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Drug

Insulin Lispro

Approved · EMA
ClassInsulin receptor agonistEmerging researchLate-stage developmentSteady momentum
Also known as Admelog, HumaLOG, Humalog Mix, Lispro PRC+6 more

Admelog, HumaLOG, Humalog Mix, Lispro PRC, Lispro insulin, Lyumjev, Insulina lispro, INSULIN,LISPRO,HUMAN/rDNA, Insulin lispro protamine recombinant, Insulin lispro recombinant.

5
Research papers
5
Active clinical trials
Insulin receptor
Primary target
5
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Approval: Bysumlog (EMA)

Regulatory2026-05-06EMA

Do Antipsychotics Block Insulin Action in the Brain: is it a Class Effect?

Clinical trial2026-04-02Results expected Q3 2028 · ClinicalTrials.gov

Approval: Liprolog (EMA)

Regulatory2001-08-01EMA

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Insulin Lispro
Aliases & brands
AdmelogHumaLOGHumalog MixLispro PRCLispro insulinLyumjevInsulina lisproINSULIN,LISPRO,HUMAN/rDNAInsulin lispro protamine recombinantInsulin lispro recombinant
RxNorm CUI
86009
ChEMBL ID
CHEMBL1201538
ATC codes
A10AB04A10AC04
UNII
GFX7QIS1II
Primary mechanism
Insulin receptor agonist
Regulatory jurisdictions
ema

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Insulin receptor
INSR · P06213
AGONISTInsulin receptor agonist

Regulatory timeline

5 events

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
1996-04-30
Latest approval
2026-05-06
Authorities
EMA
Total events
5
emaEuropean Medicines Agency· 5 events
2026-05-06Approval
Approval: Bysumlog (EMA)
Indication: For the treatment of adults and children with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. Bysumlog is also indicated for the initialShow full indication

For the treatment of adults and children with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. Bysumlog is also indicated for the initial stabilisation of diabetes mellitus.

Evidence ↗
2020-03-24Approval
Approval: Lyumjev (previously Liumjev) (EMA)

Indication: Treatment of diabetes mellitus in adults, adolescents and children aged 1 year and above. Treatment of diabetes mellitus in adults.

Evidence ↗
2017-07-19Approval
Approval: Insulin lispro Sanofi (EMA)
Indication: For the treatment of adults and children with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. Insulin lispro Sanofi is also indicated forShow full indication

For the treatment of adults and children with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. Insulin lispro Sanofi is also indicated for the initial stabilisation of diabetes mellitus.

Evidence ↗

Contains information from the European Medicines Agency (European Medicines Agency), © EMA, reused under CC BY 4.0.

Clinical trials

135 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
135
registered trials across all phases
LATEST COMPLETION 2025
5
Active studies
4
Recruiting
72
Late-stage (III+)
108
Completed
22
Discontinued
PHASE DISTRIBUTIONn = 135
Phase 146Phase 1 / 22Phase 215Phase 2 / 31Phase 335Phase 423Phase N / A13

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

5 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20092024
Most influential
Recent papers
Major research themes8
Insulin Lispro2Blood Glucose1Cross-Over Studies1Diabetes Mellitus, Type 11Hyaluronoglucosaminidase1Hypoglycemic Agents1Insulin Aspart1Postprandial Period1
Journals, researchers & institutions
Top journals
  • Diabetes technology & therapeutics5
Leading researchers
  • Muchmore DB3
  • Vaughn DE3
  • Hompesch M2
  • Morrow L2
  • Allen JM1
  • Bailey TS1
  • Bally L1
  • Bilinsky IP1
Leading institutions
free-text, unnormalised
  • Profil Institute for Clinical Research2
  • 1 Institut für Klinische Forschung und Entwicklung (IKFE) Berlin GmbH1
  • 2 AMCR Institute1
  • Bern University Hospital1
  • Cambridge University Hospitals NHS Foundation Trust1
  • Endocrinology and Metabolism Centre1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Acts on the same molecular target as Insulin Lispro, with an overlapping disease area.

Shared target1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.