Drug

Hydromorphone

In clinical development

Emerging researchLate-stage development

Also known as Dihydromorfinon, Dihydromorphinone, Dilaudid, Dilaudid Cough+11 more

Dihydromorfinon, Dihydromorphinone, Dilaudid, Dilaudid Cough, Exalgo, Hidromorfona, Hydromorfona, Idromorfone, Palladone, 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one, 4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone, 6-Deoxy-7,8-dihydro-6-oxomorphine, 7,8-Dihydromorphinone, HYDROmorphone Hydrochloride, Hydromorphonum.

RxNorm3423UNIIQ812464R06

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Randomized, Unblinded, Phase III Trial of Thoracic Epidural Analgesia Versus Four-Quadrant Transversus Abdominus Plane Block in Oncologic Open-Incision Liver Surgery

Clinical trial2026-07-08Results expected Q3 2027 · ClinicalTrials.gov

Randomized Clinical Trial of Methadone and Ketamine for Pain Management During Deceased Donor Liver Transplant

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department: a Randomized Controlled Study

Clinical trial2026-06-29Results expected Q4 2026 · ClinicalTrials.gov

Most Effective Opioid Analgesia in Ambulatory Surgeries: a Randomized Control, Investigator Blinded, Parallel Group With Superiority Design Study of Morphine Versus Hydromorphone

Clinical trial2026-06-23Results posted · ClinicalTrials.gov

Effect of Opioid Infusion Rate on Abuse Liability Potential and Analgesic Efficacy of Intravenous Hydromorphone Among Inpatients With Cancer Pain: A Randomized Crossover Trial

Clinical trial2026-06-16Results expected Q4 2027 · ClinicalTrials.gov

Fentanyl Versus Hydromorphone as First Line Strategy in Patients on Mechanical Ventilation, a Pilot Pragmatic Randomized Superiority Clinical Trial: the FenHydro Trial

Clinical trial2026-05-01Primary completion · ClinicalTrials.gov

Glutamatergic Mechanisms in Opioid and Cocaine Co-Use

Clinical trial2026-03-27Completed · ClinicalTrials.gov

Methadone Versus Intrathecal Hydromorphone for Postoperative Analgesia in Patients Undergoing Surgery for Gynecologic Malignancy Via Midline Laparotomy Receiving Liposomal Bupivacaine

Clinical trial2026-03-04Results expected Q3 2029 · ClinicalTrials.gov

Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy: A Prospective, Randomized, Non-Inferiority Trial

Clinical trial2026-02-03Results expected Q1 2027 · ClinicalTrials.gov

Personalized Post-Operative Opiate Prescriptions Based on Pharmacogenetics of CytochromeP450, COMT, and OPRM1

Clinical trial2025-12-01Primary completion · ClinicalTrials.gov

Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)

Clinical trial2025-11-19Results posted · ClinicalTrials.gov

Intranasal hydromorphone for treatment of acute pain in children: A pilot study.

Research2019-03-13The American journal of emergency medicine

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Hydromorphone

Aliases & brands

DihydromorfinonDihydromorphinoneDilaudidDilaudid CoughExalgoHidromorfonaHydromorfonaIdromorfonePalladone4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone6-Deoxy-7,8-dihydro-6-oxomorphine7,8-DihydromorphinoneHYDROmorphone HydrochlorideHydromorphonum

RxNorm CUI

3423

UNII

Q812464R06