Back to discover
Drug

Omega-3 fatty acids

In clinical development
Emerging researchLate-stage developmentRising momentum
Also known as OMEGA-3 ACID, OMEGA-3 POLYUNSATURATED FATTY ACIDS, OMEGA-3 POLYUNSATURATES, Omega 3+10 more

OMEGA-3 ACID, OMEGA-3 POLYUNSATURATED FATTY ACIDS, OMEGA-3 POLYUNSATURATES, Omega 3, Omega-3, Omega-3 (n-3) polyunsaturated fatty acids, Omega-3 acid triglycerides, Omega-3 phospholipids, Omega-3-acid triglycerides, n-3 PUFAs, n-3 fatty acids, Omega 3 fatty acid, Omega 3 fatty acids, Omega-3 fatty acid.

RxNorm4301UNII71M78END5S
3
Research papers
13
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Anti-osteoarthritis Therapeutic Potential of Vitamin D With Omega-3 or Metformin: a Randomized Controlled Clinical Trial

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

Repositioning Omega-3 Fatty Acids For Treatment Of Glycaemia And Cardiometabolic Disease

Clinical trial2026-07-01Results expected Q4 2026 · ClinicalTrials.gov

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

Clinical trial2026-07-01Results expected Q1 2027 · ClinicalTrials.gov

Millions take omega-3 fish oil for brain health but a new study found no benefit

Research2026-06-29Research news · Science Daily

Millions take omega-3 fish oil for brain health but a new study found no benefit

Research2026-06-29Research news · Science Daily

Omega-3 fish oil shows promise against type 2 diabetes

Industry2026-05-31Science Daily

The Efficacy of Non-surgical Periodontal Therapy in Combination With Aspirin and Omega-3 Fatty Acids.

Clinical trial2026-04-15Results expected Q2 2027 · ClinicalTrials.gov

Diabetes Prevention in the Vitamin D and Omega-3 Trial

Clinical trial2026-04-03Results posted · ClinicalTrials.gov

Omega-3 fish oil supplements could backfire without this key enzyme

Industry2026-02-13Science Daily

Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans.

Research2015-04-07Diabetes care

Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance.

Research2013-01-17Diabetes

The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus.

Research2004-08-01The Journal of rheumatology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Omega-3 fatty acids
Aliases & brands
OMEGA-3 ACIDOMEGA-3 POLYUNSATURATED FATTY ACIDSOMEGA-3 POLYUNSATURATESOmega 3Omega-3Omega-3 (n-3) polyunsaturated fatty acidsOmega-3 acid triglyceridesOmega-3 phospholipidsOmega-3-acid triglyceridesn-3 PUFAsn-3 fatty acidsOmega 3 fatty acidOmega 3 fatty acidsOmega-3 fatty acid
RxNorm CUI
4301
UNII
71M78END5S

Clinical trials

129 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
129
registered trials across all phases
LATEST COMPLETION 2025
13
Active studies
4
Recruiting
94
Late-stage (III+)
81
Completed
35
Discontinued
PHASE DISTRIBUTIONn = 129
Early Phase 12Phase 13Phase 1 / 22Phase 228Phase 2 / 38Phase 327Phase 419Phase N / A40

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

A Prospective Study on the Effect of Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and Inflammatory Markers Between Two Ocular Hygiene Regimen Groups

Unknown statusPH IVUptown Eye Specialistsn=682024

Multi-factor Model Constraction for Early Warning and Diagnosis of Major Depressive Disorder

Unknown statusPH IVShanghai Mental Health Centern=6002023

Placebo-controlled Trial in Subjects at Ultra-high Risk for Psychosis With Omega-3 Fatty Acids in Europe

CompletedPH IVRene Kahnn=1452023

Cardiac Transfer of SARS-CoV-2 Spike Protein Circulation Techniques - Medicine Induced Hemodialysis on "Vaccinated" Immune Attacks

CompletedPH IVYang I. Pachankisn=12023

The Effect of Omega-3 Fatty Acids on Hypertriglyceridemia in Patients With Type 2 Diabetes Mellitus

CompletedPH IVShanghai Jiao Tong University School of Medicinen=3092021

Recent completions

Trials that read out recently, adding to the completed evidence base.

Impact of Omega-3 Supplementation on Omega-3 Status, Vitamin D and Mood in College Students

CompletedN/AUniversity of Colorado, Colorado Springsn=1032025

VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL

CompletedN/AKey trialBrigham and Women's Hospitaln=18,3532025

Impact of Omega 3 in Treatment of Inappropriate Sinus Tachycardia

CompletedN/ABenha Universityn=602024

A Pilot, Safety and Feasibility Trial of High-Dose Omega-3 Fatty Acids and High-Dose Cholecalciferol (Vitamin D) Supplementation in Type 1 Diabetes

CompletedPH I/IIRodolfo Alejandron=272024

Effects of Omega-3 as an Adjunct to Non-Surgical Periodontal Therapy on Chemerin Level

CompletedN/ABritish University In Egyptn=302024

Diabetes Prevention in the Vitamin D and Omega-3 Trial

CompletedPH IIIKey trialBrigham and Women's Hospitaln=22,2202024

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20042015
Major research themes2
Dietary Supplements2Insulin Resistance1
Journals, researchers & institutions
Top journals
  • Diabetes1
  • Diabetes care1
  • The Journal of rheumatology1
Leading researchers
  • Adu A1
  • Bell AL1
  • Campbell M1
  • Duffy EM1
  • Erfani R1
  • Finlin BS1
  • Hames KC1
  • Hannigan BM1
Leading institutions
free-text, unnormalised
  • and Barnstable Brown Diabetes and Obesity Center1
  • Mayo Clinic College of Medicine1
  • Northern Ireland Center for Food and Health (NICHE)1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials