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Drug

Genistein

In clinical development
Emerging researchLate-stage development
Also known as Genisteol, Genisterin, 4',5,7-trihydroxyisoflavone, 4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-+3 more

Genisteol, Genisterin, 4',5,7-trihydroxyisoflavone, 4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-, 5,7,4'-trihydroxyisoflavone, 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-chromen-4-one.

RxNorm25696ChEMBLCHEMBL44UNIIDH2M523P0H
2
Research papers
3
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Exploring a Natural Solution for Childhood Obesity

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

A Pilot Clinical Trial of Cardiovascular Genistein Therapy for Heart Failure Inflammation

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

Cardiovascular Genistein Therapy for Heart Failure Inflammation

Clinical trial2025-09-01Primary completion · ClinicalTrials.gov

Daidzein and Genistein: Natural Phytoestrogens with Potential Applications in Hormone Replacement Therapy.

Research2025-07-20International journal of molecular sciences

Phase II Randomized Placebo-Controlled Clinical Trial of Genistein in Reducing the Toxicity and Improving the Efficacy of Intravesical Therapy

Clinical trial2025-02-05Results posted · ClinicalTrials.gov

Phase II Trial of Gemcitabine and Genistein in Metastatic Breast Cancer Patients With Biomarker Assays

Clinical trial2023-06-22Results posted · ClinicalTrials.gov

A Randomized, Placebo-Controlled Pilot Study of Genistein Supplementation in Pediatric Cancer Patients Receiving Myelosuppressive Chemotherapy

Clinical trial2021-09-01Terminated · ClinicalTrials.gov

Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate Cancer

Clinical trial2021-07-23Terminated · ClinicalTrials.gov

Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits.

Research2021-07-19Oxidative medicine and cellular longevity

Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer

Clinical trial2021-06-10Results posted · ClinicalTrials.gov

Phase II Trial of Novasoy®, Gemcitabine, and Erlotinib in Locally Advanced or Metastatic Pancreatic Cancer

Clinical trial2021-03-01Results posted · ClinicalTrials.gov

The Effect of Genistein (Supro®) on Coronary Artery Diameter and Blood Flow in Men and Women With Coronary Heart Disease

Clinical trial2019-08-05Results posted · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Genistein
Aliases & brands
GenisteolGenisterin4',5,7-trihydroxyisoflavone4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-5,7,4'-trihydroxyisoflavone5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one5,7-dihydroxy-3-(4-hydroxyphenyl)-chromen-4-one
RxNorm CUI
25696
ChEMBL ID
CHEMBL44
UNII
DH2M523P0H

Clinical trials

19 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
19
registered trials across all phases
LATEST COMPLETION 2024
3
Active studies
3
Recruiting
2
Late-stage (III+)
12
Completed
4
Discontinued
PHASE DISTRIBUTIONn = 19
Early Phase 11Phase 11Phase 1 / 25Phase 210Phase 2 / 32

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Vascular and Skeletal Protective Effects of Genistein in Postmenopausal Women

CompletedPH II/IIIUniversity of Messinan=4002005

The Effect of Genistein (Supro®) on Coronary Artery Diameter and Blood Flow in Men and Women With Coronary Heart Disease

CompletedPH II/IIIImperial College Londonn=712003

Recent completions

Trials that read out recently, adding to the completed evidence base.

Phase II Randomized Placebo-Controlled Clinical Trial of Genistein in Reducing the Toxicity and Improving the Efficacy of Intravesical Therapy

CompletedPH IIEmory Universityn=362024

Genistein Combined With FOLFOX or FOLFOX-Avastin for Treatment of Metastatic Colorectal Cancer: Phase I/II Pilot Study

CompletedPH I/IISofya Pintovan=132018

Phase IIA, Randomized Placebo-Controlled Trial of Single High Dose Cholecalciferol and Daily Genistein (G-2535) Versus Placebo in Men With Early Stage Prostate Cancer Undergoing Prostatectomy

CompletedPH IINational Cancer Institute (NCI)n=152014

A Pilot Study of the Effect of Genistein in Combination With High-Dose Interleukin-2 on Cell Expansion and Gene Expression in Patients With Metastatic Melanoma or Renal Cell Carcinoma

CompletedPH INorthwestern Universityn=152014

Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer

CompletedPH IINational Cancer Institute (NCI)n=602010

Phase II Trial of Novasoy®, Gemcitabine, and Erlotinib in Locally Advanced or Metastatic Pancreatic Cancer

CompletedPH IIBarbara Ann Karmanos Cancer Instituten=202010

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20212025
Major research themes4
Genistein1Hormone Replacement Therapy1Isoflavones1Phytoestrogens1
Journals, researchers & institutions
Top journals
  • International journal of molecular sciences1
  • Oxidative medicine and cellular longevity1
Leading researchers
  • Ahmad B1
  • Arunotayanun W1
  • Atif M1
  • Butnariu M1
  • Calina D1
  • Cardoso SM1
  • Chaichit S1
  • Chaikhong K1
Leading institutions
free-text, unnormalised
  • Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara1
  • Bayero University Kano1
  • Center for Medical and Health Technology Assessment (CM-HTA)1
  • Center of Biotechnology and Microbiology1
  • Center of Excellence on Natural Products for Neuroprotection and Anti-Ageing1
  • Chiang Mai University1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Daidzein

Frequently co-studied with Genistein in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials