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Drug

Epigallocatechin gallate

In clinical development
Emerging researchLate-stage development
Also known as (+)-catechin 3-gallate, 3-O-GALLOYL-(-)-EPIGALLOCATECHIN, EGCG, (-)-EPIGALLOCATECHIN GALLATE+6 more

(+)-catechin 3-gallate, 3-O-GALLOYL-(-)-EPIGALLOCATECHIN, EGCG, (-)-EPIGALLOCATECHIN GALLATE, (-)-EPIGALLOCATECHIN-3-O-GALLATE, (-)-Epigallocatechin 3-gallate, EPIGALLOCATECHIN 3-O-GALLATE, Epigallo Catechin Gallate, Epigallocatechin-3-gallate, BENZOIC ACID, 3,4,5-TRIHYDROXY-, (2R,3R)-3,4-DIHYDRO-5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-2H-1-BENZOPYRAN-3-YL ESTER.

RxNorm24246ChEMBLCHEMBL297453UNIIBQM438CTEL
2
Research papers
2
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Collagen-targeted PET Imaging for Assessment of EGCG Effect

Clinical trial2026-01-08Completed · ClinicalTrials.gov

A Pilot Study to Evaluate the Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients With Curative Resections.

Clinical trial2025-09-09Completed · ClinicalTrials.gov

Phase II Randomized Controlled Trial of Epigallocatechin Gallate for Hepatocellular Carcinoma Chemoprevention

Clinical trial2025-09-05Results expected Q3 2028 · ClinicalTrials.gov

Clinical Study of EGCG for the Prevention and Treatment of Peripheral Neuropathy Induced by Taxane (TIPN)

Clinical trial2024-11-30Primary completion · ClinicalTrials.gov

Study of of Oxygen Nebulized Inhalation EGCG in Cancer Patients With New Coronary：Phase II Clinical Trial

Clinical trial2024-07-02Completed · ClinicalTrials.gov

Epigallocatechin gallate improves neuronal damage in animal model of ischemic stroke and glutamate-exposed neurons via modulation of hippocalcin expression.

Research2024-03-01PloS one

Oxygen Atomizing Inhalation of EGCG in the Treatment Interstitial Pneumonia in Cancer Patients: Phase I-II Clinical Trial

Clinical trial2023-12-31Primary completion · ClinicalTrials.gov

Pharmacokinetics and Hepatic Safety of EGCG

Clinical trial2023-06-05Results posted · ClinicalTrials.gov

Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis.

Clinical trial2022-12-22Results posted · ClinicalTrials.gov

Phase Ⅰ,ⅡStudy of Topically Applied Green Tea Extract for Prevention and Treatment of Radio Dermatitis and Radiation Mucositis

Clinical trial2022-06-01Primary completion · ClinicalTrials.gov

Study of Epigallocatechin-3-gallate (EGCG) for Esophagus Protection in Patients With Lung Cancer Receiving Radial Radiotherapy

Clinical trial2022-06-01Primary completion · ClinicalTrials.gov

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation.

Research2019-12-23Molecules (Basel, Switzerland)

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Epigallocatechin gallate
Aliases & brands
(+)-catechin 3-gallate3-O-GALLOYL-(-)-EPIGALLOCATECHINEGCG(-)-EPIGALLOCATECHIN GALLATE(-)-EPIGALLOCATECHIN-3-O-GALLATE(-)-Epigallocatechin 3-gallateEPIGALLOCATECHIN 3-O-GALLATEEpigallo Catechin GallateEpigallocatechin-3-gallateBENZOIC ACID, 3,4,5-TRIHYDROXY-, (2R,3R)-3,4-DIHYDRO-5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-2H-1-BENZOPYRAN-3-YL ESTER
RxNorm CUI
24246
ChEMBL ID
CHEMBL297453
UNII
BQM438CTEL

Clinical trials

17 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
17
registered trials across all phases
LATEST COMPLETION 2026
2
Active studies
2
Recruiting
1
Late-stage (III+)
8
Completed
7
Discontinued
PHASE DISTRIBUTIONn = 17
Early Phase 12Phase 12Phase 1 / 23Phase 29Phase 2 / 31

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

The Effect of Extract of Green Tea on Obese Women Obese Related Hormone Peptides

Unknown statusPH II/IIITaipei City Hospitaln=922014

Recent completions

Trials that read out recently, adding to the completed evidence base.

Collagen-targeted PET Imaging for Assessment of EGCG Effect

CompletedPH IHal Chapmann=122026

A Pilot Study to Evaluate the Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients With Curative Resections.

CompletedPH IThe University of Texas Health Science Center at San Antonion=512025

Study of of Oxygen Nebulized Inhalation EGCG in Cancer Patients With New Coronary：Phase II Clinical Trial

CompletedPH IIShandong Cancer Hospital and Instituten=1112024

Pharmacokinetics and Hepatic Safety of EGCG

CompletedPH IYale Universityn=392022

Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis.

CompletedPH IHal Chapmann=352019

A Randomised Trial for the Treatment of Cardiac AMyloid Light-chain Amyloidosis With the Green Tea Compound Epigallocatechin-3-gallate (TAME-AL)

CompletedPH IIFlorian Micheln=382017

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20192024
Major research themes3
Catechin1Ischemic Stroke1Neuroprotective Agents1
Journals, researchers & institutions
Top journals
  • Molecules (Basel, Switzerland)1
  • PloS one1
Leading researchers
  • Cannataro R1
  • Caroleo MC1
  • Cione E1
  • Gallelli L1
  • Kang JB1
  • Koh PO1
  • La Torre C1
  • Park DJ1
Leading institutions
free-text, unnormalised
  • College of Veterinary Medicine1
  • School of Medicine1
  • University of Calabria1

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Catechin

Studied across 3 of the same disease areas as Epigallocatechin gallate in the shared literature.

3 shared diseases2 shared papers
Quercetin

Frequently co-studied with Epigallocatechin gallate in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials