How strongly the incorporated evidence supports specific clinical claims about this treatment. A confidence figure is a current summary of evidence strength, not a permanent verdict.

Lowers systolic blood pressure in hypertension

66%Moderate confidence

Uncertainty ±15%Evidence coverage: MinimalUpdated 31 October 2025

High point estimate, but substantial uncertainty remains.

Confidence has a moderate point estimate but a wide uncertainty band — the evidence base is still thin.

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Losartan

Aliases & brands

ArbliCozaarHyzaarHydrochlorothiazide-LosartanLosartan Potassium

RxNorm CUI

52175

ChEMBL ID

CHEMBL191

UNII

JMS50MPO89

Clinical trials

193 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

193

registered trials across all phases

LATEST COMPLETION 2026

Active studies

Recruiting

119

Late-stage (III+)

113

Completed

Discontinued

PHASE DISTRIBUTIONn = 193

Early Phase 110Phase 119Phase 1 / 27Phase 238Phase 2 / 35Phase 337Phase 442Phase N / A35

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Effect of Losartan on the Neurohumoral Axis and Ventricular Remodeling of Patients With Severe Aortic Regurgitation Undergoing Valve Surgery

RecruitingPH IVVitor Emer Egypto Rosan=602029

Oral Losartan to Decrease the Risk of Postoperative Arthrofibrosis Following Primary and Revision Anterior Cruciate Ligament Reconstruction

Not yet recruitingPH IVRush University Medical Centern=1442028

Occult Cardiovascular Disease With Chronic Exposure to Secondhand Tobacco Smoke

RecruitingPH IVUniversity of California, San Franciscon=1002026

A Multi-center, Randomized, Open-label, Active Comparator-controlled, Phase 4 Clinical Trial To Evaluate the Efficacy and Safety of Telmisartan Compared With Losartan in Patients With Diabetic Nephropathy and Hypertension

Unknown statusPH IVChong Kun Dang Pharmaceuticaln=982025

Losartan Use to Mitigate Arthrofibrosis Following Total Join Arthroplasty

WithdrawnPH IVNYU Langone Health2024

Recent completions

Trials that read out recently, adding to the completed evidence base.

Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease: A Prospective, Phase II Study.

CompletedPH IIChildren's Hospital Medical Center, Cincinnatin=142026

Anti-Inflammatory Therapy to Augment CFTR Rescue in CF Patients

CompletedPH IUniversity of Kansas Medical Centern=132026

SHAPER: A Phase 1 Study of Losartan and Hypofractionated Radiation Therapy After Induction Chemotherapy for Borderline Resectable or Locally Advanced Pancreatic Cancer

CompletedPH IUniversity of Utahn=222026

The Role of Losartan in the Prevention of Early Structural Changes Associated With Radiation-Induced Heart Failure

CompletedPH IMassachusetts General Hospitaln=52025

Efficacy of Losartan in the Prevention of Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients.

CompletedPH IIFuture University in Egyptn=842025

ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension

CompletedPH IIUniversity of Alabama at Birminghamn=2232024

Research activity

8 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20102021

Most influential

Effect of losartan on prevention and progression of early diabetic nephropathy in American Indians with type 2 diabetes.

Diabetes · 2013 · 90 cites

A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19.

EClinicalMedicine · 2021 · 54 cites

Losartan for the nephropathy of sickle cell anemia: A phase-2, multicenter trial.

American journal of hematology · 2017 · 38 cites

Effect of angiotensin receptor blockade on insulin sensitivity and endothelial function in abdominally obese hypertensive patients with impaired fasting glucose.

Clinical science (London, England : 1979) · 2012 · 23 cites

Effects of losartan and allopurinol on cardiorespiratory regulation in obstructive sleep apnoea.

Experimental physiology · 2018 · 14 cites

A randomized, open-label, dose-response study of losartan in hypertensive children.

Clinical journal of the American Society of Nephrology : CJASN · 2014 · 14 cites