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Drug

Galantamine

In clinical development
Emerging researchLate-stage development
Also known as Razadyne, Reminyl, (-)-Galanthamine, Galantamina+2 more

Razadyne, Reminyl, (-)-Galanthamine, Galantamina, Galanthamine, Galantamine Hydrobromide.

RxNorm4637ChEMBLCHEMBL659ATCN06DA04UNII0D3Q044KCA
2
Research papers
2
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans

Clinical trial2026-05-18Results expected Q2 2027 · ClinicalTrials.gov

Exploration of the Efficacy and Mechanism of Galantamine (an Extract From Lycoris Aurea) in Treating Ischemic Stroke Based on the Neurovascular Unit

Clinical trial2025-09-16Results expected Q3 2028 · ClinicalTrials.gov

Targeting the Cholinergic Pathway in HIV-associated Inflammation and Cognitive Dysfunction

Clinical trial2024-10-17Results posted · ClinicalTrials.gov

Effects of Galantamine on Cognition

Clinical trial2022-06-08Results posted · ClinicalTrials.gov

Oxytocin or Galantamine vs. Placebo for the Treatment of Negative Symptoms and Cognitive Impairments in Schizophrenia

Clinical trial2022-01-12Results posted · ClinicalTrials.gov

A Pilot Parallel Double-Blind, Randomized Trial of Galantamine for Subarachnoid Hemorrhage

Clinical trial2021-10-08Results posted · ClinicalTrials.gov

Galantamine Effects on Cognitive Function in Abstinent Cocaine Users

Clinical trial2021-03-15Results posted · ClinicalTrials.gov

Treating disorders across the lifespan by modulating cholinergic signaling with galantamine.

Research2021-01-08Journal of neurochemistry

Adjunctive Galantamine for Treatment of Cognitive Impairments in Patients With Schizophrenia

Clinical trial2020-12-16Results posted · ClinicalTrials.gov

Cholinergic Enhancement as a Treatment for Nicotine Addiction

Clinical trial2020-03-23Results posted · ClinicalTrials.gov

Racial Differences in Vagal Control of Glucose Homeostasis

Clinical trial2019-03-19Results posted · ClinicalTrials.gov

An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in elderly cognitively impaired stroke patients.

Research2008-07-31Cerebrovascular diseases (Basel, Switzerland)

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Galantamine
Aliases & brands
RazadyneReminyl(-)-GalanthamineGalantaminaGalanthamineGalantamine Hydrobromide
RxNorm CUI
4637
ChEMBL ID
CHEMBL659
ATC codes
N06DA04
UNII
0D3Q044KCA

Clinical trials

53 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
53
registered trials across all phases
LATEST COMPLETION 2022
2
Active studies
2
Recruiting
36
Late-stage (III+)
38
Completed
13
Discontinued
PHASE DISTRIBUTIONn = 53
Phase 15Phase 1 / 23Phase 29Phase 2 / 33Phase 39Phase 416Phase N / A8

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Effects of Cholinergic Stimulation on Visceral Fat, Oxidative Stress and Inflammatory Markers in Patients With Metabolic Syndrome: a Randomized Clinical Trial

CompletedPH IVUniversity of Sao Paulon=602017

Evaluation of Efficacy and Safety of Galantamine in Subjects With Dementia of Alzheimer's Type Who Failed to Benefit From Donepezil

CompletedPH IVJanssen Pharmaceutical K.K.n=1022013

Phase IV Study for the Assessment of Modulating Effect of Galantamine (Reminyl PRC) on Circadian Rhythm in Patients With Moderate Alzheimer's Disease

TerminatedPH IVJanssen-Cilag, S.A.n=12011

The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life

CompletedPH IVJanssen-Cilag Farmaceutica Ltda.n=222009

The Efficacy of Galantamine Treatment on Attention in Patients With Alzheimer's Disease

CompletedPH IVJanssen Korea, Ltd., Korean=992009

Recent completions

Trials that read out recently, adding to the completed evidence base.

Targeting the Cholinergic Pathway in HIV-associated Inflammation and Cognitive Dysfunction

CompletedPH IIUniversity of Pennsylvanian=632022

A Pilot Parallel Double-Blind, Randomized Trial of Galantamine for Subarachnoid Hemorrhage

CompletedPH I/IIThe University of Texas Health Science Center, Houstonn=602019

Repurposing Cholinesterase Inhibitors for Smoking Cessation.

CompletedPH IIUniversity of Pennsylvanian=982017

Racial Differences in Vagal Control of Glucose Homeostasis

CompletedPH I/IIVanderbilt University Medical Centern=232017

Effects of Cholinergic Stimulation on Visceral Fat, Oxidative Stress and Inflammatory Markers in Patients With Metabolic Syndrome: a Randomized Clinical Trial

CompletedPH IVUniversity of Sao Paulon=602017

Evaluation de l'efficacité de la Galantamine Versus Placebo associée à Une Revalidation Neuropsychologique Chez Des Patients présentant un Trouble Cognitif après un Premier Infarctus cérébral : étude en Neuroimagerie Fonctionnelle

CompletedPH IIInstitut National de la Santé Et de la Recherche Médicale, Francen=472016

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20082021
Journals, researchers & institutions
Top journals
  • Cerebrovascular diseases (Basel, Switzerland)1
  • Journal of neurochemistry1
Leading researchers
  • Butters M1
  • Cabacungan L1
  • Dew MA1
  • Koenig K1
  • Lenze EJ1
  • Metz CN1
  • Mulsant BH1
  • Munin MC1
Leading institutions
free-text, unnormalised
  • Donald and Barbara Zucker School of Medicine at Hofstra/Northwell1
  • The Feinstein Institutes for Medical Research1
  • Washington University School of Medicine1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials