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Drug

Metoprolol

In clinical development
Emerging researchLate-stage development
Also known as Betaloc, Dutoprol, Kapspargo, Lopresor+7 more

Betaloc, Dutoprol, Kapspargo, Lopresor, Lopressor, Lopressor HCT, Toprol, (RS)-Metoprolol, DL-metoprolol, Hydrochlorothiazide-Metoprolol, Metoprolol Tartrate.

RxNorm6918ChEMBLCHEMBL13ATCC07AB02UNIIGEB06NHM23
2
Research papers
8
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

An Investigator-Initiated Prospective Randomized Open-Label Blinded-Endpoint Crossover Trial Comparing the Effect and Safety of Flecainide and Metoprolol Versus Metoprolol Alone to Suppress Ventricular Arrhythmias in Arrhythmic Mitral Valve Prolapse

Clinical trial2026-06-01Primary completion · ClinicalTrials.gov

Dose-Response Interaction of Metoprolol and Sufentanil for Attenuating Hemodynamic Responses in Tracheal Intubation: Prospective Randomized Double-blind Study

Clinical trial2026-05-20Results expected Q2 2027 · ClinicalTrials.gov

Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes: A Hybrid Design in a Real-World Setting

Clinical trial2026-05-06Results expected Q2 2028 · ClinicalTrials.gov

An Open-label, Drug-drug Interaction Study to Investigate the Effects of Amlitelimab on the Pharmacokinetics of Selected Cytochrome P450 Substrates in Adult Participants With Moderate-to-severe Atopic Dermatitis

Clinical trial2026-04-02Completed · ClinicalTrials.gov

Use of Determination of Drug Levels to Optimize Pharmacotherapy of Heart Failure

Clinical trial2026-04-01Primary completion · ClinicalTrials.gov

Metoprolol to Reduce Perioperative Myocardial Injury

Clinical trial2026-01-28Results posted · ClinicalTrials.gov

Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA: a Randomised, Placebo-controlled, Mechanistic Study

Clinical trial2025-12-31Primary completion · ClinicalTrials.gov

Heart Rate Control: Betablockers or Ivabradine Therapy Before Cardiac Computed Tomography

Clinical trial2025-12-17Results expected Q3 2028 · ClinicalTrials.gov

Beta-blockeRs tO patieNts With CHronIc Obstructive puLmonary diseasE

Clinical trial2025-12-01Primary completion · ClinicalTrials.gov

Randomised, Double-blind, Placebo-controlled Clinical Trial to Evaluate the to Assess the Efficacy of Intravenous Metoprolol in Patients With Acute Respiratory Distress Syndrome (ARDS).

Clinical trial2025-10-06Terminated · ClinicalTrials.gov

IL-6 translation is a therapeutic target of human cytokine release syndrome.

Research2023-08-16The Journal of experimental medicine

Differential effects of nebivolol and metoprolol on insulin sensitivity and plasminogen activator inhibitor in the metabolic syndrome.

Research2012-02-21Hypertension (Dallas, Tex. : 1979)

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Metoprolol
Aliases & brands
BetalocDutoprolKapspargoLopresorLopressorLopressor HCTToprol(RS)-MetoprololDL-metoprololHydrochlorothiazide-MetoprololMetoprolol Tartrate
RxNorm CUI
6918
ChEMBL ID
CHEMBL13
ATC codes
C07AB02
UNII
GEB06NHM23

Clinical trials

121 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
121
registered trials across all phases
LATEST COMPLETION 2026
8
Active studies
7
Recruiting
83
Late-stage (III+)
76
Completed
37
Discontinued
PHASE DISTRIBUTIONn = 121
Early Phase 11Phase 125Phase 1 / 23Phase 29Phase 2 / 37Phase 39Phase 449Phase N / A18

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Beta-1 Adrenergic Inhibition to Reduce Cardiac Injury and Inflammation After Subarachnoid Hemorrhage (BADCATS)

RecruitingPH IVMadeleine Puissantn=202029

Dose-Response Interaction of Metoprolol and Sufentanil for Attenuating Hemodynamic Responses in Tracheal Intubation: Prospective Randomized Double-blind Study

Not yet recruitingPH IVFujian Provincial Hospitaln=9002027

Beta-blockeRs tO patieNts With CHronIc Obstructive puLmonary diseasE

Active, not recruitingPH IVKey trialOle Frobert, MD, PhDn=1,7132026

Use of Determination of Drug Levels to Optimize Pharmacotherapy of Heart Failure

Unknown statusPH IVUniversity Hospital Ostravan=1002026

Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA: a Randomised, Placebo-controlled, Mechanistic Study

RecruitingPH IVVZW Cardiovascular Research Center Aalstn=462025

Recent completions

Trials that read out recently, adding to the completed evidence base.

An Open-label, Drug-drug Interaction Study to Investigate the Effects of Amlitelimab on the Pharmacokinetics of Selected Cytochrome P450 Substrates in Adult Participants With Moderate-to-severe Atopic Dermatitis

CompletedPH ISanofin=232026

A Phase 1, Open-label, Single-arm Study to Investigate the Effect of Retatrutide on Metoprolol Pharmacokinetics in Healthy Participants

CompletedPH IEli Lilly and Companyn=302025

COMParison of the EffecT of mEdication Therapy: Anticoagulation Versus Anti-platelet Versus Migraine Therapy in Alleviating Migraine With Patent Foramen Ovale

CompletedPH IIChinese Academy of Medical Sciences, Fuwai Hospitaln=1,0002025

A Phase 1, Open-label, Drug-Drug Interaction Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple CYP450 Substrates in Patients With Moderate to Severe Atopic Dermatitis

CompletedPH IAmgenn=212025

Oral Melatonin Versus Intravenous Metoprolol or Dexmedetomidine for Attenuation of Stress Response to Endotracheal Intubation and Optimizing Surgical Field in Functional Endoscopic Sinus Surgery

CompletedN/AZagazig Universityn=282025

EFFECT of INTRAVENOUS METOPROLOL TARTRATE on MORTALITY in PATIENTS with SEPTIC SHOCK DUE to VENTILATOR-ASSOCIATED PNEUMONIA Thesis

CompletedPH IIAlexandria Universityn=1002024

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20122023
Major research themes1
Receptors, Chimeric Antigen1
Journals, researchers & institutions
Top journals
  • Hypertension (Dallas, Tex. : 1979)1
  • The Journal of experimental medicine1
Leading researchers
  • Ayers K1
  • Brown NJ1
  • Byrne LM1
  • Chen M1
  • DeMatteo A1
  • Han W1
  • Hu X1
  • Lin X1
Leading institutions
free-text, unnormalised
  • Beijing Key Laboratory for Immunological Research on Chronic Diseases1
  • Center for Synthetic and Systems Biology1
  • Division of Clinical Pharmacology1
  • Institute for Immunology and School of Medicine1
  • Ministry of Education Key Laboratory of Bioinformatics1
  • The First Medical Center1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials