Drug

Ketorolac

In clinical development

Emerging researchLate-stage development

Also known as Acular, Acuvail, Ketorolac Tromethamine, Omidria+5 more

Acular, Acuvail, Ketorolac Tromethamine, Omidria, Sprix, Toradol, rac-Ketorolac, Ketorolaco, Ketorolacum.

RxNorm35827 ChEMBLCHEMBL469UNIIYZI5105V0L

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Effects of Paracervical Block With Combined Ketorolac and Lidocaine on Perceived Pain in Osmotic Dilator Placement for Abortion, a Randomized Controlled Trial

Clinical trial2026-07-06Results expected Q2 2027 · ClinicalTrials.gov

Postoperative Pain Outcomes After Use of Bupivacaine-Meloxicam Extended-Release Solution in Robot Assisted Total Knee Arthroplasty: A Prospective Study

Clinical trial2026-07-06Results expected Q1 2028 · ClinicalTrials.gov

A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis

Clinical trial2026-07-01Withdrawn · ClinicalTrials.gov

Efficacy of Ketorolac for Postoperative Pain Management in Hip Arthroscopy: A Prospective, Randomized, Clinical Trial

Clinical trial2026-06-30Results expected Q3 2026 · ClinicalTrials.gov

Timing of Oral Ketorolac for Pain Reduction in IUD Insertion: A Double-Blind Randomized Controlled Trial

Clinical trial2026-06-30Primary completion · ClinicalTrials.gov

Study on Ketorolac for Improving Outcomes and Prognosis in Patients With Stanford Type A Aortic Dissection -A Single-Center, Randomized, Double-Blind, Controlled Clinical Trial

Clinical trial2026-06-23Results expected Q3 2027 · ClinicalTrials.gov

Preeclampsia And Nonsteroidal Drugs for Analgesia (PANDA): a Randomized Non Inferiority Trial

Clinical trial2026-06-15Completed · ClinicalTrials.gov

Non-Narcotic Pain Control After ACL Reconstruction

Clinical trial2026-06-12Primary completion · ClinicalTrials.gov

A Prospective, Randomized, Double-Blind, Non-Inferiority Trial Comparing Intramuscular Fentanyl and Ketorolac With Nerve of Arnold Block for Postoperative Pain Management in Pediatric Patients Undergoing Bilateral Myringotomy With Tympanostomy Tube Placement

Clinical trial2026-06-01Primary completion · ClinicalTrials.gov

Ultrasound Guided Sacroiliac Joint Injections With Ketorolac Versus Corticosteroid: A Prospective Non-inferiority Study

Clinical trial2026-06-01Primary completion · ClinicalTrials.gov

Does Scheduled Low-Dose Short-Term NSAID (Ketorolac) Modulate Cytokine Levels After Orthopaedic Polytrauma? A Secondary Analysis of a Randomized Clinical Trial.

Research2024-07-01Journal of orthopaedic trauma

Low-Dose Short-Term Scheduled Ketorolac Reduces Opioid Use and Pain in Orthopaedic Polytrauma Patients: A Randomized Clinical Trial.

Research2023-12-01Journal of orthopaedic trauma

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Ketorolac

Aliases & brands

AcularAcuvailKetorolac TromethamineOmidriaSprixToradolrac-KetorolacKetorolacoKetorolacum

RxNorm CUI

35827

ChEMBL ID

CHEMBL469

UNII

YZI5105V0L

Clinical trials

195 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

195

registered trials across all phases

LATEST COMPLETION 2026

Active studies

Recruiting

150

Late-stage (III+)

109

Completed

Discontinued

PHASE DISTRIBUTIONn = 195

Early Phase 17Phase 110Phase 1 / 22Phase 226Phase 2 / 37Phase 329Phase 486Phase N / A28

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Efficacy of Methylprednisolone for Pain Control After ACL Repair: A Randomized Controlled Trial

RecruitingPH IVSt. Louis Universityn=902031

Effectiveness of Corticosteroid vs Ketorolac Shoulder Injections: a Prospective Double-Blinded Randomized Trial

WithdrawnPH IVMichael Khazzam2028

Balancing Comfort and Success: Post-retrieval Ketorolac in Fresh Embryo Transfers

RecruitingPH IVJessica D. Kresowikn=2002028

Postoperative Pain Outcomes After Use of Bupivacaine-Meloxicam Extended-Release Solution in Robot Assisted Total Knee Arthroplasty: A Prospective Study

Not yet recruitingPH IVAllegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)n=1502028

Ketorolac Dosing for Acute Vaso-Occlusive Crisis in Pediatric Patients With Sickle Cell Disease

Not yet recruitingPH IVChildren's Blood and Cancer Center at Dell Children's Medical Centern=1022028

Recent completions

Trials that read out recently, adding to the completed evidence base.

Preeclampsia And Nonsteroidal Drugs for Analgesia (PANDA): a Randomized Non Inferiority Trial

CompletedPH IIWashington University School of Medicinen=2872026

Comparison of Two Dosing Regimens of Intravenous Ketorolac for Post-Cesarean Pain Control: A Randomized Controlled Trial

CompletedN/ACairo Universityn=1252026

Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery; a Randomized, Controlled, Non-inferiority Study

CompletedN/ABoston Children's Hospitaln=622026

Comparison Between Intra-Operative Pectoral Block and Intravenous Analgesia for Post-Operative Pain Relief in Patients Undergoing Modified Radical Mastectomy

CompletedPH IIIIslamabad Medical and Dental Collegen=602025

The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral Total Knee Arthroplasty: a Randomized Controlled Trial

CompletedN/ADamascus Universityn=802025

Post ERCP Pancreatitis Prophylaxis, Effectiveness of Rectal Indomethacin vs Intravenous Ketorolac in the Pediatric Population

CompletedPH IVDavid Vitale MDn=1922025

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20232024

Most influential

Low-Dose Short-Term Scheduled Ketorolac Reduces Opioid Use and Pain in Orthopaedic Polytrauma Patients: A Randomized Clinical Trial.

Journal of orthopaedic trauma · 2023 · 1 cites