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Drug

Histamine

In clinical development
Emerging researchLate-stage development
Also known as 1H-Imidazole-4-ethanamine, 2-(4-imidazolyl)ethylamine, 4-imidazoleethylamine, 5-imidazoleethylamine+6 more

1H-Imidazole-4-ethanamine, 2-(4-imidazolyl)ethylamine, 4-imidazoleethylamine, 5-imidazoleethylamine, ActivOn Arthritis, Alo, Australian Dream, beta-aminoethylglyoxaline, beta-aminoethylimidazole, Histamine Phosphate.

RxNorm5333ChEMBLCHEMBL90UNII820484N8I3
1
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

An Open Label, Single Centre, Enabling Study to Investigate the Optimum Method for Use of Intradermal Substance P as a Challenge Agent in Healthy Participants

Clinical trial2025-01-20Results posted · ClinicalTrials.gov

Effect of Ketamine, Amitriptyline and Their Combination on Histaminergic and Non-histaminergic Itch

Clinical trial2024-12-31Completed · ClinicalTrials.gov

Immunologic Profile of Chronically Photodamaged Skin

Clinical trial2023-02-23Completed · ClinicalTrials.gov

Skin Prick Test of KeraStat® Cream

Clinical trial2022-11-15Results posted · ClinicalTrials.gov

Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor

Clinical trial2022-06-30Completed · ClinicalTrials.gov

Characterization of the Toll-like Receptor 7-agonist Imiquimod 3.75% As a New Surrogate Model of Itch

Clinical trial2022-06-01Withdrawn · ClinicalTrials.gov

Effect of Intradermal Morphine Application on Histaminergic and Non-histaminergic Itch and Related TRPV1 and Antihistamine Treatments (2nd Sub-project)

Clinical trial2021-12-31Completed · ClinicalTrials.gov

Characterization of Bovine Adrenal Medulla (BAM8-22) as a New Surrogate Model of Non-histaminergic Itch

Clinical trial2021-06-01Completed · ClinicalTrials.gov

A Mechanistic Study on Morphine-induced Orthogonal Neural Plasticity for Itch and Pain Processing in Humans (a Relation of Morphine-induced Itch and Pain Processing)

Clinical trial2020-07-07Completed · ClinicalTrials.gov

En Mekanistisk undersøgelse af Interaktioner Imellem Det Thermoceptive og Det Pruriceptive Sensoriske System

Clinical trial2019-08-28Completed · ClinicalTrials.gov

Middle Ear Pressure Regulation in Health and Disease -- Gas Supply, Demand and Middle Ear Gas Balance -- Specific Aim 2

Clinical trial2019-03-22Completed · ClinicalTrials.gov

Intestinal permeability--a new target for disease prevention and therapy.

Research2014-11-18BMC gastroenterology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Histamine
Aliases & brands
1H-Imidazole-4-ethanamine2-(4-imidazolyl)ethylamine4-imidazoleethylamine5-imidazoleethylamineActivOn ArthritisAloAustralian Dreambeta-aminoethylglyoxalinebeta-aminoethylimidazoleHistamine Phosphate
RxNorm CUI
5333
ChEMBL ID
CHEMBL90
UNII
820484N8I3

Clinical trials

18 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
18
registered trials across all phases
LATEST COMPLETION 2024
12
Late-stage (III+)
15
Completed
3
Discontinued
PHASE DISTRIBUTIONn = 18
Phase 13Phase 23Phase 31Phase N / A11

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

A Multicenter, Randomized, Double Blind, Active Controlled, Parallel Group, Clinical Study, to Evaluate the Safety and Efficacy of Apitox vs Histamine in Subjects With Refractory Osteoarthritis Pain and Inflammation of the Knee

CompletedPH IIIApimeds, Inc.n=3632016

Recent completions

Trials that read out recently, adding to the completed evidence base.

Effect of Ketamine, Amitriptyline and Their Combination on Histaminergic and Non-histaminergic Itch

CompletedN/AAalborg Universityn=302024

Immunologic Profile of Chronically Photodamaged Skin

CompletedPH IUniversity of Michigann=402023

Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor

CompletedN/AAalborg Universityn=202022

Effect of Intradermal Morphine Application on Histaminergic and Non-histaminergic Itch and Related TRPV1 and Antihistamine Treatments (2nd Sub-project)

CompletedN/AAalborg Universityn=262021

An Open Label, Single Centre, Enabling Study to Investigate the Optimum Method for Use of Intradermal Substance P as a Challenge Agent in Healthy Participants

CompletedN/AGlaxoSmithKlinen=322021

Characterization of Bovine Adrenal Medulla (BAM8-22) as a New Surrogate Model of Non-histaminergic Itch

CompletedN/AAalborg Universityn=242021

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Intestinal permeability--a new target for disease prevention and therapy.

BMC gastroenterology · 2014 · 1,186 cites
Recent papers

Intestinal permeability--a new target for disease prevention and therapy.

BMC gastroenterology · 2014 · 1,186 cites
Journals, researchers & institutions
Top journals
  • BMC gastroenterology1
Leading researchers
  • Barbara G1
  • Bischoff SC1
  • Buurman W1
  • Ockhuizen T1
  • Schulzke JD1
  • Serino M1
  • Tilg H1
  • Watson A1
Leading institutions
free-text, unnormalised
  • Department of Medical and Surgical Sciences and Centre for Applied Biomedical Research1
  • Institut National de la Santé et de la Recherche Médicale (INSERM) & Université Paul Sabatier (UPS)1
  • Maastricht University Medical Centre1
  • Medical University Innsbruck1
  • Norwich Medical School1
  • University of Hohenheim1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials