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Drug

Dobutamine

In clinical development
Emerging researchLate-stage development
Also known as (±)-4-(2-((3-(p-hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol, DL-dobutamine, Dobutrex, rac-dobutamine+5 more

(±)-4-(2-((3-(p-hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol, DL-dobutamine, Dobutrex, rac-dobutamine, racemic-dobutamine, Dobutamin, Dobutamina, DOBUTamine Hydrochloride, Dobutaminum.

RxNorm3616ChEMBLCHEMBL926ATCC01CA07UNII3S12J47372
2
Research papers
4
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

The PROTECT-HIE Pilot Trial: Prophylactic Therapy to Enhance Cardiovascular Treatment in Neonatal Hypoxemic Ischemic Encephalopathy

Clinical trial2026-06-05Results expected Q2 2029 · ClinicalTrials.gov

CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock

Clinical trial2026-05-01Results expected Q4 2026 · ClinicalTrials.gov

Dobutamine During Major Abdominal Surgery: A Randomized Pilot Trial (PUSH-1)

Clinical trial2026-02-27Completed · ClinicalTrials.gov

Use of Dobutamine in Patients With Sepsis and Maintained Hypoperfusion After Initial Volemic Resuscitation.

Clinical trial2025-12-31Primary completion · ClinicalTrials.gov

Director, Head of Anesthesiology and Critical Care, Principal Investigator, Professor

Clinical trial2025-11-15Completed · ClinicalTrials.gov

Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion: a Randomized Controlled Multi-center Trial

Clinical trial2025-07-01Completed · ClinicalTrials.gov

Low-dose Dobutamine Infusion and Single-dose Tocilizumab in Acute Myocardial Infarction Patients With High Risk of Cardiogenic Shock Development - a 2x2 Multifactorial, Double-blinded, Randomized, Placebo Controlled Trial

Clinical trial2025-06-30Primary completion · ClinicalTrials.gov

Valutazione Ecocardiografica Della Riserva Contrattile Del Ventricolo Destro Dopo Carico Volemico Acuto Mediante Sollevamento Passivo Delle Gambe e Durante Infusione di Dobutamina in Pazienti Affetti da Scompenso Cardiaco a Frazione d'Eiezione Ridotta (HFrEF) e Preservata (HFpEF)

Clinical trial2025-03-20Primary completion · ClinicalTrials.gov

Can Dobutamine and Goal-Directed Fluid Therapy Improve Tissue Oxygenation in Deep Inferior Epigastric Perforator (DIEP) Flap Breast Reconstruction Surgery? Randomized Controlled Trial

Clinical trial2024-05-01Completed · ClinicalTrials.gov

Dobutamine Versus Milrinone in Management of Critically Ill Low Cardiac Output Pediatric Patients at Cairo University Children's Hospital

Clinical trial2024-03-01Primary completion · ClinicalTrials.gov

The Role of Stress Echocardiography in Valvular Heart Disease: A Current Appraisal.

Research2017-04-11Cardiology

Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses.

Research1996-06-01The New England journal of medicine

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Dobutamine
Aliases & brands
(±)-4-(2-((3-(p-hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatecholDL-dobutamineDobutrexrac-dobutamineracemic-dobutamineDobutaminDobutaminaDOBUTamine HydrochlorideDobutaminum
RxNorm CUI
3616
ChEMBL ID
CHEMBL926
ATC codes
C01CA07
UNII
3S12J47372

Clinical trials

44 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
44
registered trials across all phases
LATEST COMPLETION 2026
4
Active studies
3
Recruiting
30
Late-stage (III+)
22
Completed
18
Discontinued
PHASE DISTRIBUTIONn = 44
Early Phase 13Phase 11Phase 1 / 23Phase 27Phase 2 / 31Phase 34Phase 412Phase N / A13

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock

RecruitingPH IVOttawa Heart Institute Research Corporationn=3462026

Effect of Dobutamine on Hepatic Blood Flow During Goal-directed Hemodynamic Therapy

CompletedPH IVUniversity Hospital, Ghentn=582023

Influence of Continuous Administration of Phenylephrine Versus Dobutamine on Spinal Oxygen Saturation, Measured With Near-infrared Spectroscopy (NIRS).

CompletedPH IVUniversity Hospital, Ghentn=362022

Comparison of Milrinone Versus Dobutamine in a Heterogeneous Population of Critically Ill Patients

CompletedPH IVOttawa Heart Institute Research Corporationn=1922020

Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure Reduced Ejection Fraction and Acute Decompensation With Low Cardiac Output: A Single Center, Randomized, Non-Blinded, and Parallel Study (PRIORITY-ADHF Study)

WithdrawnPH IVMontefiore Medical Center2018

Recent completions

Trials that read out recently, adding to the completed evidence base.

Dobutamine During Major Abdominal Surgery: A Randomized Pilot Trial (PUSH-1)

CompletedN/AUniversity of Hamburg-Eppendorfn=1002026

Director, Head of Anesthesiology and Critical Care, Principal Investigator, Professor

CompletedN/AFirst Affiliated Hospital of Zhejiang Universityn=5842025

Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion: a Randomized Controlled Multi-center Trial

CompletedPH IIIUniversity Hospital, Limogesn=1362025

Can Dobutamine and Goal-Directed Fluid Therapy Improve Tissue Oxygenation in Deep Inferior Epigastric Perforator (DIEP) Flap Breast Reconstruction Surgery? Randomized Controlled Trial

CompletedPH I/IIDr. Glenio Mizubuti (MD, PhD)n=402024

Utility of Novel Echocardiographic and Invasive Haemodynamic Measurements in the Assessment of Patients Low Flow Low Gradient Aortic Stenosis Undergoing TAVI

CompletedN/AThe Royal Wolverhampton Hospitals NHS Trustn=72024

Effect of Dobutamine on Hepatic Blood Flow During Goal-directed Hemodynamic Therapy

CompletedPH IVUniversity Hospital, Ghentn=582023

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19962017
Major research themes3
Coronary Angiography1Coronary Circulation1Echocardiography, Stress1
Journals, researchers & institutions
Top journals
  • Cardiology1
  • The New England journal of medicine1
Leading researchers
  • Bartunek J Koolen JJ1
  • Bonnier HJ1
  • De Bruyne B1
  • Desai MY1
  • Gentry Iii JL1
  • Griffin BP1
  • Koolen JJ1
  • Peels K1
Leading institutions
free-text, unnormalised
  • Catharina Hospital1
  • Heart and Vascular Institute1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials