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Drug

Diethylstilbestrol

In clinical development
ClassEstrogen receptor alpha agonistEmerging researchLate-stage development
Also known as DES, Stilbestrol, Stilboestrol, Stilphostrol+9 more

DES, Stilbestrol, Stilboestrol, Stilphostrol, trans-Diethylstilbesterol, trans-Diethylstilbestrol, trans-Diethylstilboesterol, Dietilestilbestrol, Diéthylstilbestrol, (E)-3,4-bis(4-hydroxyphenyl)-3-hexene, (E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol, Diethylstilbestrolum, trans-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol.

RxNorm3390ChEMBLCHEMBL411ATCG03CB02ATCG03CC05ATCL02AA01UNII731DCA35BT
2
Research papers
Estrogen receptor
Primary target
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Phosphodiesterase and psychiatric disorders: a two-sample Mendelian randomization study.

Research2023-08-21Journal of translational medicine

Comparison Between Volatile Anesthetic-desflurane and Total Intravenous Anesthesia With Propofol and Remifentanil on Early Recovery Quality and Long Term Prognosis of Patients Undergoing Pancreatic Cancer and Common Bile Duct Cancer Surgery

Clinical trial2022-08-28Primary completion · ClinicalTrials.gov

A Randomized Phase III Trial of Dexamethasone and Aspirin (DA) Versus Dexamethasone, Diethylstilbestrol and Aspirin (DAS) in Locally Advanced or Metastatic Cancer of the Prostate - Immediate Versus Deferred Diethylstilbestrol

Clinical trial2007-04-01Completed · ClinicalTrials.gov

Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging.

Research1974-01-01The Journal of urology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Diethylstilbestrol
Aliases & brands
DESStilbestrolStilboestrolStilphostroltrans-Diethylstilbesteroltrans-Diethylstilbestroltrans-DiethylstilboesterolDietilestilbestrolDiéthylstilbestrol(E)-3,4-bis(4-hydroxyphenyl)-3-hexene(E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenolDiethylstilbestrolumtrans-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol
RxNorm CUI
3390
ChEMBL ID
CHEMBL411
ATC codes
G03CB02G03CC05L02AA01
UNII
731DCA35BT
Primary mechanism
Estrogen receptor alpha agonist

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Estrogen receptor
ESR1 · P03372
AGONISTEstrogen receptor alpha agonist

Clinical trials

2 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
2
registered trials across all phases
LATEST COMPLETION 2007
2
Late-stage (III+)
1
Completed
1
Discontinued
PHASE DISTRIBUTIONn = 2
Phase 31Phase N / A1

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

A Randomized Phase III Trial of Dexamethasone and Aspirin (DA) Versus Dexamethasone, Diethylstilbestrol and Aspirin (DAS) in Locally Advanced or Metastatic Cancer of the Prostate - Immediate Versus Deferred Diethylstilbestrol

CompletedPH IIISt. Bartholomew's Hospitaln=2602007

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19742023
Major research themes3
Autism Spectrum Disorder1Major Depressive Disorder1Mental Disorders1
Journals, researchers & institutions
Top journals
  • Journal of translational medicine1
  • The Journal of urology1
Leading researchers
  • Gleason DF1
  • Jiang M1
  • Li J1
  • Lu T1
  • Lu Z1
  • Mellinger GT1
  • Wang L1
  • Yan W1
Leading institutions
free-text, unnormalised
  • Children's Hospital Capital Institute of Pediatrics1
  • Guangdong Key Laboratory of Mental Health and Cognitive Science1
  • National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials