Drug

Morphine

In clinical development

Emerging researchLate-stage developmentRising momentum

Also known as AVINza, DepoDur, Duramorph, Embeda+20 more

AVINza, DepoDur, Duramorph, Embeda, Infumorph, Kadian, M-Eslon, MS Contin, MSIR, Mitigo, Morfina, RMS, Rescudose, Roxanol, morfin, (-)-morphine, Morphia, Morphin, (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol, (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol, (5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol, Morphine Sulfate, Morphinum, Morphium.

RxNorm7052 ChEMBLCHEMBL70 ATCN02AA51 ATCA07DA52 ATCN02AA01UNII76I7G6D29C

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Multimodal Management for Perioperative Analgesia in Otolaryngology - Head and Neck Free Flap Reconstructive Surgery: A Prospective Study

Clinical trial2026-07-07Results posted · ClinicalTrials.gov

Phase III, Randomized, Double-blind Study to Assess the Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Analgesic Morphine Rachi Anesthesia for Major Digestive or Abdominal Surgery by Laparotomy.

Clinical trial2026-07-01Results expected Q3 2027 · ClinicalTrials.gov

The Effect of Targeted Stellate Ganglion Morphine Infiltration on Reperfusion Injury in STEMI Patients After Primary PCI: A Randomized Controlled Trial

Clinical trial2026-06-04Primary completion · ClinicalTrials.gov

Regional Anesthesia in Hip Arthroplasty- Comparison Between Two Techniques for Erector Spinae Plane Block

Clinical trial2026-05-12Results expected Q3 2026 · ClinicalTrials.gov

Efficacy of Anrikefon-based Patient-controlled Intravenous Analgesia for Pain Management After Laparoscopic Surgery: a Randomized, Double-blind, Active-controlled Pilot Tria

Clinical trial2026-04-24Results expected Q1 2027 · ClinicalTrials.gov

Ultrasound-Guided Transversalis Fascia Plane Block Versus Intrathecal Morphine for Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy: A Randomized Clinical Trial

Clinical trial2026-04-11Completed · ClinicalTrials.gov

Pain Reduction for Limb Injuries in Pediatric Emergency Departments: A Randomised Clinical Trial Comparing Intranasal Fentanyl or Intranasal Ketamine to Oral Morphine

Clinical trial2026-03-27Results expected Q1 2028 · ClinicalTrials.gov

To Evaluate the Efficacy and Safety of HSK55718 for Injection in Patients With Abdominal Postoperative Pain: a Multicenter, Randomized, Double-blind, Placebo/Positive Control Phase II Clinical Trial.

Clinical trial2026-03-24Results expected Q4 2026 · ClinicalTrials.gov

The Histone Lysine Demethylase KDM7A Contributes to Reward Memory via Fscn1-Induced Synaptic Plasticity in the Medial Prefrontal Cortex.

Research2025-01-21Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice.

Research2023-09-15The Journal of clinical investigation

mGluR5 from Primary Sensory Neurons Promotes Opioid-Induced Hyperalgesia and Tolerance by Interacting with and Potentiating Synaptic NMDA Receptors.

Research2023-07-14The Journal of neuroscience : the official journal of the Society for Neuroscience

APOLLO-2: A Randomized, Placebo and Active-Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein-Biased Ligand at the μ-Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty.

Research2019-06-24Pain practice : the official journal of World Institute of Pain

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Morphine

Aliases & brands

AVINzaDepoDurDuramorphEmbedaInfumorphKadianM-EslonMS ContinMSIRMitigoMorfinaRMSRescudoseRoxanolmorfin(-)-morphineMorphiaMorphin(5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol(5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol(5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diolMorphine SulfateMorphinumMorphium

RxNorm CUI

7052

ChEMBL ID

CHEMBL70

ATC codes

N02AA51A07DA52N02AA01

UNII

76I7G6D29C

Clinical trials

192 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

192

registered trials across all phases

LATEST COMPLETION 2026

Active studies

Recruiting

158

Late-stage (III+)

122

Completed

Discontinued

PHASE DISTRIBUTIONn = 192

Early Phase 12Phase 18Phase 1 / 25Phase 219Phase 2 / 36Phase 333Phase 474Phase N / A45

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine

WithdrawnPH IVUniversity of North Carolina, Chapel Hill2029

Efficacy of Anrikefon-based Patient-controlled Intravenous Analgesia for Pain Management After Laparoscopic Surgery: a Randomized, Double-blind, Active-controlled Pilot Tria

RecruitingPH IVPeking University First Hospitaln=1402027

Compare the Efficacy and Outcome Between Fentanyl and Morphine as Analgo-sedation in Mechanically Ventilated Patients

RecruitingPH IVUniversiti Sains Malaysian=1162025

Analgesic Efficacy of Intrathecal Fentanyl-Morphine Combination Versus Morphine Alone for Intraoperative Pain During Elective Cesarean Delivery: a Randomized Clinical Trial

Not yet recruitingPH IVSeoul National University Hospitaln=1862025

Perioperative Analgesic Management Using Conventional Versus Regional Nerve Block in Craniotomy Surgeries in Lower Middle-Income Class Countries

CompletedPH IVAga Khan Universityn=622025

Recent completions

Trials that read out recently, adding to the completed evidence base.

Ultrasound-Guided Transversalis Fascia Plane Block Versus Intrathecal Morphine for Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy: A Randomized Clinical Trial

CompletedN/ATanta Universityn=602026

Ultrasound-Guided Thoracic Paravertebral Block Versus External Oblique Intercostal Block for Postoperative Analgesia After Open Radical Nephrectomy: A Randomised Controlled Trial

CompletedN/AHacettepe Universityn=982026

A Randomized Controlled Non-Inferiority Trial Comparing Thoracic Paravertebral Block and Intrathecal Morphine for Postoperative Analgesia in Patients Undergoing Video-Assisted Thoracoscopic Surgery

CompletedN/AOndokuz Mayıs Universityn=702026

Intrathecal Non-preservative-free Morphine With Bupivacaine Versus Intrathecal Bupivacaine Alone for Analgesia in Unilateral Inguinal Hernia Repair Surgeries: A Randomized Controlled Clinical Trial.

CompletedPH IIICairo Universityn=502025

Perioperative Analgesic Management Using Conventional Versus Regional Nerve Block in Craniotomy Surgeries in Lower Middle-Income Class Countries

CompletedPH IVAga Khan Universityn=622025

Effect of Oliceridine Analgesia on Postoperative Nause and Vomiting in Laparoscopic Colorectal Surgery: A Randomized Trial

CompletedPH IVPeking University First Hospitaln=2522025

Research activity

6 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20122025

Most influential

Pain practice : the official journal of World Institute of Pain · 2019 · 130 cites

Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice.

The Journal of clinical investigation · 2023 · 37 cites

mGluR5 from Primary Sensory Neurons Promotes Opioid-Induced Hyperalgesia and Tolerance by Interacting with and Potentiating Synaptic NMDA Receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023 · 19 cites

Postoperative analgesic and behavioral effects of intranasal fentanyl, intravenous morphine, and intramuscular morphine in pediatric patients undergoing bilateral myringotomy and placement of ventilating tubes.

Anesthesia and analgesia · 2012 · 18 cites

Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage.

Pediatric emergency care · 2018 · 13 cites

The Histone Lysine Demethylase KDM7A Contributes to Reward Memory via Fscn1-Induced Synaptic Plasticity in the Medial Prefrontal Cortex.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025 · 5 cites

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Naloxone

Studied across the same disease area as Morphine in the shared literature.

1 shared disease1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials