Drug

Isoflurane

In clinical development

ClassGABA-A receptor; anion channel positive allosteric modulatorEmerging researchLate-stage development

Also known as Fluriso, Forane, IsoSol, Isospire+4 more

Fluriso, Forane, IsoSol, Isospire, Terrell, Isoflurano, 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, Isofluranum.

RxNorm6026 ChEMBLCHEMBL1256 ATCN01AB06UNIICYS9AKD70P

Research papers

Active clinical trials

Protein targets

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

COMPARISON OF PROPOFOL INFUSION VS INHALATIONAL AGENT ISOFLURANE IN TERMS OF CONTROLLED HYPOTENSION IN PATIENTS UNDERGOING ENDOSCOPIC SINUS SURGERY

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

Inhaled Sedation in Critically Ill Patients: a Multicentre Randomized Clinical Trial

Clinical trial2026-06-29Results expected Q1 2027 · ClinicalTrials.gov

Evaluation of the Safety of Inhaled Sedation With Isoflurane in Patients With Severe Traumatic Brain Injury

Clinical trial2026-06-20Primary completion · ClinicalTrials.gov

Effect of Volatile Sedation on Spontaneous Breathing During Mechanical Ventilation for Patients With the Acute Respiratory Distress Syndrome

Clinical trial2026-06-04Results expected Q3 2027 · ClinicalTrials.gov

A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)

Clinical trial2026-03-24Results posted · ClinicalTrials.gov

Desflurane Versus Isoflurane for Speeding Postanesthetic Recovery and Hospital Discharge: a Cluster Randomized Crossover Trial

Clinical trial2026-03-02Withdrawn · ClinicalTrials.gov

A Comparative Study Between the Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy

Clinical trial2026-03-01Primary completion · ClinicalTrials.gov

Sevoflurane/Dexmedetomidine vs. Isoflurane and Their Effects on Pediatric Emergence Delirium

Clinical trial2025-12-16Results expected Q4 2026 · ClinicalTrials.gov

A Randomised Active-controlled Study to Compare Efficacy & Safety of Inhaled Isoflurane Delivered by the AnaConDa-S (Anaesthetic Conserving Device) vs IV Midazolam for Sedation in Mechanically Ventilated Paediatric Patients 3-17 Years Old

Clinical trial2025-05-25Results posted · ClinicalTrials.gov

Effect of Inhalational Anesthetics on Myocardial Deformation Indices - A Dose-Response Cross-over Study

Clinical trial2023-05-04Completed · ClinicalTrials.gov

Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.

Research2003-02-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Isoflurane

Aliases & brands

FlurisoForaneIsoSolIsospireTerrellIsoflurano1-chloro-2,2,2-trifluoroethyl difluoromethyl etherIsofluranum

RxNorm CUI

6026

ChEMBL ID

CHEMBL1256

ATC codes

N01AB06

UNII

CYS9AKD70P

Primary mechanism

GABA-A receptor; anion channel positive allosteric modulator

Pharmacology & targets

23 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

Gamma-aminobutyric acid receptor subunit alpha-1

GABRA1 · P14867