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Drug

Misoprostol

Approved medicine
ClassProstanoid EP3 receptor agonistResearchOngoing clinical research

Also known as Arthrotec, Cytotec, Misoprostolum.

RxNorm42331ChEMBLCHEMBL606ATCG02AD06ATCA02BB01UNII0E43V0BB57
11
Active clinical trials
PTGER3
Primary target
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Misoprostol to Optimizing Prevention of Cancer of the Cervix: A Double-Blind Randomized Controlled Trial

Clinical trial2026-08-31Results expected Q4 2027 · ClinicalTrials.gov

Letrozole and Misoprostol for Early Pregnancy Loss Management: A Prospective Pilot Cohort Study

Clinical trial2026-08-10Status changed to Completed · ClinicalTrials.gov

Comparison of Efficacy and Safety of Oral Versus Vaginal Misoprostol in Missed Abortion in First Trimester of Pregnancy

Clinical trial2026-07-31Primary completion · ClinicalTrials.gov

Induction of Labor in Morbidly Obese Patients: Comparison of 50 mcg and 25 mcg Misoprostol - A Randomized Control Trial

Clinical trial2026-07-29Results expected Q4 2026 · ClinicalTrials.gov

Mifepristone Versus Misoprostol for Cervical Preparation Prior to Procedural Abortion at 12 to 16 Weeks' Gestation in an Academic Medical Center: a Randomized Controlled Pilot Trial

Clinical trial2026-07-24Results expected Q2 2027 · ClinicalTrials.gov

Cervical Ripening Balloon Compared With Vaginal Misoprostol for Cervical Ripening in Obese Woman at Term

Clinical trial2026-07-06Results expected Q4 2026 · ClinicalTrials.gov

Misoprostol Versus Pitocin for Induction of Labor in Patients With BMI > 30: A Randomized Controlled Trial

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

Foley Balloon for Cervical Preparation Before Dilation and Evacuation

Clinical trial2026-04-30Results expected Q1 2027 · ClinicalTrials.gov

Comparison of Vaginal PGE2 (Dinoprostone) and Vaginal Misoprostol for Induction of Labour in Primigravid Term Pregnancy

Clinical trial2026-04-29Primary completion · ClinicalTrials.gov

Comparison Between Preoperative Vaginal and Postoperative Sublingual Misoprostol for Prevention of Postpartum Hemorrhage During Cesarean Section

Clinical trial2026-01-01Primary completion · ClinicalTrials.gov

Oral Versus Vaginal Misoprostol Solution Among Pregnant Women Undergoing Induction of Labor At Ain Shams University Maternity Hospital a Randomized Controlled Trial

Clinical trial2025-08-31Primary completion · ClinicalTrials.gov

Rectal Misoprostol as a Hemostatic Agent During Abdominal Myomectomy

Clinical trial2025-07-29Results posted · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Misoprostol
Aliases & brands
ArthrotecCytotecMisoprostolum
RxNorm CUI
42331
ChEMBL ID
CHEMBL606
ATC codes
G02AD06A02BB01
UNII
0E43V0BB57
Primary mechanism
Prostanoid EP3 receptor agonist

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Prostaglandin E2 receptor EP3 subtype
PTGER3 · P43115
AGONISTProstanoid EP3 receptor agonist

Clinical trials

190 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
190
registered trials across all phases
LATEST COMPLETION 2025
11
Active studies
8
Recruiting
160
Late-stage (III+)
113
Completed
66
Discontinued
PHASE DISTRIBUTIONn = 190
Early Phase 16Phase 15Phase 219Phase 2 / 313Phase 330Phase 446Phase N / A71

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Prevention of Recurrent Ulcer Bleeding in Patients With Idiopathic Gastroduodenal Ulcer: a Double-blind Randomised Trial on Misoprostol Combined With Lansoprazole Versus Lansoprazole Alone (NRT_MISO Study)

RecruitingPH IVChinese University of Hong Kongn=1542027

Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of Premature Rupture of Membranes (PROM) at Term in Nulliparous: a Randomized Controlled Trial (RUBAPRO2).

Unknown statusPH IVUniversity Hospital, Clermont-Ferrandn=5202026

Sequential Use of Foley's Catheter and Low Dose Oral Misoprostol Versus Misoprostol Alone for Induction of Labour : a Multicentre Randomised Controlled Trial

CompletedPH IVKazakhstan's Medical University "KSPH"n=4002024

Induction of Labour at Term With Low Dose Oral Misoprostol Versus a Foley Catheter: a Multicentre Randomised Controlled Trial

CompletedPH IVKazakhstan's Medical University "KSPH"n=3002024

Rectal Misoprostol as a Hemostatic Agent During Abdominal Myomectomy

CompletedPH IVThe University of Texas Health Science Center at San Antonion=182024

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Pilot Study of Atorvastatin as a Potential Adjunct to Misoprostol for Termination of Pregnancy

CompletedPH IUniversity of Utahn=92025

Sequential Use of Foley's Catheter and Low Dose Oral Misoprostol Versus Misoprostol Alone for Induction of Labour : a Multicentre Randomised Controlled Trial

CompletedPH IVKazakhstan's Medical University "KSPH"n=4002024

Induction of Labour at Term With Low Dose Oral Misoprostol Versus a Foley Catheter: a Multicentre Randomised Controlled Trial

CompletedPH IVKazakhstan's Medical University "KSPH"n=3002024

Rectal Misoprostol as a Hemostatic Agent During Abdominal Myomectomy

CompletedPH IVThe University of Texas Health Science Center at San Antonion=182024

Mifepristone as an Adjunct to Transcervical Balloon for Labor Induction (MiLI): A Randomized Clinical Trial

CompletedPH IIIStanford Universityn=302023

Misoprostol Prior to Intrauterine Device Insertion in Non-menstruating Women

CompletedN/AAssiut Universityn=602023
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • ClinicalTrials.gov — clinical trials