Drug

Oxymorphone

In clinical development

Emerging researchEarly-to-mid development

Also known as (14S)-14-Hydroxydihydromorphinone, 14-Hydroxydihydromorphinone, Dihydrohydroxymorphinone, Dihydroxymorphinone+5 more

(14S)-14-Hydroxydihydromorphinone, 14-Hydroxydihydromorphinone, Dihydrohydroxymorphinone, Dihydroxymorphinone, Opana, Oximorfona, Oximorphonum, Oxymorphone Hydrochloride, Oxymorphonum.

RxNorm7814 ChEMBLCHEMBL963UNII9VXA968E0C

Research papers

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Levorphanol as a Second Line Opioid in Cancer Patients Undergoing Opioid Rotation: An Open Label Study

Clinical trial2023-06-15Terminated · ClinicalTrials.gov

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Clinical trial2019-03-07Results posted · ClinicalTrials.gov

A Pilot Study of Rapid Opioid Rotation and Titration of Oxymorphone

Clinical trial2016-02-03Results posted · ClinicalTrials.gov

Feasibility study of rapid opioid rotation and titration.

Research2011-01-01Pain physician

A Single Dose, Two-Period, Two-Treatment, Two-Sequence Crossover Bioequivalence Study of Oxymorphone Hydrochloride IR 10 mg Tablets, With a Naltrexone Block, Under Fasted Conditions

Clinical trial2008-06-01Completed · ClinicalTrials.gov

A Study to Evaluate the Relative Bioavailability of Oxymorphone 40 mg Extended-Release Tablets (Sandoz, Inc.) Compared to Opana ER (Oxymorphone Hydrochloride) Extended-Release Tablets, 40 mg (Endo Pharmaceuticals, Inc.) in Healthy Volunteers Under Fasted Conditions

Clinical trial2007-12-01Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Oxymorphone

Aliases & brands

(14S)-14-Hydroxydihydromorphinone14-HydroxydihydromorphinoneDihydrohydroxymorphinoneDihydroxymorphinoneOpanaOximorfonaOximorphonumOxymorphone HydrochlorideOxymorphonum

RxNorm CUI

7814

ChEMBL ID

CHEMBL963

UNII

9VXA968E0C

Clinical trials

5 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2017

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 5

Early Phase 11Phase 12Phase N / A2

Recent completions

Trials that read out recently, adding to the completed evidence base.

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

CompletedN/AKey trialVanderbilt Universityn=27,0342017

A Pilot Study of Rapid Opioid Rotation and Titration of Oxymorphone

CompletedN/AIcahn School of Medicine at Mount Sinain=122008

A Single Dose, Two-Period, Two-Treatment, Two-Sequence Crossover Bioequivalence Study of Oxymorphone Hydrochloride IR 10 mg Tablets, With a Naltrexone Block, Under Fasted Conditions

CompletedPH IRoxane Laboratoriesn=422008

CompletedPH ISandozn=502007

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Feasibility study of rapid opioid rotation and titration.

Pain physician · 2011 · 9 cites