Drug

Potassium

In clinical development

Emerging researchLate-stage developmentSteady momentum

Also known as K, Kalium, Neutra-Phos-K, Potasio+5 more

K, Kalium, Neutra-Phos-K, Potasio, K - Potassium, Potassium metal, Potassium, elemental, Potassium, metal, potassium(1+).

RxNorm8588 ChEMBLCHEMBL1201290UNIIRWP5GA015D

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Geospatial variability and nutrient partitioning of potassium, calcium, and magnesium in Iranian wheat grains: implications for flour and bread quality

Industry2026-07-10Nature — Environmental Sciences

Machine learning-based estimation and spatial mapping of soil phosphorus and potassium using sentinel-2 and environmental covariates

Industry2026-07-09Nature — Environmental Sciences

Machine learning reveals mechanisms and feedstock effects on potassium and magnesium uptake by wheat in biochar-amended soil in greenhouse

Industry2026-07-08Nature — Environmental Sciences

Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension

Clinical trial2026-04-06Results expected Q2 2027 · ClinicalTrials.gov

The TIGHT-K STUDY. Prevention of Dysrhythmias on the Cardiac Intensive Care Unit - Does Maintenance of High-normal Serum Potassium Levels Matter

Clinical trial2024-06-26Completed · ClinicalTrials.gov

Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.

Research2024-05-01Brain : a journal of neurology

Astroglial Kir4.1 potassium channel deficit drives neuronal hyperexcitability and behavioral defects in Fragile X syndrome mouse model.

Research2024-04-27Nature communications

Lifestyle factors, serum parameters, metabolic comorbidities, and the risk of kidney stones: a Mendelian randomization study.

Research2023-09-22Frontiers in endocrinology

ASPEN Consensus Recommendations for Refeeding Syndrome.

Research2020-03-02Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

The Physiology of the Gastric Parietal Cell.

Research2019-10-31Physiological reviews

PILOT STUDY for the Tight K TRIAL. Arrhythmias on the Cardiac Intensive Care Unit - Does Maintenance of High-normal Serum Potassium Levels Matter?

Clinical trial2018-05-29Completed · ClinicalTrials.gov

Study on the Effects of Sodium and Potassium on Blood Pressure, Vascular Function and Renal Function in Untreated (pre)hypertensive Subjects

Clinical trial2012-08-01Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Potassium

Aliases & brands

KKaliumNeutra-Phos-KPotasioK - PotassiumPotassium metalPotassium, elementalPotassium, metalpotassium(1+)

RxNorm CUI

8588

ChEMBL ID

CHEMBL1201290

UNII

RWP5GA015D

Clinical trials

7 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2024

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 7

Phase 12Phase 21Phase 32Phase 41Phase N / A1

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension

RecruitingPH IVBrigham and Women's Hospitaln=752027

The TIGHT-K STUDY. Prevention of Dysrhythmias on the Cardiac Intensive Care Unit - Does Maintenance of High-normal Serum Potassium Levels Matter

CompletedPH IIIKey trialBarts & The London NHS Trustn=1,6842024

PILOT STUDY for the Tight K TRIAL. Arrhythmias on the Cardiac Intensive Care Unit - Does Maintenance of High-normal Serum Potassium Levels Matter?

CompletedPH IIIBarts & The London NHS Trustn=1602018

Recent completions

Trials that read out recently, adding to the completed evidence base.

The TIGHT-K STUDY. Prevention of Dysrhythmias on the Cardiac Intensive Care Unit - Does Maintenance of High-normal Serum Potassium Levels Matter

CompletedPH IIIKey trialBarts & The London NHS Trustn=1,6842024

PILOT STUDY for the Tight K TRIAL. Arrhythmias on the Cardiac Intensive Care Unit - Does Maintenance of High-normal Serum Potassium Levels Matter?

CompletedPH IIIBarts & The London NHS Trustn=1602018

Study on the Effects of Sodium and Potassium on Blood Pressure, Vascular Function and Renal Function in Untreated (pre)hypertensive Subjects

CompletedN/AWageningen Universityn=402012

The Effects of Potassium on Physiological Variables in the Kidney and Cardiovascular Variables in Healthy Persons in a Double-blinded, Randomised, Placebo-controlled, Cross-over Study

CompletedPH IErling Bjerregaard Pedersenn=252011

Hypertension Prevention Trial (HPT) Feasibility Study

CompletedPH IINational Heart, Lung, and Blood Institute (NHLBI)1986

Research activity

6 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20172024

Most influential

ASPEN Consensus Recommendations for Refeeding Syndrome.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2020 · 245 cites

Gitelman syndrome: consensus and guidance from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney international · 2017 · 223 cites

The Physiology of the Gastric Parietal Cell.

Physiological reviews · 2020 · 177 cites

Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.

Brain : a journal of neurology · 2024 · 28 cites

Lifestyle factors, serum parameters, metabolic comorbidities, and the risk of kidney stones: a Mendelian randomization study.

Frontiers in endocrinology · 2023 · 27 cites

Astroglial Kir4.1 potassium channel deficit drives neuronal hyperexcitability and behavioral defects in Fragile X syndrome mouse model.

Nature communications · 2024 · 23 cites

Related diseases

1 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Active research areas

Disease Models, Animal2

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials