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Drug

Diflunisal

Approved · EMA
Late-stage development
Also known as 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid, Difluorophenylsalicylic acid, Dolobid, 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid+2 more

2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid, Difluorophenylsalicylic acid, Dolobid, 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid, 5-(2,4-difluorophenyl)salicylic acid, Diflunisalum.

1
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Diflunisal
Aliases & brands
2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acidDifluorophenylsalicylic acidDolobid2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid5-(2,4-difluorophenyl)salicylic acidDiflunisalum
RxNorm CUI
3393
ChEMBL ID
CHEMBL898
UNII
7C546U4DEN
Regulatory jurisdictions
ema

Regulatory timeline

1 event

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
2025-07-17
Latest approval
2025-07-17
Authorities
EMA
Total events
1
emaEuropean Medicines Agency· 1 event
2025-07-17Approval
Approval: Attrogy (EMA)

Indication: Attrogy is indicated for the treatment of hereditary transthyretin-mediated amyloidosis (ATTRv) in adult patients with stage 1 or stage 2 polyneuropathy.

Evidence ↗

Contains information from the European Medicines Agency (European Medicines Agency), © EMA, reused under CC BY 4.0.

Clinical trials

3 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
3
registered trials across all phases
LATEST COMPLETION 2019
2
Late-stage (III+)
2
Completed
1
Discontinued
PHASE DISTRIBUTIONn = 3
Phase 11Phase 2 / 31Phase 41

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Pilot Study of Diflunisal in HIV-infected Adults

TerminatedPH IVUniversity of British Columbian=82016

The Effect of Diflunisal on Familial Amyloidosis

CompletedPH II/IIIBoston Universityn=1302012
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.