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Drug

Ketorolac

Established medicine
ResearchOngoing clinical research
Also known as Acular, Acuvail, Ketorolac Tromethamine, Omidria+5 more

Acular, Acuvail, Ketorolac Tromethamine, Omidria, Sprix, Toradol, rac-Ketorolac, Ketorolaco, Ketorolacum.

RxNorm35827ChEMBLCHEMBL469ATCS01BC05ATCM01AB15UNIIYZI5105V0L
2
Research papers
27
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Combined Ketorolac and Lidocaine Paracervical Block for Office Hysteroscopy: a Randomized Controlled Trial

Clinical trial2026-09-01Primary completion · ClinicalTrials.gov

Efficacy of Ketorolac for Postoperative Pain Management in Hip Arthroscopy: A Prospective, Randomized, Clinical Trial

Clinical trial2026-09-01Primary completion · ClinicalTrials.gov

Evaluation of the Effects of Ketorolac 15mg IV Versus 30mg IV on Duration of Analgesia in Patients Who Present to the Emergency Department With Renal Colic

Clinical trial2026-09-01Primary completion · ClinicalTrials.gov

Safety of Ketorolac in Primary Total Hip Arthroplasties: An Analysis of Over 7,000 Cases

Industry2026-07-27The Journal of Arthroplasty

Efficacy of Ropivacaine Epinephrine Clonidine Ketorolac (R.E.C.K) vs Exparel in Robotic Nephrectomy: a Randomized, Prospective Trial

Clinical trial2026-07-13Results expected Q4 2027 · ClinicalTrials.gov

Effects of Paracervical Block With Combined Ketorolac and Lidocaine on Perceived Pain in Osmotic Dilator Placement for Abortion, a Randomized Controlled Trial

Clinical trial2026-07-06Results expected Q2 2027 · ClinicalTrials.gov

Postoperative Pain Outcomes After Use of Bupivacaine-Meloxicam Extended-Release Solution in Robot Assisted Total Knee Arthroplasty: A Prospective Study

Clinical trial2026-07-06Results expected Q1 2028 · ClinicalTrials.gov

A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis

Clinical trial2026-07-01Withdrawn · ClinicalTrials.gov

Timing of Oral Ketorolac for Pain Reduction in IUD Insertion: A Double-Blind Randomized Controlled Trial

Clinical trial2026-06-30Primary completion · ClinicalTrials.gov

Study on Ketorolac for Improving Outcomes and Prognosis in Patients With Stanford Type A Aortic Dissection -A Single-Center, Randomized, Double-Blind, Controlled Clinical Trial

Clinical trial2026-06-23Results expected Q3 2027 · ClinicalTrials.gov

Does Scheduled Low-Dose Short-Term NSAID (Ketorolac) Modulate Cytokine Levels After Orthopaedic Polytrauma? A Secondary Analysis of a Randomized Clinical Trial.

Research2024-07-01Journal of orthopaedic trauma

Low-Dose Short-Term Scheduled Ketorolac Reduces Opioid Use and Pain in Orthopaedic Polytrauma Patients: A Randomized Clinical Trial.

Research2023-12-01Journal of orthopaedic trauma

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Ketorolac
Aliases & brands
AcularAcuvailKetorolac TromethamineOmidriaSprixToradolrac-KetorolacKetorolacoKetorolacum
RxNorm CUI
35827
ChEMBL ID
CHEMBL469
ATC codes
S01BC05M01AB15
UNII
YZI5105V0L

Clinical trials

196 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
196
registered trials across all phases
LATEST COMPLETION 2026
27
Active studies
25
Recruiting
151
Late-stage (III+)
110
Completed
59
Discontinued
PHASE DISTRIBUTIONn = 196
Early Phase 17Phase 110Phase 1 / 22Phase 226Phase 2 / 37Phase 329Phase 487Phase N / A28

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Efficacy of Methylprednisolone for Pain Control After ACL Repair: A Randomized Controlled Trial

RecruitingPH IVSt. Louis Universityn=902031

Effectiveness of Corticosteroid vs Ketorolac Shoulder Injections: a Prospective Double-Blinded Randomized Trial

WithdrawnPH IVMichael Khazzam2028

Balancing Comfort and Success: Post-retrieval Ketorolac in Fresh Embryo Transfers

RecruitingPH IVJessica D. Kresowikn=2002028

Postoperative Pain Outcomes After Use of Bupivacaine-Meloxicam Extended-Release Solution in Robot Assisted Total Knee Arthroplasty: A Prospective Study

Not yet recruitingPH IVAllegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)n=1502028

Ketorolac Dosing for Acute Vaso-Occlusive Crisis in Pediatric Patients With Sickle Cell Disease

Not yet recruitingPH IVChildren's Blood and Cancer Center at Dell Children's Medical Centern=1022028

Recent completions

Trials that read out recently, adding to the completed evidence base.

Preeclampsia And Nonsteroidal Drugs for Analgesia (PANDA): a Randomized Non Inferiority Trial

CompletedPH IIWashington University School of Medicinen=2872026

Comparison of Two Dosing Regimens of Intravenous Ketorolac for Post-Cesarean Pain Control: A Randomized Controlled Trial

CompletedN/ACairo Universityn=1252026

Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery; a Randomized, Controlled, Non-inferiority Study

CompletedN/ABoston Children's Hospitaln=622026

Comparison Between Intra-Operative Pectoral Block and Intravenous Analgesia for Post-Operative Pain Relief in Patients Undergoing Modified Radical Mastectomy

CompletedPH IIIIslamabad Medical and Dental Collegen=602025

The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral Total Knee Arthroplasty: a Randomized Controlled Trial

CompletedN/ADamascus Universityn=802025

Post ERCP Pancreatitis Prophylaxis, Effectiveness of Rectal Indomethacin vs Intravenous Ketorolac in the Pediatric Population

CompletedPH IVDavid Vitale MDn=1922025

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20232024
Major research themes4
Anti-Inflammatory Agents, Non-Steroidal1Cytokines1Ketorolac1Multiple Trauma1
Journals, researchers & institutions
Top journals
  • Journal of orthopaedic trauma2
Leading researchers
  • Aneja A2
  • Bernard AC2
  • Foster JA2
  • Griffin JT2
  • Hawk GS2
  • Landy DC2
  • Oyler DR2
  • Borgida JS1
Leading institutions
free-text, unnormalised
  • University of Kentucky2
  • Massachusetts General Hospital1
  • OrthoVirginia and Liberty University1
  • US Army Institute of Surgical Research1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials