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Drug

Gadolinium

Approved medicine
ResearchActive indication expansion

Also known as Gd, gadolinio.

RxNorm1310171ChEMBLCHEMBL1232993UNIIAU0V1LM3JT
3
Research papers
5
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance in Non-Squamous Locally Advanced Non-Small Cell Lung Cancer

Clinical trial2026-07-17Results expected Q2 2028 · ClinicalTrials.gov

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

Clinical trial2026-07-08Results expected Q3 2030 · ClinicalTrials.gov

PET/MR, PET/CT and Whole Body MR in Newly Diagnosed Acute Myeloid Leukemia (AML)

Clinical trial2026-04-17Results expected Q3 2027 · ClinicalTrials.gov

The Feasibility of Steady State CBV Mapping Using Ferumoxytol Immediately After Gadolinium Enhanced MRI of the CNS

Clinical trial2026-02-27Results expected Q4 2027 · ClinicalTrials.gov

Phase 2 Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) With Gemcitabine Followed by Systemic Adjuvant Chemotherapy With Dacarbazine for Locally Recurrent Uterine Leiomyosarcoma (LMS)

Clinical trial2026-02-11Completed · ClinicalTrials.gov

Metabolic Imaging of the Heart Using Hyperpolarized (13C) Pyruvate Injection

Clinical trial2026-01-29Results expected Q2 2027 · ClinicalTrials.gov

A Phase 1 Study of Tumor Treating Fields With 5 Day Hypofractionated Stereotactic Radiosurgery and Concurrent and Maintenance Temozolomide in Newly Diagnosed Glioblastoma

Clinical trial2025-09-02Completed · ClinicalTrials.gov

A Pilot Study to Assess Lactate and Bicarbonate Detection Within Malignant Brain Tumors Using [1-13C]-Pyruvate DNP Magnetic Resonance Spectroscopy (MRS)

Clinical trial2023-12-21Results posted · ClinicalTrials.gov

Phenotyping of giant cell myocarditis versus cardiac sarcoidosis using cardiovascular magnetic resonance.

Research2023-06-25International journal of cardiology

Imaging Vascular Properties of Pediatric Brain Tumors Using DSC-MRI With Ferumoxytol (Code 7228) and DCE-MRI With Gadolinium in a Single Imaging Session: An NCI Sponsored Exploratory Trial

Clinical trial2022-08-03Results posted · ClinicalTrials.gov

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).

Research2020-11-01JAMA cardiology

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis.

Research2008-02-01The New England journal of medicine

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Gadolinium
Aliases & brands
Gdgadolinio
RxNorm CUI
1310171
ChEMBL ID
CHEMBL1232993
UNII
AU0V1LM3JT

Clinical trials

25 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
25
registered trials across all phases
LATEST COMPLETION 2026
5
Active studies
5
Recruiting
9
Late-stage (III+)
11
Completed
9
Discontinued
PHASE DISTRIBUTIONn = 25
Early Phase 12Phase 16Phase 1 / 24Phase 24Phase 2 / 31Phase 44Phase N / A4

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease

TerminatedPH IVUniversity Hospital, Grenoblen=232020

Efficacy of Gadolinium Contrast in CT Pulmonary Angiography in Patients With Allergy to Iodine

WithdrawnPH IVMassachusetts General Hospital2019

Gadolinium Enhanced Dual-Energy Computed Tomography: A Feasibility Study to Assess Image Quality and Diagnostic Confidence

WithdrawnPH IVMassachusetts General Hospital2018

Stress Cardiac MRI Using Regadenoson for Evaluation of Nonspecific Allograft Dysfunction

CompletedPH IVPaul Kimn=142016

Comprehensive Evaluation of Ischemic Heart Disease Using MRI

CompletedPH II/IIINorthwestern Universityn=402012

Recent completions

Trials that read out recently, adding to the completed evidence base.

Phase 2 Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) With Gemcitabine Followed by Systemic Adjuvant Chemotherapy With Dacarbazine for Locally Recurrent Uterine Leiomyosarcoma (LMS)

CompletedPH IIStanford Universityn=172026

A Phase 1 Study of Tumor Treating Fields With 5 Day Hypofractionated Stereotactic Radiosurgery and Concurrent and Maintenance Temozolomide in Newly Diagnosed Glioblastoma

CompletedPH IStanford Universityn=122025

Chronic Convection Enhanced Delivery of Topotecan for Recurrent High Grade Gliomas

CompletedPH IColumbia Universityn=52021

A Pilot Study to Assess Lactate and Bicarbonate Detection Within Malignant Brain Tumors Using [1-13C]-Pyruvate DNP Magnetic Resonance Spectroscopy (MRS)

CompletedPH IDaniel M. Spielmann=92019

Cardiac Structure and Function in Acromegalic Patients: A Cardiac Magnetic Resonance Imaging Study

CompletedN/AAssistance Publique - Hôpitaux de Parisn=282019

Imaging Vascular Properties of Pediatric Brain Tumors Using DSC-MRI With Ferumoxytol (Code 7228) and DCE-MRI With Gadolinium in a Single Imaging Session: An NCI Sponsored Exploratory Trial

CompletedPH IOHSU Knight Cancer Instituten=142018

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20082023
Major research themes2
Myocarditis1Sarcoidosis1
Journals, researchers & institutions
Top journals
  • International journal of cardiology1
  • JAMA cardiology1
  • The New England journal of medicine1
Leading researchers
  • Agarwal S1
  • Antel J1
  • Arendt C1
  • Arnold DL1
  • Bar-Or A1
  • Bergh N1
  • Björkenstam M1
  • Bobbio E1
Leading institutions
free-text, unnormalised
  • Department of Clinical Pathology1
  • Department of Clinical Physiology1
  • Department of Hospital Therapy No. 11
  • Goethe University Hospital Frankfurt1
  • Institute for Cardiac Diagnostic and Therapy1
  • Institute for Experimental and Translational Cardiovascular Imaging1

Related diseases

1 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Active research areas
Myocarditis2

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Rituximab

Studied across the same disease area as Gadolinium in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials