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Drug

Phenylephrine

Established medicine
ResearchActive indication expansion
Also known as AK-Dilate, AK-Nefrin, Afrin Nasal, Ah-Chew D+257 more

AK-Dilate, AK-Nefrin, Afrin Nasal, Ah-Chew D, Airacof, Ala-Hist AC, Alahist D, Aldex D, Aldex-CT, Atuss G, Atuss HD, Atuss MS, B-Tuss, Benadryl Allergy Plus Congestion, Benadryl-D Allergy and Sinus, Biorphen, Brompheniramine-Dextromethorph-Phenylephrine, Brompheniramine-Phenylephrine, Brovex PBC, C-Tanna 12D, Canges-HC, Carbatuss-CL, Carbetapentane-Phenylephrine, Chemdal HD, Chemdal HD Plus, Chemtussin HC, Chlopheniramine-Phenylephrine, Chlorgest HD, Chlorphen HD, Codimal DH, Codimal PH, Colrex, Comtussin HC, Crantex HC, Cyclomydril, Cyndal HD, Cytuss HC, Cytuss-HC NR, Dallergy, Dallergy Reformulated Nov 2011, De-Chlor G, De-Chlor HC, De-Chlor HD, De-Chlor MR, Demi-Cof, Despec-SF, Dexbrompheniramine-DM-Phenylephrine, Dicomal-DH, Dicomal-PH, Dimetapp Cold Drops, Ditussin-HC, Donatuss DC, Donatussin DC, Donatussin MAX, Dristan, DroTuss-CP, Duo-Medihaler, Duradal HD, Duradal HD Plus, Dynatuss HC, Dytan-CD, Dytan-CS, Dytan-D, Dytan-HC, Ear-gesic, Echotuss-HC, Ed-TLC, Ed-Tuss HC, Efasin-HD, Endagen-HD, Endal CD, Endal HD, Endal-HD Plus, Enditussin-HD, Endotuss-HD, Enplus-HD, Entex HC, Excof, Exetuss-HC, Exo-Tuss, Extendryl PEM, Fenilefrina, FluTuss HC, Formulation R, Gentex HC, Guiaphen HD, Guiaplex HC, H-C Tussive, H-C Tussive-NR, HYDROcodone CP, HYDROcodone HD, Hem-Prep, Hemorid, Hemorid Cream, Hemorid Ointment, Hemorrhoidal GRX, Hi-Tuss HC, Histinex HC, Histussin HC, Histussin-HC, Hyco-DH, Hycomal DH, Hycomine Compound, Hydro GP, Hydro-PC II, HydroFed, Hydron CP, Hydrophene DH, Hyphen-HD, Immphentiv, Iodal HD, Isopto Frin, K-Tan, KG-Dal HD, Levall 5.0, Liquicough HC, Little Noses Decongestant, Lortuss HC, Lusonal, M-End PE, M-Phen, Max HC, Maxi-Tuss HC, Maxi-Tuss SA, Maxiphen CD, Maxiphen CDX, Med-Hist-HC, Medicone Hemorrhoidal, Mintuss G, Mintuss HC, Mintuss MR, Mintuss MS, MonteFlu HC, Murocoll 2, Myci Spray, Mydcombi, Mydfrin, Nalex-DH, Nariz HC, Nasatuss, Nasop, Nasopen PE, Nasotuss, Nazarin HC, Neo-Synephrine, Notuss PD, Notuss-PE, Novahistine DH, Omidria, Otigesic, PCM, Pancof-PD, Pediacof, Pedituss, Phendal-HD, Phenergan VC, Phenergan VC with Codeine, Phenyl-T, Phenylephrine Nasal, Phenylephrine Ophthalmic, Phenylephrine, Topical, Phenylephrine-Tropicamide, Poly Hist DHC, Poly Hist Forte (old formulation), Poly Hist PD, Poly Hist PD (old formulation), Poly Tussin EX, Poly-Tussin AC, Poly-Tussin DHC, Prefrin, Prep-Hem, Prohist CD, Prohist LQ, Pyril D, Pyril Tann-12, Pyrlex PD, Q-Tuss with Hydrocodone, Qual-Tussin DC, Quindal HD, R(-)-Phenylephrine, RectiCare Advance Cream, Relacon-HC, Relasin-HC, Rhinall, Rindal HPD, Rindal-HD, Rolatuss, Rolatuss with Hydrocodone, Ru-Hist D, Ru-Hist-D, Ry-T-12, Ryna-12, S-T Forte, Simuc-HD, Statuss Green, Sudafed PE, Sudo-Tab, Sudogest PE, T- Koff, TL-Hist CD, Tannate 12D S, Tannihist-12D, Triant-HC, Trimal DH, Tusana-D, Tusdec-HC, Tuss-DS, Tuss-HC, Tuss-PD, Tussafed-HC, Tusscough DHC, Tussi-12D, Tussi-12D S, Tussinate, Tussirex, Tussive HC, Tussplex, Tympagesic, Uni Tuss HC, Uni-Lev 5.0, Uni-Tricof HC, Vanacof, Vanacof APE, Vanex-HD, Vasosulf, Vazculep, VazoTuss HC, Vazotab, Ventuss, Vetuss HC Syrup, Viravan-S, Viravan-T, Wal-Dryl PE, Wal-Dryl-D, Wal-Four, Wal-Phed PE, Xyralid, Z-Cof HC, Zincfrin, Zotex HC, Zotex-C, l-(3-Hydroxyphenyl)-N-methylethanolamine, Antipyrine/Benzocaine/Phenylephrine, Brompheniramine/Dihydrocodeine/PE, Carbetapentane/Diphenhydramine/Phenylephrine, Carbetapentane/Guaifenesin/Phenylephrine, Chlorpheniramine/Dextromethorphan/Phenylephrine, Chlorpheniramine/GuaiFENesin/Phenylephrine, Chlorpheniramine/Hydrocodone/Phenylephrine, Chlorpheniramine/Phenylephrin/Phenyltoloxamin, Chlorpheniramine/Phenylephrine/Pyrilamine, Dexbrompheniramine/Hydrocodone/Phenylephrine, Dexchlorpheniramine/Dextromethorphan/Phenylephrine, Dextromethorphan/Guaifenesin/Phenylephrine, Dextromethorphan/Phenylephrine/Pyrilamine, Guaifenesin/Hydrocodone/Phenylephrine, Guaifenesin/PE/PPA, Phenylephrine HCl, Phenylephrine Hydrochloride, Phenylephrinum, R-Tannic-S A/D.

3
Research papers
14
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury - A Randomized Control Trial

Clinical trial2026-05-14Results expected Q2 2028 · ClinicalTrials.gov

Clinical Study of DA-001 as a Treatment for Hair Shedding Reduction and Hair Re-Growth

Clinical trial2026-04-13Results expected Q1 2027 · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Phenylephrine
Aliases & brands
AK-DilateAK-NefrinAfrin NasalAh-Chew DAiracofAla-Hist ACAlahist DAldex DAldex-CTAtuss GAtuss HDAtuss MSB-TussBenadryl Allergy Plus CongestionBenadryl-D Allergy and SinusBiorphenBrompheniramine-Dextromethorph-PhenylephrineBrompheniramine-PhenylephrineBrovex PBCC-Tanna 12DCanges-HCCarbatuss-CLCarbetapentane-PhenylephrineChemdal HDChemdal HD PlusChemtussin HCChlopheniramine-PhenylephrineChlorgest HDChlorphen HDCodimal DHCodimal PHColrexComtussin HCCrantex HCCyclomydrilCyndal HDCytuss HCCytuss-HC NRDallergyDallergy Reformulated Nov 2011De-Chlor GDe-Chlor HCDe-Chlor HDDe-Chlor MRDemi-CofDespec-SFDexbrompheniramine-DM-PhenylephrineDicomal-DHDicomal-PHDimetapp Cold DropsDitussin-HCDonatuss DCDonatussin DCDonatussin MAXDristanDroTuss-CPDuo-MedihalerDuradal HDDuradal HD PlusDynatuss HCDytan-CDDytan-CSDytan-DDytan-HCEar-gesicEchotuss-HCEd-TLCEd-Tuss HCEfasin-HDEndagen-HDEndal CDEndal HDEndal-HD PlusEnditussin-HDEndotuss-HDEnplus-HDEntex HCExcofExetuss-HCExo-TussExtendryl PEMFenilefrinaFluTuss HCFormulation RGentex HCGuiaphen HDGuiaplex HCH-C TussiveH-C Tussive-NRHYDROcodone CPHYDROcodone HDHem-PrepHemoridHemorid CreamHemorid OintmentHemorrhoidal GRXHi-Tuss HCHistinex HCHistussin HCHistussin-HCHyco-DHHycomal DHHycomine CompoundHydro GPHydro-PC IIHydroFedHydron CPHydrophene DHHyphen-HDImmphentivIodal HDIsopto FrinK-TanKG-Dal HDLevall 5.0Liquicough HCLittle Noses DecongestantLortuss HCLusonalM-End PEM-PhenMax HCMaxi-Tuss HCMaxi-Tuss SAMaxiphen CDMaxiphen CDXMed-Hist-HCMedicone HemorrhoidalMintuss GMintuss HCMintuss MRMintuss MSMonteFlu HCMurocoll 2Myci SprayMydcombiMydfrinNalex-DHNariz HCNasatussNasopNasopen PENasotussNazarin HCNeo-SynephrineNotuss PDNotuss-PENovahistine DHOmidriaOtigesicPCMPancof-PDPediacofPeditussPhendal-HDPhenergan VCPhenergan VC with CodeinePhenyl-TPhenylephrine NasalPhenylephrine OphthalmicPhenylephrine, TopicalPhenylephrine-TropicamidePoly Hist DHCPoly Hist Forte (old formulation)Poly Hist PDPoly Hist PD (old formulation)Poly Tussin EXPoly-Tussin ACPoly-Tussin DHCPrefrinPrep-HemProhist CDProhist LQPyril DPyril Tann-12Pyrlex PDQ-Tuss with HydrocodoneQual-Tussin DCQuindal HDR(-)-PhenylephrineRectiCare Advance CreamRelacon-HCRelasin-HCRhinallRindal HPDRindal-HDRolatussRolatuss with HydrocodoneRu-Hist DRu-Hist-DRy-T-12Ryna-12S-T ForteSimuc-HDStatuss GreenSudafed PESudo-TabSudogest PET- KoffTL-Hist CDTannate 12D STannihist-12DTriant-HCTrimal DHTusana-DTusdec-HCTuss-DSTuss-HCTuss-PDTussafed-HCTusscough DHCTussi-12DTussi-12D STussinateTussirexTussive HCTussplexTympagesicUni Tuss HCUni-Lev 5.0Uni-Tricof HCVanacofVanacof APEVanex-HDVasosulfVazculepVazoTuss HCVazotabVentussVetuss HC SyrupViravan-SViravan-TWal-Dryl PEWal-Dryl-DWal-FourWal-Phed PEXyralidZ-Cof HCZincfrinZotex HCZotex-Cl-(3-Hydroxyphenyl)-N-methylethanolamineAntipyrine/Benzocaine/PhenylephrineBrompheniramine/Dihydrocodeine/PECarbetapentane/Diphenhydramine/PhenylephrineCarbetapentane/Guaifenesin/PhenylephrineChlorpheniramine/Dextromethorphan/PhenylephrineChlorpheniramine/GuaiFENesin/PhenylephrineChlorpheniramine/Hydrocodone/PhenylephrineChlorpheniramine/Phenylephrin/PhenyltoloxaminChlorpheniramine/Phenylephrine/PyrilamineDexbrompheniramine/Hydrocodone/PhenylephrineDexchlorpheniramine/Dextromethorphan/PhenylephrineDextromethorphan/Guaifenesin/PhenylephrineDextromethorphan/Phenylephrine/PyrilamineGuaifenesin/Hydrocodone/PhenylephrineGuaifenesin/PE/PPAPhenylephrine HClPhenylephrine HydrochloridePhenylephrinumR-Tannic-S A/D
RxNorm CUI
8163
ChEMBL ID
CHEMBL1215
ATC codes
R01AA04R01BA53R01BA03S01FB01S01GA05C01CA06S01GA55C05AX06R01AB01
UNII
1WS297W6MV

Clinical trials

151 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
151
registered trials across all phases
LATEST COMPLETION 2026
14
Active studies
13
Recruiting
122
Late-stage (III+)
98
Completed
39
Discontinued
PHASE DISTRIBUTIONn = 151
Early Phase 17Phase 17Phase 1 / 22Phase 213Phase 2 / 37Phase 311Phase 448Phase N / A56

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20132017
Major research themes2
Black People1White People1
Journals, researchers & institutions
Top journals
  • The pharmacogenomics journal2
  • Hypertension (Dallas, Tex. : 1979)1
Leading researchers
  • Adefurin A3
  • Ghimire LV3
  • Kohli U3
  • Kurnik D3
  • Muszkat M3
  • Paranjape SY3
  • Sofowora GG3
  • Stein CM3
Leading institutions
free-text, unnormalised
  • Division of Clinical Pharmacology3
  • Center for Human Genetics Research2
  • Clinical Pharmacology Unit1
  • Technion-Israel Institute of Technology1
  • Vanderbilt Genetics Institute1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials