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Drug

Poly I-C

In clinical development
Emerging researchEarly-to-mid developmentRising momentum
Also known as POLYINOSINIC-POLYCYTIDYLIC ACID (HIGH MW), POLYINOSINIC-POLYCYTIDYLIC ACID (LOW MW), Polyinosinic polycytidylic acid, Polyinosinic-polycytidylic acid+3 more

POLYINOSINIC-POLYCYTIDYLIC ACID (HIGH MW), POLYINOSINIC-POLYCYTIDYLIC ACID (LOW MW), Polyinosinic polycytidylic acid, Polyinosinic-polycytidylic acid, Polyinosinic-polycytidylic acid complex, Poly(I+C), PolyIC.

RxNorm2729810UNIIO84C90HH2L
3
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Poly I-C
Aliases & brands
POLYINOSINIC-POLYCYTIDYLIC ACID (HIGH MW)POLYINOSINIC-POLYCYTIDYLIC ACID (LOW MW)Polyinosinic polycytidylic acidPolyinosinic-polycytidylic acidPolyinosinic-polycytidylic acid complexPoly(I+C)PolyIC
RxNorm CUI
2729810
UNII
O84C90HH2L

Clinical trials

1 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
1
registered trials across all phases
1
Discontinued
PHASE DISTRIBUTIONn = 1
Phase 21

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20072024
Most influential

Maternal immune activation alters fetal brain development through interleukin-6.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007 · 1,270 cites

Trial watch: TLR3 agonists in cancer therapy.

Oncoimmunology · 2020 · 81 cites
Recent papers

Trial watch: TLR3 agonists in cancer therapy.

Oncoimmunology · 2020 · 81 cites

Maternal immune activation alters fetal brain development through interleukin-6.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007 · 1,270 cites
Major research themes5
Maternal-Fetal Relations1Mucopolysaccharidosis III1Neoplasms1Poly I-C1Toll-Like Receptor 31
Journals, researchers & institutions
Top journals
  • EMBO molecular medicine1
  • Oncoimmunology1
  • The Journal of neuroscience : the official journal of the Society for Neuroscience1
Leading researchers
  • Aguado È1
  • Bigger BW1
  • Boutin H1
  • Ellison S1
  • Forte G1
  • Galluzzi L1
  • Garbett K1
  • Holley RJ1
Leading institutions
free-text, unnormalised
  • California Institute of Technology1
  • Caryl and Israel Englander Institute for Precision Medicine1
  • Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 14281
  • Centre for Regenerative Medicine1
  • Geoffrey Jefferson Brain Research Centre1
  • Karolinska Institute1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials