
  • Ayton S1
  • Baj J1
Leading institutions
free-text, unnormalised
  • Baylor College of Medicine1
  • Beijing Tiantan Hospital1
  • Cancer Center1
  • Cancer Center and Laboratory of Molecular Targeted Therapy in Oncology1
  • Cardinal Stefan Wyszynski University1
  • Central Laboratory & Shenzhen Key Laboratory of Epigenetics and Precision Medicine for Cancers1

Related diseases

4 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

5 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 3 of the same disease areas as Copper in the shared literature.

3 shared diseases2 shared papers

Studied across the same disease area as Copper in the shared literature.

1 shared disease1 shared paper

Studied across the same disease area as Copper in the shared literature.

1 shared disease1 shared paper

Studied across the same disease area as Copper in the shared literature.

1 shared disease1 shared paper

Frequently co-studied with Copper in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials