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Drug

Phenylephrine

In clinical development
Emerging researchLate-stage developmentRising momentum
Also known as AK-Dilate, AK-Nefrin, Afrin Nasal, Ah-Chew D+257 more

AK-Dilate, AK-Nefrin, Afrin Nasal, Ah-Chew D, Airacof, Ala-Hist AC, Alahist D, Aldex D, Aldex-CT, Atuss G, Atuss HD, Atuss MS, B-Tuss, Benadryl Allergy Plus Congestion, Benadryl-D Allergy and Sinus, Biorphen, Brompheniramine-Dextromethorph-Phenylephrine, Brompheniramine-Phenylephrine, Brovex PBC, C-Tanna 12D, Canges-HC, Carbatuss-CL, Carbetapentane-Phenylephrine, Chemdal HD, Chemdal HD Plus, Chemtussin HC, Chlopheniramine-Phenylephrine, Chlorgest HD, Chlorphen HD, Codimal DH, Codimal PH, Colrex, Comtussin HC, Crantex HC, Cyclomydril, Cyndal HD, Cytuss HC, Cytuss-HC NR, Dallergy, Dallergy Reformulated Nov 2011, De-Chlor G, De-Chlor HC, De-Chlor HD, De-Chlor MR, Demi-Cof, Despec-SF, Dexbrompheniramine-DM-Phenylephrine, Dicomal-DH, Dicomal-PH, Dimetapp Cold Drops, Ditussin-HC, Donatuss DC, Donatussin DC, Donatussin MAX, Dristan, DroTuss-CP, Duo-Medihaler, Duradal HD, Duradal HD Plus, Dynatuss HC, Dytan-CD, Dytan-CS, Dytan-D, Dytan-HC, Ear-gesic, Echotuss-HC, Ed-TLC, Ed-Tuss HC, Efasin-HD, Endagen-HD, Endal CD, Endal HD, Endal-HD Plus, Enditussin-HD, Endotuss-HD, Enplus-HD, Entex HC, Excof, Exetuss-HC, Exo-Tuss, Extendryl PEM, Fenilefrina, FluTuss HC, Formulation R, Gentex HC, Guiaphen HD, Guiaplex HC, H-C Tussive, H-C Tussive-NR, HYDROcodone CP, HYDROcodone HD, Hem-Prep, Hemorid, Hemorid Cream, Hemorid Ointment, Hemorrhoidal GRX, Hi-Tuss HC, Histinex HC, Histussin HC, Histussin-HC, Hyco-DH, Hycomal DH, Hycomine Compound, Hydro GP, Hydro-PC II, HydroFed, Hydron CP, Hydrophene DH, Hyphen-HD, Immphentiv, Iodal HD, Isopto Frin, K-Tan, KG-Dal HD, Levall 5.0, Liquicough HC, Little Noses Decongestant, Lortuss HC, Lusonal, M-End PE, M-Phen, Max HC, Maxi-Tuss HC, Maxi-Tuss SA, Maxiphen CD, Maxiphen CDX, Med-Hist-HC, Medicone Hemorrhoidal, Mintuss G, Mintuss HC, Mintuss MR, Mintuss MS, MonteFlu HC, Murocoll 2, Myci Spray, Mydcombi, Mydfrin, Nalex-DH, Nariz HC, Nasatuss, Nasop, Nasopen PE, Nasotuss, Nazarin HC, Neo-Synephrine, Notuss PD, Notuss-PE, Novahistine DH, Omidria, Otigesic, PCM, Pancof-PD, Pediacof, Pedituss, Phendal-HD, Phenergan VC, Phenergan VC with Codeine, Phenyl-T, Phenylephrine Nasal, Phenylephrine Ophthalmic, Phenylephrine, Topical, Phenylephrine-Tropicamide, Poly Hist DHC, Poly Hist Forte (old formulation), Poly Hist PD, Poly Hist PD (old formulation), Poly Tussin EX, Poly-Tussin AC, Poly-Tussin DHC, Prefrin, Prep-Hem, Prohist CD, Prohist LQ, Pyril D, Pyril Tann-12, Pyrlex PD, Q-Tuss with Hydrocodone, Qual-Tussin DC, Quindal HD, R(-)-Phenylephrine, RectiCare Advance Cream, Relacon-HC, Relasin-HC, Rhinall, Rindal HPD, Rindal-HD, Rolatuss, Rolatuss with Hydrocodone, Ru-Hist D, Ru-Hist-D, Ry-T-12, Ryna-12, S-T Forte, Simuc-HD, Statuss Green, Sudafed PE, Sudo-Tab, Sudogest PE, T- Koff, TL-Hist CD, Tannate 12D S, Tannihist-12D, Triant-HC, Trimal DH, Tusana-D, Tusdec-HC, Tuss-DS, Tuss-HC, Tuss-PD, Tussafed-HC, Tusscough DHC, Tussi-12D, Tussi-12D S, Tussinate, Tussirex, Tussive HC, Tussplex, Tympagesic, Uni Tuss HC, Uni-Lev 5.0, Uni-Tricof HC, Vanacof, Vanacof APE, Vanex-HD, Vasosulf, Vazculep, VazoTuss HC, Vazotab, Ventuss, Vetuss HC Syrup, Viravan-S, Viravan-T, Wal-Dryl PE, Wal-Dryl-D, Wal-Four, Wal-Phed PE, Xyralid, Z-Cof HC, Zincfrin, Zotex HC, Zotex-C, l-(3-Hydroxyphenyl)-N-methylethanolamine, Antipyrine/Benzocaine/Phenylephrine, Brompheniramine/Dihydrocodeine/PE, Carbetapentane/Diphenhydramine/Phenylephrine, Carbetapentane/Guaifenesin/Phenylephrine, Chlorpheniramine/Dextromethorphan/Phenylephrine, Chlorpheniramine/GuaiFENesin/Phenylephrine, Chlorpheniramine/Hydrocodone/Phenylephrine, Chlorpheniramine/Phenylephrin/Phenyltoloxamin, Chlorpheniramine/Phenylephrine/Pyrilamine, Dexbrompheniramine/Hydrocodone/Phenylephrine, Dexchlorpheniramine/Dextromethorphan/Phenylephrine, Dextromethorphan/Guaifenesin/Phenylephrine, Dextromethorphan/Phenylephrine/Pyrilamine, Guaifenesin/Hydrocodone/Phenylephrine, Guaifenesin/PE/PPA, Phenylephrine HCl, Phenylephrine Hydrochloride, Phenylephrinum, R-Tannic-S A/D.

3
Research papers
16
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity

Clinical trial2026-06-30Primary completion · ClinicalTrials.gov

Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury - A Randomized Control Trial

Clinical trial2026-05-14Results expected Q2 2028 · ClinicalTrials.gov

Clinical Study of DA-001 as a Treatment for Hair Shedding Reduction and Hair Re-Growth

Clinical trial2026-04-13Results expected Q1 2027 · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Phenylephrine
Aliases & brands
AK-DilateAK-NefrinAfrin NasalAh-Chew DAiracofAla-Hist ACAlahist DAldex DAldex-CTAtuss GAtuss HDAtuss MSB-TussBenadryl Allergy Plus CongestionBenadryl-D Allergy and SinusBiorphenBrompheniramine-Dextromethorph-PhenylephrineBrompheniramine-PhenylephrineBrovex PBCC-Tanna 12DCanges-HCCarbatuss-CLCarbetapentane-PhenylephrineChemdal HDChemdal HD PlusChemtussin HCChlopheniramine-PhenylephrineChlorgest HDChlorphen HDCodimal DHCodimal PHColrexComtussin HCCrantex HCCyclomydrilCyndal HDCytuss HCCytuss-HC NRDallergyDallergy Reformulated Nov 2011De-Chlor GDe-Chlor HCDe-Chlor HDDe-Chlor MRDemi-CofDespec-SFDexbrompheniramine-DM-PhenylephrineDicomal-DHDicomal-PHDimetapp Cold DropsDitussin-HCDonatuss DCDonatussin DCDonatussin MAXDristanDroTuss-CPDuo-MedihalerDuradal HDDuradal HD PlusDynatuss HCDytan-CDDytan-CSDytan-DDytan-HCEar-gesicEchotuss-HCEd-TLCEd-Tuss HCEfasin-HDEndagen-HDEndal CDEndal HDEndal-HD PlusEnditussin-HDEndotuss-HDEnplus-HDEntex HCExcofExetuss-HCExo-TussExtendryl PEMFenilefrinaFluTuss HCFormulation RGentex HCGuiaphen HDGuiaplex HCH-C TussiveH-C Tussive-NRHYDROcodone CPHYDROcodone HDHem-PrepHemoridHemorid CreamHemorid OintmentHemorrhoidal GRXHi-Tuss HCHistinex HCHistussin HCHistussin-HCHyco-DHHycomal DHHycomine CompoundHydro GPHydro-PC IIHydroFedHydron CPHydrophene DHHyphen-HDImmphentivIodal HDIsopto FrinK-TanKG-Dal HDLevall 5.0Liquicough HCLittle Noses DecongestantLortuss HCLusonalM-End PEM-PhenMax HCMaxi-Tuss HCMaxi-Tuss SAMaxiphen CDMaxiphen CDXMed-Hist-HCMedicone HemorrhoidalMintuss GMintuss HCMintuss MRMintuss MSMonteFlu HCMurocoll 2Myci SprayMydcombiMydfrinNalex-DHNariz HCNasatussNasopNasopen PENasotussNazarin HCNeo-SynephrineNotuss PDNotuss-PENovahistine DHOmidriaOtigesicPCMPancof-PDPediacofPeditussPhendal-HDPhenergan VCPhenergan VC with CodeinePhenyl-TPhenylephrine NasalPhenylephrine OphthalmicPhenylephrine, TopicalPhenylephrine-TropicamidePoly Hist DHCPoly Hist Forte (old formulation)Poly Hist PDPoly Hist PD (old formulation)Poly Tussin EXPoly-Tussin ACPoly-Tussin DHCPrefrinPrep-HemProhist CDProhist LQPyril DPyril Tann-12Pyrlex PDQ-Tuss with HydrocodoneQual-Tussin DCQuindal HDR(-)-PhenylephrineRectiCare Advance CreamRelacon-HCRelasin-HCRhinallRindal HPDRindal-HDRolatussRolatuss with HydrocodoneRu-Hist DRu-Hist-DRy-T-12Ryna-12S-T ForteSimuc-HDStatuss GreenSudafed PESudo-TabSudogest PET- KoffTL-Hist CDTannate 12D STannihist-12DTriant-HCTrimal DHTusana-DTusdec-HCTuss-DSTuss-HCTuss-PDTussafed-HCTusscough DHCTussi-12DTussi-12D STussinateTussirexTussive HCTussplexTympagesicUni Tuss HCUni-Lev 5.0Uni-Tricof HCVanacofVanacof APEVanex-HDVasosulfVazculepVazoTuss HCVazotabVentussVetuss HC SyrupViravan-SViravan-TWal-Dryl PEWal-Dryl-DWal-FourWal-Phed PEXyralidZ-Cof HCZincfrinZotex HCZotex-Cl-(3-Hydroxyphenyl)-N-methylethanolamineAntipyrine/Benzocaine/PhenylephrineBrompheniramine/Dihydrocodeine/PECarbetapentane/Diphenhydramine/PhenylephrineCarbetapentane/Guaifenesin/PhenylephrineChlorpheniramine/Dextromethorphan/PhenylephrineChlorpheniramine/GuaiFENesin/PhenylephrineChlorpheniramine/Hydrocodone/PhenylephrineChlorpheniramine/Phenylephrin/PhenyltoloxaminChlorpheniramine/Phenylephrine/PyrilamineDexbrompheniramine/Hydrocodone/PhenylephrineDexchlorpheniramine/Dextromethorphan/PhenylephrineDextromethorphan/Guaifenesin/PhenylephrineDextromethorphan/Phenylephrine/PyrilamineGuaifenesin/Hydrocodone/PhenylephrineGuaifenesin/PE/PPAPhenylephrine HClPhenylephrine HydrochloridePhenylephrinumR-Tannic-S A/D
RxNorm CUI
8163
ChEMBL ID
CHEMBL1215
UNII
1WS297W6MV

Clinical trials

152 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
152
registered trials across all phases
LATEST COMPLETION 2026
16
Active studies
14
Recruiting
122
Late-stage (III+)
98
Completed
38
Discontinued
PHASE DISTRIBUTIONn = 152
Early Phase 18Phase 17Phase 1 / 22Phase 213Phase 2 / 37Phase 311Phase 448Phase N / A56

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20132017
Major research themes2
Black People1White People1
Journals, researchers & institutions
Top journals
  • The pharmacogenomics journal2
  • Hypertension (Dallas, Tex. : 1979)1
Leading researchers
  • Adefurin A3
  • Ghimire LV3
  • Kohli U3
  • Kurnik D3
  • Muszkat M3
  • Paranjape SY3
  • Sofowora GG3
  • Stein CM3
Leading institutions
free-text, unnormalised
  • Division of Clinical Pharmacology3
  • Center for Human Genetics Research2
  • Clinical Pharmacology Unit1
  • Technion-Israel Institute of Technology1
  • Vanderbilt Genetics Institute1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials