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Drug

Methylene blue

Established medicine
ClassSoluble guanylate cyclase inhibitorResearchOngoing clinical research
Also known as Atrosept, Azul de metileno, Basic Blue 9, C.I. basic blue 9+50 more

Atrosept, Azul de metileno, Basic Blue 9, C.I. basic blue 9, Chlorure de méthylthioninium, Cloruro de metiltioninio, Cystemms-V, Darcalma, Darpaz, Dolsed, Hyolev MB, Hyophen, Lowacryl blue 9, MHP-A, MSP-Blu, Methylene blue stain, Methylenium ceruleum, Methylthioninii chloridum, Phosphasal, Prosed DS, Provayblue, Solvent blue 8, Swiss blue, Trac Tabs 2x, UAA, UTICAP, Uramit MB, Urapine, Urelle, Uretron, Uretron DS, Uri-Sep SC, Uribel, Uribel Tabs, Uridon Modified, Urimar Reformulated Oct 2013, Urimar T, Urimax, Urin DS, Urised, Uritin, Uro-Blue, Urogesic Blue Reformulated Apr 2012, Urogesic-Blue, Urolene Blue, Urolet MB, Usept, Ustell, Utira, Utrona-C, Methylthioninium chloride, Methylthioninium chloride stain, Prosed/DS, Urin D/S.

8
Active clinical trials
4
Protein targets
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Adjunctive Methylene BLUe in Septic SHock: a Pilot Randomized Controlled Trial

Clinical trial2026-03-06Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Methylene blue
Aliases & brands
AtroseptAzul de metilenoBasic Blue 9C.I. basic blue 9Chlorure de méthylthioniniumCloruro de metiltioninioCystemms-VDarcalmaDarpazDolsedHyolev MBHyophenLowacryl blue 9MHP-AMSP-BluMethylene blue stainMethylenium ceruleumMethylthioninii chloridumPhosphasalProsed DSProvayblueSolvent blue 8Swiss blueTrac Tabs 2xUAAUTICAPUramit MBUrapineUrelleUretronUretron DSUri-Sep SCUribelUribel TabsUridon ModifiedUrimar Reformulated Oct 2013Urimar TUrimaxUrin DSUrisedUritinUro-BlueUrogesic Blue Reformulated Apr 2012Urogesic-BlueUrolene BlueUrolet MBUseptUstellUtiraUtrona-CMethylthioninium chlorideMethylthioninium chloride stainProsed/DSUrin D/S
RxNorm CUI
6878
ChEMBL ID
CHEMBL405110
ATC codes
V04CG05V03AB17
UNII
8NAP7826UB
Primary mechanism
Soluble guanylate cyclase inhibitor

Pharmacology & targets

4 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

INHIBITORSoluble guanylate cyclase inhibitor
INHIBITORSoluble guanylate cyclase inhibitor
INHIBITORSoluble guanylate cyclase inhibitor
INHIBITORSoluble guanylate cyclase inhibitor

Clinical trials

60 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
60
registered trials across all phases
LATEST COMPLETION 2026
8
Active studies
8
Recruiting
33
Late-stage (III+)
35
Completed
17
Discontinued
PHASE DISTRIBUTIONn = 60
Early Phase 13Phase 15Phase 219Phase 2 / 35Phase 36Phase 46Phase N / A16

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • ClinicalTrials.gov — clinical trials