Drug

Mirtazapine

In clinical development

Emerging researchLate-stage development

Also known as 6-Azamianserin, Mepirzapine, Mirataz, Remeron+4 more

6-Azamianserin, Mepirzapine, Mirataz, Remeron, Mirtazapin, Mirtazapina, 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine, Mirtazapinum.

RxNorm15996 ChEMBLCHEMBL654UNIIA051Q2099Q

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Phase II Randomized, Double-blind, Placebo-controlled Clinical Trial (RCT) to Evaluate the Ability of Mirtazapine (MZP) to Increase Methamphetamine (MA) Abstinence Among Treatment-seeking Medication for Opioid Use Disorder (MOUD) Adults

Clinical trial2026-07-02Results expected Q4 2026 · ClinicalTrials.gov

Repurposing Mirtazapine in Rett Syndrome: a Multicentric Open Label Phase II Study

Clinical trial2026-06-30Primary completion · ClinicalTrials.gov

Preliminary Study to Explore the Effects of Mirtazapine on Appetite in Advanced Cancer Patients

Clinical trial2026-06-12Results expected Q4 2027 · ClinicalTrials.gov

Mirtazapine and Quetiapine as Treatment for Postoperative Sleep Disturbance After Fast-track Knee Replacement

Clinical trial2026-05-01Primary completion · ClinicalTrials.gov

A Multi-centre, Double-blind Randomised Controlled Trial to Compare Mirtazapine Versus Placebo Over 12 Weeks in Patients With Multimorbid Major Depression and Inflammatory Bowel Disease (MD-IBD): a Feasibility Study

Clinical trial2026-04-01Primary completion · ClinicalTrials.gov

Evaluating the Effect of Mirtazapine on Anxiety in Parkinson's Disease Patients; a Randomized Double-blinded Placebo-controlled Clinical Trial

Clinical trial2025-12-20Primary completion · ClinicalTrials.gov

The Effect of Peri-operative Mirtazapine on Acute and Chronic Post Mastectomy Pain (Prospective Randomized Controlled Study)

Clinical trial2025-12-20Completed · ClinicalTrials.gov

Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator

Clinical trial2025-12-18Results expected Q4 2026 · ClinicalTrials.gov

Pilot Study of Mirtazapine for the Dual Treatment of Depression and Temozolomide-Induced Nausea and Vomiting (CINV) in Newly-Diagnosed High-Grade Glioma Patients on Temozolomide Therapy

Clinical trial2025-09-24Results expected Q4 2030 · ClinicalTrials.gov

Elucidating Mechanisms That Underlie Symptomatology of Functional Dyspepsia Using Novel Imaging Technique of SPECT/CT, MRI, High-Resolution Manometry and Biomarkers; and the Therapeutic Validation of Elucidated Mechanisms Using Neuromodulator Compounds

Clinical trial2024-12-31Primary completion · ClinicalTrials.gov

An Efficacy Study Comparing Olanzapine and Mirtazapine in the Improvement of Unintentional Weight Loss for Patients with Advanced Stage Cancer

Clinical trial2024-09-19Results expected Q4 2026 · ClinicalTrials.gov

Mirtazapine to reduce methamphetamine use: a randomized controlled trial.

Research2011-11-01Archives of general psychiatry

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Mirtazapine

Aliases & brands

6-AzamianserinMepirzapineMiratazRemeronMirtazapinMirtazapina1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepineMirtazapinum

RxNorm CUI

15996

ChEMBL ID

CHEMBL654

UNII

A051Q2099Q

Clinical trials

77 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2025

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 77

Early Phase 14Phase 17Phase 1 / 22Phase 225Phase 2 / 32Phase 39Phase 420Phase N / A8

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Efficacy of Mirtazapine in Major Depressive Disorder With Insomnia: A 6-Week Pre and Post Intervention Study

CompletedPH IVNational Institute of Mental Health, Dhakan=1352024

Mirtazapine vs Sumatriptan in the Treatment of Postdural Puncture Headache Following Obstetric Surgery Under Spinal Anesthesia: A Randomized Controlled Trial

CompletedPH IVAin Shams Universityn=2102023

Emergence Agitation After Nasal Surgery: a Randomized Controlled Comparison Between Melatonin and Mirtazapine

CompletedPH IVAin Shams Universityn=1652022

Assessing Quality of Life and the Feasibility of a Nutrition and Pharmacological Algorithm for Oncology Patients With Anorexia

TerminatedPH IVMontefiore Medical Centern=12021

Prophylactic Mirtazapine or Clonidine for Post-spinal Anesthesia Shivering in Patients Undergoing Urological Surgeries: a Randomized Controlled Trial

CompletedPH IVAin Shams Universityn=3002018

Recent completions

Trials that read out recently, adding to the completed evidence base.

The Effect of Peri-operative Mirtazapine on Acute and Chronic Post Mastectomy Pain (Prospective Randomized Controlled Study)

CompletedPH IAssiut Universityn=622025

Phase 1 Safety-interaction Study of Mirtazapine for the Treatment of Methamphetamine Use Disorder

CompletedPH ISan Francisco Department of Public Healthn=152024

Efficacy of Mirtazapine in Major Depressive Disorder With Insomnia: A 6-Week Pre and Post Intervention Study

CompletedPH IVNational Institute of Mental Health, Dhakan=1352024

Mirtazapine vs Sumatriptan in the Treatment of Postdural Puncture Headache Following Obstetric Surgery Under Spinal Anesthesia: A Randomized Controlled Trial

CompletedPH IVAin Shams Universityn=2102023

Mirtazapine Versus Dexamethasone in Preventing Postoperative Nausea and Vomiting After Lap Cholecystectomy a Comparative Study

CompletedPH IAin Shams Universityn=902023

Effect of Mirtazapine Versus Placebo on Appetite, Nutritional Status and Quality of Life in Non-small Cell Lung cáncer Patients With Anorexia; Randomized Double-blind Clinical Trial.

CompletedN/AInstituto Nacional de Cancerologia de Mexicon=862022

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Mirtazapine to reduce methamphetamine use: a randomized controlled trial.

Archives of general psychiatry · 2011 · 115 cites