Drug

Methamphetamine

In clinical development

Emerging researchLate-stage development

Also known as Desoxyephedrine, Desoxyn, Metamfetaminum, Metanfetamina+9 more

Desoxyephedrine, Desoxyn, Metamfetaminum, Metanfetamina, d-1-phenyl-2-methylaminopropane, d-N-methylamphetamine, d-deoxyephedrine, d-desoxyephedrine, d-phenylisopropylmethylamine, Metamfetamine, Métamfétamine, Methamphetamine Hydrochloride, Methamphetaminum.

RxNorm6816 ChEMBLCHEMBL1201201 ATCN06BA03UNII44RAL3456C

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Phase 2 Single-Dose Study to Evaluate Safety and Efficacy of CS-1103 in Participants With Methamphetamine Use Disorder Not Seeking Treatment Receiving a Single Dose of Methamphetamine

Clinical trial2026-07-07Results expected Q3 2026 · ClinicalTrials.gov

Advancing Troiluzole as a Treatment for Methamphetamine Use Disorder: A Human Laboratory Study

Clinical trial2026-06-08Results expected Q1 2029 · ClinicalTrials.gov

Short-term Effects of Methamphetamine on Residual Latent HIV Disease (EMRLHD) Study

Clinical trial2026-05-13Results expected Q3 2029 · ClinicalTrials.gov

Short-term Effects of Methamphetamine Exposure on Residual Viral Transcription During Treated HIV Disease

Clinical trial2026-04-09Results posted · ClinicalTrials.gov

MDMA-Assisted Cognitive Behavioral Therapy (CBT) Compared With Methamphetamine-Assisted CBT in Obsessive-Compulsive Disorder (OCD): A Phase II Study

Clinical trial2026-03-05Results expected Q4 2026 · ClinicalTrials.gov

Drugs Brain and Behavior

Clinical trial2025-01-09Results posted · ClinicalTrials.gov

Effects of Genotype on Resting State Connectivity During Methamphetamine Administration

Clinical trial2024-11-15Results posted · ClinicalTrials.gov

Melatonin Regulates Neuronal Synaptic Plasticity in the Supramammillary Nucleus and Attenuates Methamphetamine-Induced Conditioned Place Preference and Sensitization in Mice.

Research2024-09-01Journal of pineal research

Phase 1 Safety-interaction Study of Mirtazapine for the Treatment of Methamphetamine Use Disorder

Clinical trial2024-05-31Completed · ClinicalTrials.gov

Effect of Stimulant Drugs on Social Perception

Clinical trial2024-01-05Results posted · ClinicalTrials.gov

Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function

Clinical trial2023-10-24Completed · ClinicalTrials.gov

Drug Effects on EEG

Clinical trial2023-04-01Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Methamphetamine

Aliases & brands

DesoxyephedrineDesoxynMetamfetaminumMetanfetaminad-1-phenyl-2-methylaminopropaned-N-methylamphetamined-deoxyephedrined-desoxyephedrined-phenylisopropylmethylamineMetamfetamineMétamfétamineMethamphetamine HydrochlorideMethamphetaminum

RxNorm CUI

6816

ChEMBL ID

CHEMBL1201201

ATC codes

N06BA03

UNII

44RAL3456C

Clinical trials

17 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2024

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 17

Early Phase 16Phase 15Phase 22Phase 43Phase N / A1

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Short-term Effects of Methamphetamine on Residual Latent HIV Disease (EMRLHD) Study

Not yet recruitingPH IVUniversity of California, San Franciscon=202030

Effects of Genotype on Resting State Connectivity During Methamphetamine Administration

CompletedPH IVOregon Health and Science Universityn=692023

Short-term Effects of Methamphetamine Exposure on Residual Viral Transcription During Treated HIV Disease

CompletedPH IVUniversity of California, San Franciscon=142023

Recent completions

Trials that read out recently, adding to the completed evidence base.

Drugs Brain and Behavior

CompletedPH IUniversity of Chicagon=1382024

Phase 1 Safety-interaction Study of Mirtazapine for the Treatment of Methamphetamine Use Disorder

CompletedPH ISan Francisco Department of Public Healthn=152024

Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function

CompletedPH IUniversity of Chicagon=432023

Drug Effects on EEG

CompletedPH IUniversity of Chicagon=402023

Effects of Genotype on Resting State Connectivity During Methamphetamine Administration

CompletedPH IVOregon Health and Science Universityn=692023

Short-term Effects of Methamphetamine Exposure on Residual Viral Transcription During Treated HIV Disease

CompletedPH IVUniversity of California, San Franciscon=142023

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Melatonin Regulates Neuronal Synaptic Plasticity in the Supramammillary Nucleus and Attenuates Methamphetamine-Induced Conditioned Place Preference and Sensitization in Mice.

Journal of pineal research · 2024 · 7 cites

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Melatonin

Frequently co-studied with Methamphetamine in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials