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Drug

Olive Oil

In clinical development
Emerging researchLate-stage development
Also known as Clinolipid, OLEA EUROPAEA (OLIVE) FRUIT OIL, Sweet Oil, olive oil MISCELL OIL (ML)+1 more

Clinolipid, OLEA EUROPAEA (OLIVE) FRUIT OIL, Sweet Oil, olive oil MISCELL OIL (ML), olive oil@@MISCELL@OIL (ML).

RxNorm1309250ChEMBLCHEMBL2107910UNII6UYK2W1W1E
2
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Investigating N-3 Fatty Acids to Prevent Neonatal Tobacco-related outcomeS

Clinical trial2026-06-04Results posted · ClinicalTrials.gov

A Randomized, Double-Blind, Parallel-Controlled, Multicenter Clinical Trial of Antarctic Krill Oil in the Management of Knee Osteoarthritis Pain

Clinical trial2026-02-28Primary completion · ClinicalTrials.gov

Non-Surgical Treatment of Periodontitis in Menopausal Patients

Clinical trial2023-01-30Completed · ClinicalTrials.gov

Efficacy of Fish Oil or Olive Oil Supplementation on the Health Effects of Ozone Exposure in Healthy Young Subjects

Clinical trial2020-12-18Completed · ClinicalTrials.gov

Healthy Effects of Plant Polyphenols: Molecular Mechanisms.

Research2020-02-13International journal of molecular sciences

A 12-Week, Randomized, Double-Blind, Olive Oil-Controlled Phase 3 Study to Assess the Efficacy and Safety of EPANOVA™ in Subjects With Severe Hypertriglyceridemia (EVOLVE II)

Clinical trial2019-09-10Results posted · ClinicalTrials.gov

Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018.

Research2019-09-01Nutrients

Evaluation of the Efficacy and Safety of Indigo Naturalis Oil Extract on Psoriatic Nails

Clinical trial2019-08-07Results posted · ClinicalTrials.gov

Effects of Olive Oil and Bran Oil on Antioxidant Levels, Glycemic Control, and Lipid Profile in Patient Diabetes Mellitus Type 2

Clinical trial2018-10-05Completed · ClinicalTrials.gov

Effect of Omega-3 Fatty Acid on Vitamin D Activation in Hemodialysis Patients

Clinical trial2015-03-10Results posted · ClinicalTrials.gov

A 6-Week, Randomized, Double-Blind, Placebo(Olive Oil)-Controlled Study to Assess the Efficacy and Safety of Add-On Epanova® to Statin Therapy in Subjects With Persistent Hypertriglyceridemia and High Risk for Cardiovascular Disease

Clinical trial2014-12-05Results posted · ClinicalTrials.gov

Randomised Controlled Study on the Effect of a Kneipp Hot Cataplasm With Caraway Oil in the Treatment of Irritable Bowel Syndrome

Clinical trial2013-09-01Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Olive Oil
Aliases & brands
ClinolipidOLEA EUROPAEA (OLIVE) FRUIT OILSweet Oilolive oil MISCELL OIL (ML)olive oil@@MISCELL@OIL (ML)
RxNorm CUI
1309250
ChEMBL ID
CHEMBL2107910
UNII
6UYK2W1W1E

Clinical trials

16 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
16
registered trials across all phases
LATEST COMPLETION 2024
1
Active studies
1
Recruiting
10
Late-stage (III+)
14
Completed
1
Discontinued
PHASE DISTRIBUTIONn = 16
Phase 12Phase 24Phase 2 / 32Phase 33Phase 43Phase N / A2

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Non-Surgical Treatment of Periodontitis in Menopausal Patients

CompletedPH IVHadir F. El-Dessoukyn=202023

Effect of Omega-3 Fatty Acid on Vitamin D Activation in Hemodialysis Patients

CompletedPH IVDong-A Universityn=172012

Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops: Prospective Double-Blind Randomized Study

CompletedPH IVUniversity of Sao Paulo General Hospitaln=242011

A 12-Week, Randomized, Double-Blind, Olive Oil-Controlled Phase 3 Study to Assess the Efficacy and Safety of EPANOVA™ in Subjects With Severe Hypertriglyceridemia (EVOLVE II)

CompletedPH IIIAstraZenecan=3792014

A 6-Week, Randomized, Double-Blind, Placebo(Olive Oil)-Controlled Study to Assess the Efficacy and Safety of Add-On Epanova® to Statin Therapy in Subjects With Persistent Hypertriglyceridemia and High Risk for Cardiovascular Disease

CompletedPH IIIAstraZenecan=6462012

Recent completions

Trials that read out recently, adding to the completed evidence base.

Investigating N-3 Fatty Acids to Prevent Neonatal Tobacco-related outcomeS

CompletedPH IIVanderbilt University Medical Centern=2372024

Non-Surgical Treatment of Periodontitis in Menopausal Patients

CompletedPH IVHadir F. El-Dessoukyn=202023

Efficacy of Fish Oil or Olive Oil Supplementation on the Health Effects of Ozone Exposure in Healthy Young Subjects

CompletedPH IUniversity of North Carolina, Chapel Hilln=442020

Effects of Olive Oil and Bran Oil on Antioxidant Levels, Glycemic Control, and Lipid Profile in Patient Diabetes Mellitus Type 2

CompletedPH IIndonesia Universityn=102018

A 12-Week, Randomized, Double-Blind, Olive Oil-Controlled Phase 3 Study to Assess the Efficacy and Safety of EPANOVA™ in Subjects With Severe Hypertriglyceridemia (EVOLVE II)

CompletedPH IIIAstraZenecan=3792014

Randomised Controlled Study on the Effect of a Kneipp Hot Cataplasm With Caraway Oil in the Treatment of Irritable Bowel Syndrome

CompletedN/AUniversität Duisburg-Essenn=482013

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20192020
Major research themes4
Diet, Mediterranean2Dietary Fats1Nutrition Policy1Olive Oil1
Journals, researchers & institutions
Top journals
  • International journal of molecular sciences1
  • Nutrients1
Leading researchers
  • Alarcón-de-la-Lastra C1
  • Bucciantini M1
  • Calabrese EJ1
  • Calabrese V1
  • Castañer O1
  • Delgado-Rodríguez M1
  • Fitó M1
  • Gaforio JJ1
Leading institutions
free-text, unnormalised
  • Catalan Institute of Oncology1
  • Center for Advanced Studies in Olive Grove and Olive Oils1
  • Centre for Exercise1
  • Department of Experimental and Clinical Biomedical Sciences "Mario Serio"1
  • Girona Biomedical Research Institute (IDIBGI)1
  • Harvard TH Chan School of Public Health1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials