Drug

Imipramine

In clinical development

Emerging researchLate-stage development

Also known as Imipramine Pamoate, N-(gamma-Dimethylaminopropyl)iminodibenzyl, Tofranil, Tofranil-PM+4 more

Imipramine Pamoate, N-(gamma-Dimethylaminopropyl)iminodibenzyl, Tofranil, Tofranil-PM, Imipramin, Imipramina, Imipramine Hydrochloride, Imipraminum.

RxNorm5691 ChEMBLCHEMBL11 ATCN06AA02UNIIOGG85SX4E4

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Pilot Studies Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea

Clinical trial2026-02-18Results expected Q4 2028 · ClinicalTrials.gov

Acid Sphingomyelinase Inhibition to Mitigate the Environmental Exposure Risks of Ultraviolet Light-Induced Actinic Neoplasia and Squamous Cell Carcinoma in US Veterans

Clinical trial2025-12-22Results expected Q1 2029 · ClinicalTrials.gov

Comparisons of the Impact of Duloxetine Versus Imipramine on Therapeutic Efficacy in Women With Stress Urinary Incontinence: a Randomized Controlled Study.

Clinical trial2024-12-31Primary completion · ClinicalTrials.gov

Outcome of Treatment of Monosymptomatic Nocturnal Enuresis in Children Using Imipramine Alone Versus Sulbutiamine Alone Versus Imipramine Plus Sulbutiamine : Prospective Comparative Study

Clinical trial2024-09-01Primary completion · ClinicalTrials.gov

Pilot Studies Testing the Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy

Clinical trial2024-04-24Results expected Q1 2028 · ClinicalTrials.gov

A Pre-Surgical Window of Opportunity Trial Investigating the Effect of Imipramine on Previously Untreated Breast Cancer (CTMS# 17-0037)

Clinical trial2022-05-01Completed · ClinicalTrials.gov

Comparisons of the Impact of Duloxetine Versus Imipramine on Therapeutic Efficacy, Psychological Distress, Sexual Function, Urethral and Bladder Wall Structure and Blood Flow in Women With Stress Urinary Incontinence: a Randomized Controlled Study

Clinical trial2021-06-03Withdrawn · ClinicalTrials.gov

Dichotic Listening as a Predictor of Placebo and Medication Response in Depression

Clinical trial2019-05-30Results posted · ClinicalTrials.gov

Dichotic Listening as a Predictor of Medication Response in Depression

Clinical trial2018-04-30Results posted · ClinicalTrials.gov

A Single Dose, 2-Period, 2-Treatment, 2-Way Crossover Bioequivalency Study of Imipramine Pamoate Capsules, 75 mg, Under Fasted Conditions

Clinical trial2018-02-05Results posted · ClinicalTrials.gov

Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus.

Research2005-02-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects.

Research2003-01-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Imipramine

Aliases & brands

Imipramine PamoateN-(gamma-Dimethylaminopropyl)iminodibenzylTofranilTofranil-PMImipraminImipraminaImipramine HydrochlorideImipraminum

RxNorm CUI

5691

ChEMBL ID

CHEMBL11

ATC codes

N06AA02

UNII

OGG85SX4E4

Clinical trials

26 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2022

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 26

Early Phase 11Phase 11Phase 1 / 21Phase 24Phase 39Phase 44Phase N / A6

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Randomised, Double-blind, Placebo-controlled Trial of the Effect of the Combination of Imipramine and Pregabalin for the Treatment of Painful Polyneuropathy

Unknown statusPH IVOdense University Hospitaln=752013

Dichotic Listening as a Predictor of Medication Response in Depression

CompletedPH IVNew York State Psychiatric Instituten=172011

Medication Treatment Following Neuropsychologic, Dichotic and f-MRI Tests in Depressed Outpatients With Repeat f-MRI Following Treatment

CompletedPH IVNew York State Psychiatric Instituten=282007

Maintenance Therapies in Recurrent Depression-Study I

CompletedPH IVUniversity of Pittsburghn=2001993

Comparisons of the Impact of Duloxetine Versus Imipramine on Therapeutic Efficacy in Women With Stress Urinary Incontinence: a Randomized Controlled Study.

Unknown statusPH IIIFar Eastern Memorial Hospitaln=902024

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Pre-Surgical Window of Opportunity Trial Investigating the Effect of Imipramine on Previously Untreated Breast Cancer (CTMS# 17-0037)

CompletedPH IThe University of Texas Health Science Center at San Antonion=172022

Treatment of Multi-organ Bodily Distress Syndrome. A Double-blinded Placebo Controlled Trial of the Effects of Imipramine (Stress-3)

CompletedPH IIUniversity of Aarhusn=1382016

Linking Altered Central Pain Processing and Genetic Polymorphism to Drug Efficacy in Chronic Low Back Pain

CompletedPH IIIInsel Gruppe AG, University Hospital Bernn=1502015

Efficacy of Imipramine for Treatment of Patients With Esophageal

CompletedPH IIIMahidol Universityn=832013

Dichotic Listening as a Predictor of Medication Response in Depression

CompletedPH IVNew York State Psychiatric Instituten=172011

Dichotic Listening as a Predictor of Placebo and Medication Response in Depression

CompletedPH I/IINew York State Psychiatric Instituten=252011

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20032005

Most influential

Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003 · 593 cites

Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005 · 592 cites

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Fluoxetine

Frequently co-studied with Imipramine in the research literature.

2 shared papers

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials