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Drug

Cyclosporine

In clinical development
Emerging researchLate-stage developmentRising momentum
Also known as Atopica, Cequa, Ciclosporin, Ciclosporin A+21 more

Atopica, Cequa, Ciclosporin, Ciclosporin A, Ciclosporina, Ciclosporine, Ciclosporinum, CsA, CyA, Cyclavance, CycloSPORINE Modified, CycloSPORINE Opthalmic, Gengraf, Modulis, Neoral, Optimmune, Restasis, SandIMMUNE, Sangcya, Sporimune, Verkazia, Vevye, CycloSPORINE A, Cyclosporin, Cyclosporin A.

RxNorm3008ChEMBLCHEMBL160UNII83HN0GTJ6D
3
Research papers
19
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

Clinical trial2026-07-02Results expected Q4 2027 · ClinicalTrials.gov

rhTPO + CsA Versus CsA Alone in the Treatment of Lower-risk MDS With Thrombocytopenia: a Single-center Randomized Controlled Trial

Clinical trial2026-06-17Results expected Q4 2028 · ClinicalTrials.gov

Efficacy of Vevye Ophthalmic Solution for the Treatment of Meibomian Gland Dysfunction

Clinical trial2026-06-09Results expected Q1 2027 · ClinicalTrials.gov

Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A

Clinical trial2026-06-05Results expected Q3 2027 · ClinicalTrials.gov

A Phase II Trial of Allogeneic Peripheral Blood Stem Cell Transplantation From Matched Unrelated Donors in Patients With Advanced Hematologic Malignancies and Hematological Disorders

Clinical trial2026-06-02Results posted · ClinicalTrials.gov

A Phase III Randomized Trial Comparing Unrelated Donor Bone Marrow Transplantation With Immune Suppressive Therapy for Newly Diagnosed Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)

Clinical trial2026-05-19Results expected Q4 2029 · ClinicalTrials.gov

Cord Blood Transplantation in Children and Young Adults With Hematologic Malignancies

Clinical trial2026-05-14Results expected Q2 2030 · ClinicalTrials.gov

Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Precision Medicine Part 3 - Option II

Clinical trial2026-05-12Results expected Q4 2026 · ClinicalTrials.gov

A Multi-centre Phase II Trial of GVHD Prophylaxis Following Unrelated Donor Stem Cell Transplantation Comparing Thymoglobulin vs. Calcineurin Inhibitor or Sirolimus-based Post-transplant Cyclophosphamide

Clinical trial2026-05-05Results expected Q3 2027 · ClinicalTrials.gov

A Clinical Phase II Study to Assess Efficacy, Safety, and Tolerability of Waterfree Cyclosporine Formulation for Treatment of Dry Eye Disease.

Research2019-01-28Ophthalmology

Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis.

Research2012-06-12PLoS neglected tropical diseases

TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors.

Research2009-05-07Blood

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Cyclosporine
Aliases & brands
AtopicaCequaCiclosporinCiclosporin ACiclosporinaCiclosporineCiclosporinumCsACyACyclavanceCycloSPORINE ModifiedCycloSPORINE OpthalmicGengrafModulisNeoralOptimmuneRestasisSandIMMUNESangcyaSporimuneVerkaziaVevyeCycloSPORINE ACyclosporinCyclosporin A
RxNorm CUI
3008
ChEMBL ID
CHEMBL160
UNII
83HN0GTJ6D

Clinical trials

194 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
194
registered trials across all phases
LATEST COMPLETION 2025
19
Active studies
15
Recruiting
77
Late-stage (III+)
127
Completed
48
Discontinued
PHASE DISTRIBUTIONn = 194
Early Phase 11Phase 120Phase 1 / 216Phase 280Phase 2 / 36Phase 329Phase 425Phase N / A17

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Efficacy of Vevye Ophthalmic Solution for the Treatment of Meibomian Gland Dysfunction

RecruitingPH IVUniversity of Alabama at Birminghamn=482027

Combination Therapy of Vevye and Flarex for Dry Eye Disease

Enrolling by invitationPH IVCanyon City Eyecaren=602026

Efficacy and Safety of rhTPO in Combination With Cyclosporine Versus Cyclosporine Alone in the Treatment of Transfusion-dependent Non-severe Aplastic Anaemia (TD-NSAA)

Not yet recruitingPH IVPeking Union Medical College Hospitaln=542025

Romiplostim in Combination With Ciclosporin Versus Ciclosporin in the Treatment of Newly Diagnosed Non-severe Aplastic Anemia

Unknown statusPH IVPeking Union Medical College Hospitaln=442025

Effect of Obesity on Cyclosporine Blood Trough Level in Nephrotic Syndrome Patients

Unknown statusPH IVAlexandria Universityn=742024

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Comparative Study on the Efficacy of The Combined Use of Cyclosporine and Metformin in the Treatment of Psoriasis vs Cyclosporine Alone

CompletedPH ICairo Universityn=322025

A Randomized, Case Controlled Clinical Trial Evaluating the Efficiency and Safety of Luspatercept Plus Cyclosporine Versus Cyclosporine in Newly Diagnosed Transfusion Independent Non-severe Aplastic Anemia (NSAA).

CompletedPH IIBing Hann=582025

Hematopoietic Cell Transplantation in the Treatment of Infant Leukemia and Myelodysplastic Syndrome

CompletedPH IIMasonic Cancer Center, University of Minnesotan=342025

A Phase 1, Open-Label, Fixed-Sequence Study to Evaluate the Effect of Itraconazole and Cyclosporine on the Single-Dose Pharmacokinetics of Danuglipron in Healthy Adult Participants

CompletedPH IPfizern=162025

Transplantation of Umbilical Cord Blood for Patients With Hematological Diseases With Cyclophosphamide/Fludarabine/Total Body Irradiation or Cyclophosphamide/Fludarabine/Thiotepa/Total Body Irradiation Myeloablative Preparative Regimen

CompletedPH IIFred Hutchinson Cancer Centern=1352024

Dupilumab and House Dust Mite Immunotherapy in Patients With Atopic Dermatitis

CompletedN/AMedical University of Silesian=1322024

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20092019
Major research themes3
Hematopoietic Stem Cell Transplantation1Living Donors1Lymphatic Irradiation1
Journals, researchers & institutions
Top journals
  • Blood1
  • Ophthalmology1
  • PLoS neglected tropical diseases1
Leading researchers
  • Adonis A1
  • Arai S1
  • Babiker AG1
  • Bangham CR1
  • Beckert M1
  • Blume KG1
  • Brodnicki L1
  • Castro H1
Leading institutions
free-text, unnormalised
  • Centre for Immunology and Infection1
  • Clinical and Regulatory Affairs Consultancy Services (CaRACS)1
  • Eye Research Foundation1
  • Massachusetts Eye and Ear Infirmary / Harvard Medical School1
  • MedRACS Clinical Research1
  • Stanford University School of Medicine1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials