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Drug

Ozone

In clinical development
Emerging researchLate-stage development

Also known as ozono.

RxNorm2289011ChEMBLCHEMBL2447938UNII66H7ZZK23N
2
Research papers
3
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Wavelet-derived periodic variability and regional differences of surface ozone in southeastern Nigeria from 2002 to 2023

Industry2026-08-01Nature — Environmental Sciences

Wavelet-derived periodic variability and regional differences of surface ozone in southeastern Nigeria from 2002 to 2023

Industry2026-08-01Nature — Climate Sciences

The dominant role of temperature in seasonal ozone sensitivity changes in China

Industry2026-07-31Nature — Environmental Sciences

In vitro evaluation of bactericidal efficacy, cytotoxicity and genotoxicity of combined negative ions and ozone treatment

Industry2026-07-16Nature — Environmental Sciences

Ozone based advanced oxidation for antibiotic amoxicillin removal from aqueous environment with kinetic and economic evaluation

Industry2026-07-14Nature — Environmental Sciences

Aligning climate and air quality goals demands early VOC control for China’s ozone pollution

Industry2026-07-09Nature — Climate Sciences

CXCL10/CXCR3 Regulation of Ozone-Induced Epithelial Permeability

Clinical trial2026-06-15Results posted · ClinicalTrials.gov

Mechanisms of Ozone-Induced Alterations in Efferocytosis and Phagocytosis

Clinical trial2026-06-15Results posted · ClinicalTrials.gov

Macrophage Regulation of Ozone-Induced Lung Inflammation

Clinical trial2026-05-15Results expected Q2 2028 · ClinicalTrials.gov

Application of Gaseous Ozone in the Surgical Extraction of Impacted Mandibular Third Molars: Impact on the Incidence of Postoperative Complications and Healing Processes

Clinical trial2025-12-15Completed · ClinicalTrials.gov

Ozone efficacy for the control of airborne viruses: Bacteriophage and norovirus models.

Research2020-04-10PloS one

Ozone Pollution: A Major Health Hazard Worldwide.

Research2019-10-31Frontiers in immunology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Ozone
Aliases & brands
ozono
RxNorm CUI
2289011
ChEMBL ID
CHEMBL2447938
UNII
66H7ZZK23N

Clinical trials

23 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
23
registered trials across all phases
LATEST COMPLETION 2025
3
Active studies
3
Recruiting
17
Late-stage (III+)
12
Completed
8
Discontinued
PHASE DISTRIBUTIONn = 23
Early Phase 11Phase 13Phase 22Phase 2 / 33Phase 32Phase 42Phase N / A10

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Examining the Effect of Salbutamol Use in Asthma and/or Exercise Induced Bronchoconstriction Whilst Exercising in Ozone Air Pollution

CompletedPH IVUniversity of British Columbian=182023

Methylene Blue and Ozone in Early Sepsis , a Randomized Double Blind Trial

Unknown statusPH IVAssiut Universityn=402017

Effectiveness and Cost-effectiveness of Ozone Therapy in Patients With Pain Secondary to Chemotherapy-induced Peripheral Neuropathy. Randomized, Triple-blind Clinical Trial (O3NPIQ)

RecruitingPH II/IIIBernardino Clavo, MD, PhDn=422027

Application of Gaseous Ozone in the Surgical Extraction of Impacted Mandibular Third Molars: Impact on the Incidence of Postoperative Complications and Healing Processes

CompletedPH IIIJelena Krunicn=202025

Intra-articular Oxygen-ozone Therapy for the Treatment of Knee Osteoarthritis: a Randomized, Double-blind, Clinical Trial Compared With Hyaluronic Acid

Unknown statusPH IIIHumanitas Clinical and Research Centern=1202022

Recent completions

Trials that read out recently, adding to the completed evidence base.

Application of Gaseous Ozone in the Surgical Extraction of Impacted Mandibular Third Molars: Impact on the Incidence of Postoperative Complications and Healing Processes

CompletedPH IIIJelena Krunicn=202025

The Effect of Ozone Treatment on Coronary Flow Reserve in Patients With Heart Failure Having Reduced Ejection Fraction

CompletedN/AEkrem Bilal Karaayvazn=602024

CXCL10/CXCR3 Regulation of Ozone-Induced Epithelial Permeability

CompletedPH IRobert Tighe, MDn=142024

Effect of Intraarticular Ozone, Prolotherapy or Dexmedetomidine in Pain Limitation in Knee Osteoarthritis: A Randomized Prospective Study

CompletedN/ATanta Universityn=602023

Examining the Effect of Salbutamol Use in Asthma and/or Exercise Induced Bronchoconstriction Whilst Exercising in Ozone Air Pollution

CompletedPH IVUniversity of British Columbian=182023

Mechanisms of Ozone-Induced Alterations in Efferocytosis and Phagocytosis

CompletedPH IRobert Tighe, MDn=352023

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20192020
Major research themes3
Air Microbiology1Air Pollution1Global Health1
Journals, researchers & institutions
Top journals
  • Frontiers in immunology1
  • PloS one1
Leading researchers
  • Dubuis ME1
  • Duchaine C1
  • Dumont-Leblond N1
  • Fang Z1
  • Jean J1
  • Laliberté C1
  • Turgeon N1
  • Veillette M1
Leading institutions
free-text, unnormalised
  • Center for Global Health1
  • Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval1
  • Global Health Research Center1
  • Guangzhou Institute of Respiratory Health1
  • Nicholas School of the Environment and Duke Global Health Institute1
  • State Key Laboratory of Environmental Criteria and Risk Assessment & Environmental Standards Institute1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials