Back to discover
Drug

Diphenhydramine

In clinical development
Emerging researchLate-stage development
Also known as 2-(benzhydryloxy)-N,N-dimethylethylamine, 2-diphenylmethoxy-N,N-demthylethanamine, 40 Winks, Acetadryl+106 more

2-(benzhydryloxy)-N,N-dimethylethylamine, 2-diphenylmethoxy-N,N-demthylethanamine, 40 Winks, Acetadryl, Airacof, Aldex-CT, Aler-Dryl, Aleve PM, Allergia-C, Allermax, Altaryl, Antihist, Banophen, Banophen Cream, Beldin, Belix, Benadryl, Benadryl Allergy Plus Congestion, Benadryl Allergy Sinus, Benadryl Itch Stopping, Benadryl-D Allergy and Sinus, Benylin Multi-Symptom, Buckley's Bedtime Formula, Bydramine, Calagel, Calagel Reformulated Jun 2019, Compoz, Derma-Pax, Di-Delamine, Difenhidramina, Diphedryl, Diphenadryl, Diphendryl, Diphenhist, DiphenhydrAMINE Topical, Diphenyl, Diphenylin, Doans PM, Dormin, Dytan, Dytan-AT, Dytan-CD, Dytan-CS, Dytan-D, Dytan-HC, Dytuss, Endal CD, Endal HD, Excedrin PM, Excedrin PM Triple Action, Genahist, Genapap PM, HC-Derma-Pax, Hydramine, Kids-Eeze Allergy, Legatrin PM, Mapap PM, Masophen PM, Motrin PM, N-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamine, Nervine, Nu-Med, Nytol, O-benzhydryldimethylaminoethanol, Panadol PM, Pardryl, Pediaclear Cough, Percogesic Reformulated Jan 2011, QlearQuil Nighttime Allergy Relief, Rest Simply, Rindal HPD, Scot-Tussin Allergy, Siladryl, Simply Sleep, Sleep-Eze, Sleepinal, Sominex, Somnapure, Somnicaps, Tact, Tavist NightTime Allergy, The Itch Eraser, Tussinate, Tusstat, Twilite, Tylenol Cold Relief Nighttime Caplet, Tylenol PM, Uni-Hist, Unisom Sleep, Unisom with Pain Relief, Valu-Dryl, Vanamine, Vetadryl, Wal-Dryl, Wal-Dryl Allergy, Wal-Dryl Childrens, Wal-Dryl PE, Wal-Dryl-D, Wal-Sleep Z, Wal-Som, Wal-Som Maximum Strength, Z-Sleep, ZZZ Sleep, ZzzQuil, Dermamycin, Actifed Allergy Day/Night, Carbetapentane/Diphenhydramine/Phenylephrine, DiphenhydrAMINE Hydrochloride, Diphenhydramine-Zinc Acetate, Diphenhydraminum.

1
Research papers
30
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

The Role of Histamines on Central Hemodynamics

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

A Phase I/II Study of Intraperitoneal Paclitaxel in Patients With Metastatic Appendiceal Adenocarcinoma

Clinical trial2026-07-16Results expected Q1 2028 · ClinicalTrials.gov

Psilocybin-facilitated Treatment for Cocaine Use

Clinical trial2026-05-18Results posted · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Diphenhydramine
Aliases & brands
2-(benzhydryloxy)-N,N-dimethylethylamine2-diphenylmethoxy-N,N-demthylethanamine40 WinksAcetadrylAiracofAldex-CTAler-DrylAleve PMAllergia-CAllermaxAltarylAntihistBanophenBanophen CreamBeldinBelixBenadrylBenadryl Allergy Plus CongestionBenadryl Allergy SinusBenadryl Itch StoppingBenadryl-D Allergy and SinusBenylin Multi-SymptomBuckley's Bedtime FormulaBydramineCalagelCalagel Reformulated Jun 2019CompozDerma-PaxDi-DelamineDifenhidraminaDiphedrylDiphenadrylDiphendrylDiphenhistDiphenhydrAMINE TopicalDiphenylDiphenylinDoans PMDorminDytanDytan-ATDytan-CDDytan-CSDytan-DDytan-HCDytussEndal CDEndal HDExcedrin PMExcedrin PM Triple ActionGenahistGenapap PMHC-Derma-PaxHydramineKids-Eeze AllergyLegatrin PMMapap PMMasophen PMMotrin PMN-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamineNervineNu-MedNytolO-benzhydryldimethylaminoethanolPanadol PMPardrylPediaclear CoughPercogesic Reformulated Jan 2011QlearQuil Nighttime Allergy ReliefRest SimplyRindal HPDScot-Tussin AllergySiladrylSimply SleepSleep-EzeSleepinalSominexSomnapureSomnicapsTactTavist NightTime AllergyThe Itch EraserTussinateTusstatTwiliteTylenol Cold Relief Nighttime CapletTylenol PMUni-HistUnisom SleepUnisom with Pain ReliefValu-DrylVanamineVetadrylWal-DrylWal-Dryl AllergyWal-Dryl ChildrensWal-Dryl PEWal-Dryl-DWal-Sleep ZWal-SomWal-Som Maximum StrengthZ-SleepZZZ SleepZzzQuilDermamycinActifed Allergy Day/NightCarbetapentane/Diphenhydramine/PhenylephrineDiphenhydrAMINE HydrochlorideDiphenhydramine-Zinc AcetateDiphenhydraminum
RxNorm CUI
3498
ChEMBL ID
CHEMBL657
ATC codes
D04AA32R06AA52R06AA02
UNII
8GTS82S83M

Clinical trials

151 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
151
registered trials across all phases
LATEST COMPLETION 2025
30
Active studies
18
Recruiting
67
Late-stage (III+)
87
Completed
34
Discontinued
PHASE DISTRIBUTIONn = 151
Early Phase 12Phase 128Phase 1 / 212Phase 242Phase 2 / 34Phase 322Phase 421Phase N / A20

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Major research themes2
Alcoholism1Hallucinogens1
Journals, researchers & institutions
Top journals
  • JAMA psychiatry1
Leading researchers
  • Baron T1
  • Bhatt S1
  • Bogenschutz MP1
  • Forcehimes AA1
  • Laska E1
  • Mennenga SE1
  • O'Donnell K1
  • Owens LT1
Leading institutions
free-text, unnormalised
  • New York University Grossman School of Medicine1
  • New York University Langone Center for Psychedelic Medicine1
  • University of Alabama at Birmingham.1
  • University of New Mexico Center on Alcohol1
  • University of New Mexico School of Medicine1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across the same disease area as Diphenhydramine in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials