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Drug

Methylprednisolone

Approved · FDA
ClassGlucocorticoid receptor agonistEmerging researchLate-stage development
Also known as A-Methapred, DEPO-Medrol, HybriSil, Medrol+7 more

A-Methapred, DEPO-Medrol, HybriSil, Medrol, SOLU-Medrol, delta(1)-6alpha-Methylhydrocortisone, Methylprednisolon, Metilprednisolona, MethylPREDNISolone Acetate, MethylPREDNISolone Sodium Succinate, Methylprednisolonum.

RxNorm6902ChEMBLCHEMBL650ATCH02BX01ATCD07AA01ATCD10AA02ATCH02AB04UNIIX4W7ZR7023
2
Research papers
41
Active clinical trials
Glucocorticoid receptor
Primary target
12
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Randomized, Open-Label, Multicenter, Phase 3 Study of Zilovertamab Vedotin (MK-2140) in Combination With R-CHP Versus R-CHOP in Participants With Previously Untreated Diffuse Large B-Cell Lymphoma (DLBCL) (waveLINE-010)

Clinical trial2026-07-16Results expected Q3 2029 · ClinicalTrials.gov

A Randomized Phase II Study Testing the Combination of Inotuzumab Ozogamicin and Lower Dose Chemotherapy Plus Blinatumomab Compared to Usual Chemotherapy Plus Blinatumomab for Older Adults With B-Cell Acute Lymphoblastic Leukemia or B-Cell Lymphoblastic Lymphoma

Clinical trial2026-07-10Results expected Q2 2027 · ClinicalTrials.gov

A Phase 2 Study of Blinatumomab in Combination With Chemotherapy for Infants With Newly Diagnosed Acute Lymphoblastic Leukemia With Randomization of KMT2A-Rearranged Patients to Addition of Venetoclax

Clinical trial2026-07-09Results expected Q4 2028 · ClinicalTrials.gov

An Oral Methylprednisolone Taper Within a Multimodal Analgesic Regimen After Total Knee Arthroplasty: a Double-Blind Randomized Placebo-Controlled Trial

Clinical trial2026-07-09Results expected Q2 2027 · ClinicalTrials.gov

Intra-arterial Lidocaine and Methylprednisolone Injection Into the Middle Meningeal Artery For Treatment of Headache Associated With Subarachnoid Hemorrhage

Clinical trial2026-07-08Results expected Q1 2027 · ClinicalTrials.gov

A Randomized Controlled Trial of Methylprednisolone Versus Standard of Care in Patients Undergoing Major Hepatectomy

Clinical trial2026-07-07Results expected Q1 2029 · ClinicalTrials.gov

Label change: METHYLPREDNISOLONE (ANDA207549)

Regulatory2026-06-25FDA

Label change: METHYLPREDNISOLONE (ANDA210985)

Regulatory2026-06-11FDA

Label change: METHYLPREDNISOLONE (ANDA210985)

Regulatory2024-12-20FDA

Label change: METHYLPREDNISOLONE (ANDA210985)

Regulatory2024-12-20FDA

High-dose intravenous methylprednisolone for hantavirus cardiopulmonary syndrome in Chile: a double-blind, randomized controlled clinical trial.

Research2013-06-19Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome.

Research2004-04-01Clinical and experimental immunology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Methylprednisolone
Aliases & brands
A-MethapredDEPO-MedrolHybriSilMedrolSOLU-Medroldelta(1)-6alpha-MethylhydrocortisoneMethylprednisolonMetilprednisolonaMethylPREDNISolone AcetateMethylPREDNISolone Sodium SuccinateMethylprednisolonum
RxNorm CUI
6902
ChEMBL ID
CHEMBL650
ATC codes
H02BX01D07AA01D10AA02H02AB04
UNII
X4W7ZR7023
Primary mechanism
Glucocorticoid receptor agonist
Regulatory jurisdictions
fda

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Glucocorticoid receptor
NR3C1 · P04150
AGONISTGlucocorticoid receptor agonist

Regulatory timeline

12 events

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
2016-11-09
Latest approval
2019-01-09
Authorities
FDA
Total events
12
fdaU.S. Food and Drug Administration· 12 events
2026-06-25Label change
Label change: METHYLPREDNISOLONE (ANDA207549)
Evidence ↗
2026-06-11Label change
Label change: METHYLPREDNISOLONE (ANDA210985)
Evidence ↗
2024-12-20Label change
Label change: METHYLPREDNISOLONE (ANDA210985)
Evidence ↗

Data from the U.S. Food and Drug Administration (U.S. Food and Drug Administration), public domain (CC0).

Clinical trials

194 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
194
registered trials across all phases
LATEST COMPLETION 2025
41
Active studies
33
Recruiting
106
Late-stage (III+)
102
Completed
51
Discontinued
PHASE DISTRIBUTIONn = 194
Early Phase 13Phase 113Phase 1 / 213Phase 259Phase 2 / 311Phase 336Phase 437Phase N / A22

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Comparison of the Effectiveness of Oral and Intratympanic Corticosteroid Treatments in Patients Diagnosed With Sudden Sensorineural Hearing Loss

RecruitingPH IVDr. Lutfi Kirdar Kartal Training and Research Hospitaln=2142028

An Oral Methylprednisolone Taper Within a Multimodal Analgesic Regimen After Total Knee Arthroplasty: a Double-Blind Randomized Placebo-Controlled Trial

RecruitingPH IVRush University Medical Centern=4202027

Effect of Methylprednisolone on Systemic Inflammatory Response and Clinical Parameters During Pediatric Congenital Open-Heart Surgery: A Randomized Controlled Trial

RecruitingPH IVAga Khan Universityn=602025

The Effect of Methylprednisolone Administration on the Reversal Time of Rocuronium by Sugammadex in the Pediatric Patient Group

CompletedPH IVKonya City Hospitaln=802025

Randomized, Double-blinded, Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections

Unknown statusPH IVUniversity of Manitoban=402024

Recent completions

Trials that read out recently, adding to the completed evidence base.

The Effect of Methylprednisolone Administration on the Reversal Time of Rocuronium by Sugammadex in the Pediatric Patient Group

CompletedPH IVKonya City Hospitaln=802025

Prospective Randomized Trial Using Medrol Dose Packs for Post-Operative Pain Control

CompletedPH IUniversity of Utahn=572024

A Phase III Study of Risk Directed Therapy for Infants With Acute Lymphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +/- FLT3 Inhibition (CEP-701, Lestaurtinib; NSC#617807)

CompletedPH IIIChildren's Oncology Groupn=2182024

Intracoronary Administration of Glucocorticoids as a Treatment Method for No-Reflow Phenomenon in STEMI Patients

CompletedPH IIAmosov National Institute of Cardiovascular Surgeryn=102024

A Phase 1, Three-Part, Open-Label, Parallel-Cohort Safety and Tolerability Study of Relugolix in Combination With Abiraterone Acetate Plus a Corticosteroid, Apalutamide, or Docetaxel With or Without Prednisone in Men With Metastatic Castration-Sensitive Prostate Cancer or Non-Metastatic or Metastatic Castration-Resistant Prostate Cancer

CompletedPH ISumitomo Pharma America, Inc.n=482024

Abatacept for Graft Versus Host Disease Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease: a Sickle Transplant Alliance for Research Trial

CompletedPH IMonica Bhatian=242023

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20042013
Most influential

Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome.

Clinical and experimental immunology · 2004 · 933 cites

High-dose intravenous methylprednisolone for hantavirus cardiopulmonary syndrome in Chile: a double-blind, randomized controlled clinical trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013 · 50 cites
Recent papers

High-dose intravenous methylprednisolone for hantavirus cardiopulmonary syndrome in Chile: a double-blind, randomized controlled clinical trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013 · 50 cites

Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome.

Clinical and experimental immunology · 2004 · 933 cites
Journals, researchers & institutions
Top journals
  • Clinical and experimental immunology1
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America1
Leading researchers
  • Belmar E1
  • Calvo M1
  • Castillo C1
  • Chan IH1
  • Chan MH1
  • Chung SS1
  • Cuiza A1
  • Díaz R1
Leading institutions
free-text, unnormalised
  • The Chinese University of Hong Kong1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.