Drug

Lidocaine

In clinical development

Emerging researchLate-stage developmentCooling momentum

Also known as 2-(Diethylamino)-2',6'-acetoxylidide, Abreva Rapid Pain Relief, Akten, Allercaine+113 more

2-(Diethylamino)-2',6'-acetoxylidide, Abreva Rapid Pain Relief, Akten, Allercaine, Alocane, Alocane Max Strength, Alocane Plus, Ana-Lex, AnaMantle HC, AneCream, AneCream 5, Anestacaine, Anestacon, Bactine, Bactine Antibiotic, Band-Aid Hurt-Free, Bio-Kool, Bruselix, Burn Jel Plus, Cicloferon, CidalEaze, Comfortcaine, Cutiecaine, D-Caine, Decadron with Xylocaine, Derma Numb, Dermaflex, Dilocaine, Doloracin with Lidocaine, Dr. Numb, Ela-Max, Emla, Flavalta, Glydo, Hexa-Caine, Hydrocortisone-Lidocaine, Keepan, Kool-Down, L-Caine, LMX, Lenzagel, Lenzapatch, LidaMantle, LidaMantle HC, Lido King, LidoPatch, LidoPro, LidoPro Pain Relieving Patch, LidoPro Patch, Lidocaine and Tetracaine, Lidocaine, Topical, Lidocaine-Menthol, Lidocaine-Prilocaine, Lidocaine-Tetracaine, Lidocort, Lidocream, Lidoderm, Lidoguard, Lidoguard Pain Relief, Lidomar, Lidostat, Lidotral, Lidotran, Lidozen, Lidum, Lignocaine, Lignospan, Lipocaine, Lydexa, Medi-Derm with Lidocaine, Mercuroclear, Nervocaine, Oraqix, Pliaglis, Puroxcin, RadiaGuard, RectiCare, RectiCare Advance Cream, Recticare Wipes, Regenecare, Relador, Senatec, Senatec HC, Solarcaine, Sonacaine, StaphAseptic, Synera, Tecnu First Aid, Terramycin IM, Topicaine, Topicaine Ultra, Tranzarel, Tridacaine, Trifena, Truxacaine, Uber Numb, Unburn, Unguentine Plus, Vagisil, Workvie, Xolido, Xylocaine, Xylocaine with Epinephrine, ZTlido, Zcaine, Zensa, Zingo, Zionodil, zilactin-L, Lidocaina, Lidocaine 3%, Lidocan, Lidocare, 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide, Lidocaine Hydrochloride, Lidocainum, alpha-diethylamino-2,6-dimethylacetanilide.

RxNorm6387 ChEMBLCHEMBL79UNII98PI200987

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Comprasion of Intravenous Nalbuphine Versus Lidocaine in Reducing Propofol -Induced Injection Pain During General Surgery Procedure

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

Intra-arterial Lidocaine and Methylprednisolone Injection Into the Middle Meningeal Artery For Treatment of Headache Associated With Subarachnoid Hemorrhage

Clinical trial2026-07-08Results expected Q1 2027 · ClinicalTrials.gov

Optimizing Patient-centred Outcomes Using Opioid Minimization Strategies (OPUS) Anesthesia: a Pilot Randomised Controlled Trial

Clinical trial2026-07-01Results expected Q2 2027 · ClinicalTrials.gov

Phase III, Randomized, Double-blind Study to Assess the Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Analgesic Morphine Rachi Anesthesia for Major Digestive or Abdominal Surgery by Laparotomy.

Clinical trial2026-07-01Results expected Q3 2027 · ClinicalTrials.gov

Intravenous Lidocaine Infusion Versus Placebo, for Post Operative Acute Pain Control in Patients Undergoing Staging Laparoscopy

Clinical trial2026-06-30Primary completion · ClinicalTrials.gov

Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo

Clinical trial2026-06-23Results posted · ClinicalTrials.gov

Comparison of Intravenous Dexmedetomidine and Lignocaine in Reducing Hemodynamic Responses During Laryngoscopy and Endotracheal Intubation In Patients Undergoing Cardiac Surgery at Rawalpindi Institute Of Cardiology- A Randomized Controlled Trial

Clinical trial2026-05-28Results expected Q3 2026 · ClinicalTrials.gov

Evaluation of the Analgesia by Serratus Plane Block During Pleural Drainage in Intensive Care Unit.

Clinical trial2026-05-13Results expected Q3 2026 · ClinicalTrials.gov

Buffered Versus Non-Buffered Lidocaine With Epinephrine for Mandibular Nerve Block: Clinical Outcomes.

Research2016-10-08Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Lidocaine analgesia for removal of wound vacuum-assisted closure dressings: a randomized double-blinded placebo-controlled trial.

Research2013-02-01Journal of orthopaedic trauma

A randomized double-blind study comparing intradermal anesthetic tolerability, efficacy, and cost-effectiveness of lidocaine, buffered lidocaine, and bacteriostatic normal saline for peripheral intravenous insertion.

Research2012-03-01Journal of infusion nursing : the official publication of the Infusion Nurses Society

A comparison of the pain perceived during intravenous catheter insertion after injection with various local anesthetics.

Research2011-08-01AANA journal

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Lidocaine

Aliases & brands

2-(Diethylamino)-2',6'-acetoxylidideAbreva Rapid Pain ReliefAktenAllercaineAlocaneAlocane Max StrengthAlocane PlusAna-LexAnaMantle HCAneCreamAneCream 5AnestacaineAnestaconBactineBactine AntibioticBand-Aid Hurt-FreeBio-KoolBruselixBurn Jel PlusCicloferonCidalEazeComfortcaineCutiecaineD-CaineDecadron with XylocaineDerma NumbDermaflexDilocaineDoloracin with LidocaineDr. NumbEla-MaxEmlaFlavaltaGlydoHexa-CaineHydrocortisone-LidocaineKeepanKool-DownL-CaineLMXLenzagelLenzapatchLidaMantleLidaMantle HCLido KingLidoPatchLidoProLidoPro Pain Relieving PatchLidoPro PatchLidocaine and TetracaineLidocaine, TopicalLidocaine-MentholLidocaine-PrilocaineLidocaine-TetracaineLidocortLidocreamLidodermLidoguardLidoguard Pain ReliefLidomarLidostatLidotralLidotranLidozenLidumLignocaineLignospanLipocaineLydexaMedi-Derm with LidocaineMercuroclearNervocaineOraqixPliaglisPuroxcinRadiaGuardRectiCareRectiCare Advance CreamRecticare WipesRegenecareReladorSenatecSenatec HCSolarcaineSonacaineStaphAsepticSyneraTecnu First AidTerramycin IMTopicaineTopicaine UltraTranzarelTridacaineTrifenaTruxacaineUber NumbUnburnUnguentine PlusVagisilWorkvieXolidoXylocaineXylocaine with EpinephrineZTlidoZcaineZensaZingoZionodilzilactin-LLidocainaLidocaine 3%LidocanLidocare2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamideLidocaine HydrochlorideLidocainumalpha-diethylamino-2,6-dimethylacetanilide

RxNorm CUI

6387

ChEMBL ID

CHEMBL79

UNII

98PI200987