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Drug

Perflutren

Approved · EMA
Late-stage development
Also known as C3F3 - perfluoropropane, Freon 218, OCTAFLUOROPROPANE, Octafluorpropan+4 more

C3F3 - perfluoropropane, Freon 218, OCTAFLUOROPROPANE, Octafluorpropan, Oktafluorpropan, Perfluoropropane, Perflutreno, 1,1,1,2,2,3,3,3-octafluoropropane.

1
Active clinical trials
2
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Vasodilatory Effects of Light on Peripheral Artery Disease

Clinical trial2026-05-01Results expected Q4 2028 · ClinicalTrials.gov

Approval: Luminity (EMA)

Regulatory2006-09-20EMA

The Silicone Study

Clinical trial2005-06-24Completed · ClinicalTrials.gov

Approval: Optison (EMA)

Regulatory1998-05-17EMA

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Perflutren
Aliases & brands
C3F3 - perfluoropropaneFreon 218OCTAFLUOROPROPANEOctafluorpropanOktafluorpropanPerfluoropropanePerflutreno1,1,1,2,2,3,3,3-octafluoropropane
RxNorm CUI
283753
ChEMBL ID
CHEMBL1663
UNII
CK0N3WH0SR
Regulatory jurisdictions
ema

Regulatory timeline

2 events

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
1998-05-17
Latest approval
2006-09-20
Authorities
EMA
Total events
2
emaEuropean Medicines Agency· 2 events
2006-09-20Approval
Approval: Luminity (EMA)
Indication: This medicinal product is for diagnostic use only. Luminity is an ultrasound contrast-enhancing agent for use in patients in whom non-contrast echocardiography was suboptimalShow full indication

This medicinal product is for diagnostic use only. Luminity is an ultrasound contrast-enhancing agent for use in patients in whom non-contrast echocardiography was suboptimal (suboptimal is considered to indicate that at least two of six segments in the 4- or 2-chamber view of the ventricular border were not evaluable) and who have suspected or established coronary artery disease, to provide opacification of cardiac chambers and improvement of left ventricular endocardial border delineation at both rest and stress.

Evidence ↗
1998-05-17Approval
Approval: Optison (EMA)
Indication: This medicinal product is for diagnostic use only. Optison is a transpulmonary echocardiographic contrast agent for use in patients with suspected or established cardiovascularShow full indication

This medicinal product is for diagnostic use only. Optison is a transpulmonary echocardiographic contrast agent for use in patients with suspected or established cardiovascular disease to provide opacification of cardiac chambers, enhance left-ventricular-endocardial-border delineation with resulting improvement in wall-motion visualisation. Optison should only be used in patients where the study without contrast enhancement is inconclusive.

Evidence ↗

Contains information from the European Medicines Agency (European Medicines Agency), © EMA, reused under CC BY 4.0.

Clinical trials

4 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
4
registered trials across all phases
LATEST COMPLETION 2020
1
Active studies
1
Recruiting
4
Late-stage (III+)
2
Completed
1
Discontinued
PHASE DISTRIBUTIONn = 4
Phase 31Phase N / A3

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

The Silicone Study

CompletedPH IIINational Eye Institute (NEI)2005

Recent completions

Trials that read out recently, adding to the completed evidence base.

References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.